Naringin attenuates acute lung injury in LPS-treated mice by inhibiting NF-κB pathway

Liu, Ying; Wu, Hao; Nie, Yichu; Chen, Jialing; Sui, Weiwei; Li, Peibo

doi:10.1016/j.intimp.2011.05.022

Cited by 133 publications

(84 citation statements)

References 57 publications

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“…Besides kaempferol, myricetin and rutin, naringin also can inhibit the activation of iNOS enzyme and activation of NF-κB through barriers to degrades IκB and translocation of p65, a subunit of the protein NF-κB which undergo translocation into the cell nucleus when NF-κB regardless of IκB [24].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Mahkota Dewa (Phaleria Macrocarpa) (Scheff.) Fruit Pericarp Extract on Inos in Mice Colon Intermittently-Induced by Dextran Sodium Sulfate

Kusmardi

Shavera

Estuningtyas

et al. 2017

Asian J Pharm Clin Res

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Objective: The objective of this research was to investigate the anti-inflammatory effect of Mahkota Dewa fruit pericarp extract (Phaleria macrocarpa) on inducible nitric oxide synthase (iNOS) in mice colon induced by dextran sodium sulfate (DSS). Method:The simplisia of P. macrocarpa pericarp was weighed (1000 g) and extracted by maceration process. The total yield of the ethanolic extract was 26.43%. Phytochemical screening was carried out for the detection of the phytoconstituents by simple qualitative methods. The antiinflammatory activity was performed by DSS-induced colitis model through assessment of hematoxylin-eosin staining and expression of iNOS by immunohistochemistry assay at four different doses, i.e., 650, 1250, 2500, and 5000 mg/kg. Swiss Webster male mice weighing 25-30 g were used for the study.Results: Inflammation score in dose 625, 1250, 2500, and 5000 mg/kg were 1.63, 1.43, 1.32, and 2.20, respectively. This result is significantly different (p=0.008) with DSS group that was 4.37. The results of iNOS optical density score in dose 625, 1250, 2500, and 5000 mg/kg were 1.21, 1.119, 1.22, and 1.37, respectively. This result was significantly different (p=0.000) with DSS group that was 2.24. Conclusion:Pericarp extract of P. macrocarpa fruit exhibited anti-inflammatory activity in the experimental model shown by suppressing the expression of inflammatory cell and iNOS.

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Section: Discussionmentioning

confidence: 99%

The Effect of Mahkota Dewa (Phaleria Macrocarpa) (Scheff.) Fruit Pericarp Extract on Inos in Mice Colon Intermittently-Induced by Dextran Sodium Sulfate

Kusmardi

Shavera

Estuningtyas

et al. 2017

Asian J Pharm Clin Res

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“…24,25 The hydrolysis of naringin results into naringenin in the intestine and is catalyzed by enzymes including α-rhamnosidases and β-glucosidases. 26,27 Naringin interacts with the activities of transporters and enzymatic proteins in the intestine and hence, with the absorption and breakdown of certain drugs, results in altered blood levels. 28 Naringin has also been found to be antiviral, anti-cancer, hepatoprotective, cardioprotective and neuroprotective.…”

Section: Introductionmentioning

confidence: 99%

Treatment of Mice with Naringin Alleviates the Doxorubicin-Induced Oxidative Stress in the Liver of Swiss Albino Mice

Ch¹,

Jagetia²,

Lalrinengi³

2017

MOJAP

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Doxorubicin a photosensitive antibiotic is frequently used to treat various malignancies in clinics; however, doxorubicin is also taken up by the normal cells of the body leading to increased oxidative stress and subsequently DNA damage and dysfunction in the cells. The agents which can reduce the adverse effect of doxorubicin will of great value. The present study has attempted to study the effect of naringin a citrus flavonoid on the doxorubicininduced oxidative stress in mice liver. The mice were administered with 0, 1, 5 or 10mg/ kg body weight of doxorubicin and treated with 10mg/kg body weight of naringin before or after doxorubicin treatment. The glutathione concentration and lipid peroxidation and activities of glutathione-s-transferase, catalase and super oxide dismutase were studied at 0.5, 1, 2 and 4h post-treatment in the mouse liver. The doxorubicin increased the lipid peroxidation in a dose dependent manner at all the post treatment times. Conversely, it attenuated the activities of glutathione-s-transferase, catalase and super oxide dismutase in dose dependent fashion and time dependent manner. A similar effect was observed for glutathione concentration. Treatment of mice with naringin before or after doxorubicin treatment elevated all the antioxidants and reduced the doxorubicin -induced lipid peroxidation. The effect of naringin pretreatment was more effective when compared to its post treatment. The naringin was very effective in reducing the oxidative stress induced by doxorubicin as indicated by the elevated levels of glutathione concentration, glutathiones-transferase, catalase and super oxide dismutase. The pretreatment of naringin was better than its post treatment.

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“…Inducible nitric oxide synthase (iNOS) is the key enzyme involved in the NO production induced by proinflammatory cytokines, including interferon-gamma (INF-␥) and TNF-␣ (Moncada et al, 1991;Nathan and Xie, 1994). Increasing evidence suggests that inhibitors of iNOS may have the potential to treat clinical inflammatory disease (Liu et al, 2011). Among these pro-inflammatory cytokines, TNF-␣ seems to be particularly important for most of the symptoms of endotoxic shock (Jansen et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Isofraxidin protects mice from LPS challenge by inhibiting pro-inflammatory cytokines and alleviating histopathological changes

Liu

et al. 2015

Immunobiology

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Naringin attenuates acute lung injury in LPS-treated mice by inhibiting NF-κB pathway

Cited by 133 publications

References 57 publications

The Effect of Mahkota Dewa (Phaleria Macrocarpa) (Scheff.) Fruit Pericarp Extract on Inos in Mice Colon Intermittently-Induced by Dextran Sodium Sulfate

The Effect of Mahkota Dewa (Phaleria Macrocarpa) (Scheff.) Fruit Pericarp Extract on Inos in Mice Colon Intermittently-Induced by Dextran Sodium Sulfate

Treatment of Mice with Naringin Alleviates the Doxorubicin-Induced Oxidative Stress in the Liver of Swiss Albino Mice

Isofraxidin protects mice from LPS challenge by inhibiting pro-inflammatory cytokines and alleviating histopathological changes

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