Naringinases: occurrence, characteristics, and applications

Ribeiro, Maria H.L.

doi:10.1007/s00253-011-3176-8

Cited by 100 publications

(85 citation statements)

References 64 publications

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“…This enzyme is also used for aroma enhancement in wine making and for preparation of many drugs as well as L-rhamnose. The latter plays the role of chiral intermediate in the organic synthesis of pharmaceutically important and plant protective agents [3][4][5][6][7].…”

Section: Discussionmentioning

confidence: 99%

“…The enzyme has wide occurrence in nature and has been reported from animals, plants, yeasts, fungi, and bacteria [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…1.40] are glycoside hydrolases, which catalyze the hydrolysis of terminal, non-reducing a-L-rhamnose residues in a-L-rhamnosides including glycolipids and glycosides, such as plant pigments, flavonoid glycosides, pectic polysaccharides, and gums [3][4][5][6][7]. The enzyme has wide occurrence in nature and has been reported from animals, plants, yeasts, fungi, and bacteria [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Lateral gene transfer between the Bacteroidetes and Acidobacteria: The case of α‐l‐rhamnosidases

Naumoff

Dedysh

2012

FEBS Letters

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a b s t r a c t a-L-Rhamnosidases catalyze the hydrolysis of the terminal a-L-rhamnose residues in various carbohydrates. The catalytic domains in most of these enzymes belong to the families GH78 and GH106 of glycoside hydrolases. In this study, we show that almost all genes encoding the GH78-and GH106-containing proteins from members of the poorly characterized bacterial phylum Acidobacteria originated from precursors belonging to the phylum Bacteroidetes. Members of the Acidobacteria and Bacteroidetes display similar functional capabilities and specialize on degradation of plant-derived organic matter. Several proposed lateral gene transfers between the Acidobacteria and Bacteroidetes occurred presumably during specialization of these bacteria for their environments.

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Section: Discussionmentioning

confidence: 99%

“…The enzyme has wide occurrence in nature and has been reported from animals, plants, yeasts, fungi, and bacteria [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lateral gene transfer between the Bacteroidetes and Acidobacteria: The case of α‐l‐rhamnosidases

Naumoff

Dedysh

2012

FEBS Letters

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“…3.2.1.21) activities. This hydrolytic enzymatic complex has wide occurrence in nature and has been reported in plants, yeasts, fungi, and bacteria [1]. The former enzyme splits naringin into rhamnose and prunin and the latter further hydrolyses prunin to D-glucose and naringenin, a nonbitter component, which cannot be converted back to naringin [2,3].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Process Parameters by Statistical Experimental Designs for the Production of Naringinase Enzyme by Marine Fungi

Shehata

Aty

2014

International Journal of Chemical Engineering

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Naringinase has attracted a great deal of attention in recent years due to its hydrolytic activities which include the production of rhamnose and prunin and debittering of citrus fruit juices. Screening of fifteen marine-derived fungi, locally isolated from Ismalia, Egypt, for naringinase enzyme production, indicated that Aspergillus niger was the most promising. In solid state fermentation (SSF) of the agroindustrial waste, orange rind was used as a substrate containing naringin. Sequential optimization strategy, based on statistical experimental designs, was employed to enhance the production of the debittering naringinase enzyme. Effects of 19 variables were examined for their significance on naringinase production using Plackett-Burman factorial design. Significant parameters were further investigated using Taguchi's (L16 4 5 ) orthogonal array design. Based on statistical analysis (ANOVA), the optimal combinations of the major constituents of media for maximal naringinase production were evaluated as follows: 15 g orange rind waste, 30 mL moisture content, 1% grape fruit, 1% NaNO 3 , 0.5% KH 2 PO 4 , 5 mM MgSO 4 , 5 mM FeSO 4 , and the initial pH 7.5. The activity obtained was more than 3.14-fold the basal production medium.

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“…All the bitter compound of flafelliferin (Fii) can be hydrolyzed by the glycolytic enzyme naringinase (Jansz et al, 2002 andJayaratnam 2015). The naringinase is a complex enzyme which has α-L-rhamnosidase and β-D-glucosidase activities that leads to potential usefulness in pharmaceuticals and food industries (Ribeiro 2011). In recent years, naringinase enzyme is widely used in debittering of palmyrah cordial, jams and citrus juice industries (Jansz et al, 2002 andKumar et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Characterization of best naringinase producing fungus strain isolated from palmyrah (Borrasus flabellifer) fruit pulp

Karuppaija¹,

Ranganathan²,

Seevaratnam³

2016

IJBR

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Background: The Palmyrah (Borrasus flabellifer L.) fruit pulp has the bitter compound flabelliferin (a tetraglycoside) which can be hydrolyzed by naringinase enzyme. The diverse groups of filamentous fungi and bacteria that live in different substrates have the capacity of producing extracellular naringinase enzyme which is of tremendous industrial value. Objective: The objective of the study was to isolate the naringinase producing fungal strains from Palmyrah and to identify the best naringinase producer under liquid and solid state fermentation systems. Methods: Fungal strains isolated from Palmyrah fruit pulp and the soil where pulp is allowed to decay, were grown on naringin agar selective medium at pH 6.0 at room temperature and the production of extracellular naringinase was measured in the liquid fermentation media and solid state fermentation system using paddy husk as support. Results: Five fungal strains isolated from the palmyrah pulp and the pulp decaying in sand designated as PF1,PF2,PF3,PF4 & PF5 had the ability to produce extracellular naringinase enzyme in liquid fermentation media. Fungal strain PF4 that showed highest naringinase enzyme activity (1.769U/ml) was selected among the isolated five fungal strains and identified as Rhizophus stolonifer based on the morphological and biochemical characteristics. When this strain was grown in the solid state fermentation system using paddy husk as media, narininase production was higher (269.84 U/gram of dry substrate) in seven days. Conclusion: Rhizophus stolonifer could be used to produce large scale naringinase enzyme under solid state fermentation system using very cheap, easily available, agricultural waste paddy husk as support without the need of expensive and well equipped laboratories.

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Naringinases: occurrence, characteristics, and applications

Cited by 100 publications

References 64 publications

Lateral gene transfer between the Bacteroidetes and Acidobacteria: The case of α‐l‐rhamnosidases

Lateral gene transfer between the Bacteroidetes and Acidobacteria: The case of α‐l‐rhamnosidases

Optimization of Process Parameters by Statistical Experimental Designs for the Production of Naringinase Enzyme by Marine Fungi

Characterization of best naringinase producing fungus strain isolated from palmyrah (Borrasus flabellifer) fruit pulp

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