Naringin Protects Pancreatic β‐Cells Against Oxidative Stress‐Induced Apoptosis by Inhibiting Both Intrinsic and Extrinsic Pathways in Insulin‐Deficient Diabetic Mice

Lim, Ye Jin; Kim, Jung Ho; Pan, Jeong Hoon; Kim, Jae Kyeom; Park, Tae‐Sik; Kim, Young Jun; Lee, Jin Hyup; Kim, Jun Ho

doi:10.1002/mnfr.201700810

Cited by 44 publications

(26 citation statements)

References 53 publications

(85 reference statements)

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“…Naringin, as reported by Sahnoun et al (2017), showed an excellent inhibition for α-amylase and α-glucosidase enzyme, with IC 50 values of 8.0 μM and 0.55 μM, respectively. Lim et al (2018) studied the protective effects and molecular mechanisms of naringin in diabetic mice. The results showed that this flavanone ameliorated hyperglycemia and protected STZ-induced β-cell death by inhibiting both intrinsic and extrinsic apoptotic pathways.…”

Section: Naringeninmentioning

confidence: 99%

Citrus species: Modern functional food and nutraceutical-based product ingredient

2021

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Citrus is the most cultivated fruit crop in the world and occupies a place of considerable importance in the country’s economy. Almost 33% of the citrus fruits are processed for juice production; however, a great amount of wastes, including peels, segment membranes, and seeds are also produced. Indeed, citrus fruits consist of 45% juice, 26% pulp, 27% peels, and 2% seeds. Pruning, a cultural practice involving the removal of tree branches and limbs, was applied to improve fruit’s quality. A large amount of leaves are produced through pruning. These agri-food matrices contain a wide range of bioactive phytochemicals compared to fruits. The present review covers the past 5 years of research carried out in chemistry, health properties, and applications in food and nutraceutical industries of all portions of citrus fruit and its major bioactive compounds. Additionally, patents are also included.

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Section: Naringeninmentioning

confidence: 99%

Citrus species: Modern functional food and nutraceutical-based product ingredient

2021

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“…Naringin also has a protective effect on β-cells due to its capacity to prevent apoptosis through the inhibition of both the intrinsic (mitochondria-mediated) and extrinsic (death receptor-mediated) pathways. These anti-apoptotic effects are associated with a reduction in ROS and inflammatory cytokines [63].…”

Section: Recent Preclinical Advances In the Anti-diabetic Actions Of mentioning

confidence: 99%

The Coming Age of Flavonoids in the Treatment of Diabetic Complications

Caro-Ordieres

Marín-Royo

Opazo-Ríos

et al. 2020

JCM

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Diabetes mellitus (DM), and its micro and macrovascular complications, is one of the biggest challenges for world public health. Despite overall improvement in prevention, diagnosis and treatment, its incidence is expected to continue increasing over the next years. Nowadays, finding therapies to prevent or retard the progression of diabetic complications remains an unmet need due to the complexity of mechanisms involved, which include inflammation, oxidative stress and angiogenesis, among others. Flavonoids are natural antioxidant compounds that have been shown to possess anti-diabetic properties. Moreover, increasing scientific evidence has demonstrated their potential anti-inflammatory and anti-oxidant effects. Consequently, the use of these compounds as anti-diabetic drugs has generated growing interest, as is reflected in the numerous in vitro and in vivo studies related to this field. Therefore, the aim of this review is to assess the recent pre-clinical and clinical research about the potential effect of flavonoids in the amelioration of diabetic complications. In brief, we provide updated information concerning the discrepancy between the numerous experimental studies supporting the efficacy of flavonoids on diabetic complications and the lack of appropriate and well-designed clinical trials. Due to the well-described beneficial effects on different mechanisms involved in diabetic complications, the excellent tolerability and low cost, future randomized controlled studies with compounds that have adequate bioavailability should be evaluated as add-on therapy on well-established anti-diabetic drugs.

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“…[10][11][12] Naringin regulates oxidative stress-induced apoptosis and the inflammatory response through intrinsic and extrinsic pathways, thereby effectively protecting pancreatic b-cells in insulin-deficient diabetic mice. 13 Naringin also ameliorates arsenicinduced cardiotoxicity, which is related to the Nrf2/HO-1 pathway. 14 Previously, we reported the effect of naringin on the inflammatory response of SIMD and its molecular mechanism.…”

Section: Introductionmentioning

confidence: 96%

Layer-specific strain for assessing the effect of naringin on systolic myocardial dysfunction induced by sepsis and its underlying mechanisms

Sun

Qiao

et al. 2021

J Int Med Res

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Objective This study aimed to investigate the protective effects of naringin on myocardial deformation and oxidative responses in rats with sepsis-induced myocardial dysfunction (SIMD). Methods Global and segmental layer-specific longitudinal strain (LS) was assessed by speckle tracking echocardiography. Serum levels of creatine kinase, lactate dehydrogenase, superoxide dismutase, and malondialdehyde were measured. The activity of cleaved caspase-3 was determined by immunohistochemistry. Protein expression levels of Kelch-like ECH-related protein 1 (Keap1), nuclear erythroid factor 2-related factor 2 (Nrf2), and heme oxygenase-1 (HO-1) were measured by western blotting. Results Naringin inhibited the lipopolysaccharide-induced decrease in global and layer-specific LS of the left ventricle. Naringin also increased superoxide dismutase expression and decreased malondialdehyde, creatine kinase, lactate dehydrogenase, and cleaved caspase-3 expression in rats with SIMD. Furthermore, naringin increased Nrf2 and HO-1 protein expression levels, and decreased Keap1 protein expression levels in rats with SIMD. Conclusion Layer-specific LS analysis of myocardial function by speckle tracking echocardiography can reflect early changes in myocardial systolic function. Naringin may possess a protective effect through moderating lipopolysaccharide-induced myocardial oxidative stress via the Keap1/Nrf2/HO-1 pathway in rats with SIMD.

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Naringin Protects Pancreatic β‐Cells Against Oxidative Stress‐Induced Apoptosis by Inhibiting Both Intrinsic and Extrinsic Pathways in Insulin‐Deficient Diabetic Mice

Abstract: Taken together, our study provides insights into the underlying mechanisms through which naringin protects the pancreatic β-cells against oxidative stress-induced apoptosis.

Cited by 44 publications

References 53 publications

Citrus species: Modern functional food and nutraceutical-based product ingredient

Citrus species: Modern functional food and nutraceutical-based product ingredient

The Coming Age of Flavonoids in the Treatment of Diabetic Complications

Layer-specific strain for assessing the effect of naringin on systolic myocardial dysfunction induced by sepsis and its underlying mechanisms

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