Naringenin suppresses neutrophil infiltration into adipose tissue in high-fat diet-induced obese mice

Tsuhako, Rika; Yoshida, Hiroki; Sugita, Chihiro; Kurokawa, Mineo

doi:10.1007/s11418-019-01332-5

Cited by 37 publications

(26 citation statements)

References 32 publications

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“… Preserved endothelium-dependent relaxation in the aortae ( Malakul et al, 2018 ). V. C57BL/6J Mice V. 100 mg/kg V. 14 days V. Naringenin V. Inhibited the infiltration of neutrophils in adipose tissues → reduced the expression of several chemokines MCP -1 and MCP-3, in the adipose tissues ( Tsuhako et al, 2020 ). VI.…”

Section: Discussionmentioning

confidence: 99%

A review of the lipolytic effects and the reduction of abdominal fat from bioactive compounds and moro orange extracts

Lima¹,

Barbosa²

2021

Heliyon

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Dietary supplementation containing Citrus sinensis extract is being widely used for weight loss due to its anti-adipogenic and antioxidant effects that regulate the metabolism of fatty acids. Bioactive compounds upregulate PPARα in the liver tissue, increasing oxidation of fatty acids and improving insulin sensitivity in addition to decreasing the expression of genes involved in the synthesis of fatty acids, such as LXRα and FAS. Studies on synephrine demonstrated their ability to stimulate the development of beige adipose tissue through greater expression of UCP1 and mtTFA, contributing to an increase in thermogenesis and mitochondrial biogenesis. However, despite its widespread use to reduce abdominal fat, few scientific studies have consensually proven the effectiveness of Moro orange extract for weight loss. This literature review summarizes the current information on the pharmacological and molecular mechanisms involved in the modulation of lipid metabolism by the bioactive compounds present in Moro orange extract.

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Section: Discussionmentioning

confidence: 99%

A review of the lipolytic effects and the reduction of abdominal fat from bioactive compounds and moro orange extracts

Lima¹,

Barbosa²

2021

Heliyon

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“…Additionally, in our previous studies, we have shown that the citrus flavonoid, naringenin (100 mg/kg/d), dissolved in methylcellulose reduced macrophage and neutrophil infiltration into the adipose tissue of mice. 17,18) Therefore, we chose to use 0.063 and 0.125% (w/v) GH. This is because when the mouse weight is 20 and 40 g, respectively, the GH dose will be about 100 mg/kg/d.…”

Section: Methodsmentioning

confidence: 99%

“…The SVF was prepared from adipose tissue as previously described. 17,19) Briefly, epididymal fat pads were cut into small pieces and rinsed in an N-(2-hydroxyethyl) piperazine-N′-2-ethanesulfonic acid-based Ringer's solution. The fat pieces were then incubated at 37 °C for 30 min in a collagenase type 1 solution.…”

Section: Preparation Of the Stromal Vascular Fraction (Svf) Of Adiposmentioning

confidence: 99%

Glucosyl Hesperidin Has an Anti-diabetic Effect in High-Fat Diet-Induced Obese Mice

Yoshida

Tsuhako

Sugita

et al. 2021

Biological & Pharmaceutical Bulletin

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Glucosyl hesperidin (GH) is a water-soluble derivative of hesperidin, a citrus flavonoid. GH has various pharmacological effects, such as hypolipidemic and hypouricemic effects, and may therefore be a useful supplement or drug. In the present study, we evaluated the effects of long-and short-term intake of GH on hyperglycemia and macrophage infiltration into the adipose tissue of high-fat diet (HFD)-fed mice. Longterm (11-week) consumption of GH tended to reduce body weight and the fasting blood glucose concentration of the HFD-fed mice, and ameliorated glucose intolerance and insulin resistance, according to glucose and insulin tolerance tests. Additionally, although GH did not affect fat pad weight, it reduced HFD-induced macrophage infiltration into adipose tissue. Short-term (2-week) consumption of GH did not affect the HFDinduced increases in body weight or fasting blood glucose, and it did not ameliorate glucose intolerance or insulin resistance. However, short-term intake did reduce the HFD-induced macrophage infiltration and monocyte chemotactic protein 1 (MCP-1) expression in adipose tissue. Furthermore, hesperetin, which is an aglycone of GH, inhibited MCP-1 expression in 3T3-L1 adipocytes, 3T3-L1 adipocytes co-cultured with RAW264 macrophages, and tumor necrosis factor-α-treated 3T3-L1 adipocytes. The present findings suggest that daily consumption of GH may have preventive and/or therapeutic effects on obesity-related diseases, such as diabetes mellitus.

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“…In a short-term HFD mice model, naringenin can suppress neutrophil and macrophage infiltration into adipose tissue [ 215 ]. Concretely it can inhibit the expression of several chemokines like MCP-1 and MCP-3 [ 217 ]. Eriodyctiol (ED) supplementation on its side lowered the adiposity in diet-induced obese mice by regulating gene expression.…”

Section: Flavanonesmentioning

confidence: 99%

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

et al. 2020

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The prevention and treatment of obesity is primary based on the follow-up of a healthy lifestyle, which includes a healthy diet with an important presence of bioactive compounds such as polyphenols. For many years, the health benefits of polyphenols have been attributed to their anti-oxidant capacity as free radical scavengers. More recently it has been described that polyphenols activate other cell-signaling pathways that are not related to ROS production but rather involved in metabolic regulation. In this review, we have summarized the current knowledge in this field by focusing on the metabolic effects of flavonoids. Flavonoids are widely distributed in the plant kingdom where they are used for growing and defensing. They are structurally characterized by two benzene rings and a heterocyclic pyrone ring and based on the oxidation and saturation status of the heterocyclic ring flavonoids are grouped in seven different subclasses. The present work is focused on describing the molecular mechanisms underlying the metabolic impact of flavonoids in obesity and obesity-related diseases. We described the effects of each group of flavonoids in liver, white and brown adipose tissue and central nervous system and the metabolic and signaling pathways involved on them.

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Naringenin suppresses neutrophil infiltration into adipose tissue in high-fat diet-induced obese mice

Cited by 37 publications

References 32 publications

A review of the lipolytic effects and the reduction of abdominal fat from bioactive compounds and moro orange extracts

A review of the lipolytic effects and the reduction of abdominal fat from bioactive compounds and moro orange extracts

Glucosyl Hesperidin Has an Anti-diabetic Effect in High-Fat Diet-Induced Obese Mice

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

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