Naringin Ameliorates Skeletal Muscle Atrophy and Improves Insulin Resistance in High-Fat-Diet-Induced Insulin Resistance in Obese Rats

Termkwancharoen, Chutimon; Malakul, Wachirawadee; Phetrungnapha, Amnat; Tunsophon, Sakara

doi:10.3390/nu14194120

Cited by 14 publications

(8 citation statements)

References 66 publications

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“…[37] Furthermore, Hao et al [38] found patients with concomitant exotropia exhibited statistically smaller medial rectus sizes by using high-resolution MRI. It is hypothesized that obesity-induced muscle atrophy [39][40][41][42][43] may be a contributing factor to the development of concomitant exotropia. At the molecular level, matrix metalloproteinases (MMPs) showed a positive correlation with the severity of intermittent exotropia, while tissue inhibitors of metalloproteinase (TIMPs) showed a negative correlation.…”

Section: Discussionmentioning

confidence: 99%

The causal effect of obesity on concomitant exotropia: A lifecourse Mendelian randomization study

Liu,

Zhao,

Liu

et al. 2024

Medicine

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Obesity is now a significant global public health issue. Limited understanding exists regarding the association between obesity and concomitant exotropia. Our objective was to identify the causal relationship between lifecourse obesity, including birth weight, childhood body mass index (BMI), and adult BMI, and the risk of concomitant exotropia. We used a two-sample Mendelian randomization (MR) strategy to examine the causal relationship with inverse-variance weighted method as the primary MR analysis. We carried out sensitivity analyses to evaluate the accuracy and robustness of our findings. Also, we performed reverse-direction MR analysis to eliminate the possibility of reverse causality. Childhood BMI, as opposed to birth weight or adult BMI, had a significant impact on the risk of concomitant exotropia (odds ratio = 1.40, 95% confidence interval (CI): 1.08–1.81, P = .01). This significance persisted even after accounting for birth weight and adult BMI using multivariable MR analysis (odds ratio = 1.35, 95% CI: 1.04–1.75, P = .02). There was no significant heterogeneity or pleiotropy observed in sensitivity analyses (P > .05). Multivariable MR analysis further confirmed the absence of pleiotropic effects of some risk factors including prematurity, maternal smoking around birth and refractive error. Reverse causality did not affect the causal relationship (beta = −0.0244, 95% CI: −0.0545 to 0.0056, P = .11). Genetic predisposition to higher childhood BMI was found to be causally linked to an increased risk of concomitant exotropia.

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Section: Discussionmentioning

confidence: 99%

The causal effect of obesity on concomitant exotropia: A lifecourse Mendelian randomization study

Liu,

Zhao,

Liu

et al. 2024

Medicine

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“…Naringin, a naturally occurring component in citrus fruits, alleviates insulin resistance and improves skeletal muscle atrophy. Termkwancharoen et al ( 17 ) revealed that in high-fat-diet-induced obese rats, naringin is an alternative supplement that improves the treatment of dyslipidaemia, decreases obesity-induced muscular dysfunction, and reduces insulin resistance while increasing sensitivity. Scutellarein, an active component in Erigeronbrevis-capus (Vant.…”

Section: The Mechanism Of Flavonoids On T2dmmentioning

confidence: 99%

Flavonoids improve type 2 diabetes mellitus and its complications: a review

Dong

Guo

et al. 2023

Front. Nutr.

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The prevalence of type 2 diabetes mellitus (T2DM) is increasing every year. Medications are currently the most common therapy for T2DM. However, these medications have certain adverse effects. In order to find safe and effective ways to improve this disease, researchers have discovered that some natural products can decrease blood sugar. Flavonoids are one of the most essential low molecular weight phenolic chemicals in the plant world, which widely exist in plant roots, stems, leaves, flowers, and fruits. They possess a variety of biological activities, including organ protection, hypoglycemic, lipid-lowering, anti-oxidative and anti-inflammatory effects. Some natural flavonoids ameliorate T2DM and its complications through anti-oxidation, anti-inflammatory action, glucose and lipid metabolism regulation, insulin resistance management, etc. Hence, this review aims at demonstrating the potential benefits of flavonoids in T2DM and its complications. This laid the foundation for the development of novel hypoglycemic medications from flavonoids.

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“…Simultaneously, it reduces α-GPDH enzyme activity, MyHC II expression, and the proportion of fast-twitch bers. Additionally, naringin boosts serum adiponectin levels, activating the expression of AdipoR1, APPL1, AMPK, and PGC-1α, thereby facilitating the transition of skeletal muscle bers from fast-twitch to slow-twitch states [35][36][37]. C2C12 cells are commonly used to study muscle development, muscle nutrient metabolism, and other muscle-related biological processes.…”

Section: Introductionmentioning

confidence: 99%

Naringin Ameliorates IL-6 Mediated mitochondrial dysfunction and skeletal muscle degeneratio via AMPK/Nrf-2 pathway

Gao,

Wang,

Zhang

et al. 2024

Preprint

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Ethnopharmacological relevance: Paraspinal muscle degeneration often arises as a hazardous consequence of intervertebral disc degeneration (IVDD). This degeneration correlates with oxidative stress and mitochondrial dysfunction. This study investigated the therapeutic potential of naringin in managing paraspinal muscle degeneration associated with disc degeneration. Materials and methods: C2C12 cells were stimulated with IL-6 to establish an in vitro model of skeletal muscle degeneration for assessing the protective impact of naringin on skeletal muscle. The most effective concentration of naringin in C2C12 cells was identified through a CCK8 assay. The antioxidant prowess of naringin was evaluated via biochemical methods and Elisa. The influences of naringin and IL-6 on apoptosis, mitochondrial function, and associated signaling pathways were examined using cytometry, ROS detection, western blot, and transmission electron microscopy. Results: Our findings demonstrated a significant reduction in discogenic paraspinal degeneration with naringin therapy. Naringin glycosides notably enhanced the expression of key proteins involved in both muscle anabolism and catabolism, including MAFbx, MuRF1, MyoD, and MyoG.Moreover, naringin contributed to maintaining redox homeostasis by augmenting antioxidant activity and preventing excessive ROS peroxide accumulation. To impede paraspinal muscle degeneration, naringin upregulated MyoD and MyoG expression while downregulating MAFbx and MuRF1 through the activation of AMPK/Nrf-2 signaling pathway. Conclusion: These findings underscore naringin's robust therapeutic potential in enhancing mitochondrial activity, regulating oxidative stress, and halting paraspinal muscle degeneration.

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Naringin Ameliorates Skeletal Muscle Atrophy and Improves Insulin Resistance in High-Fat-Diet-Induced Insulin Resistance in Obese Rats

Cited by 14 publications

References 66 publications

The causal effect of obesity on concomitant exotropia: A lifecourse Mendelian randomization study

The causal effect of obesity on concomitant exotropia: A lifecourse Mendelian randomization study

Flavonoids improve type 2 diabetes mellitus and its complications: a review

Naringin Ameliorates IL-6 Mediated mitochondrial dysfunction and skeletal muscle degeneratio via AMPK/Nrf-2 pathway

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