Naringenin modulates the metastasis of human prostate cancer cells by down regulating the matrix metalloproteinases -2/-9 via ROS/ERK1/2 pathways

Lin, Er Jiang; Zhang, Xian; Wang, Da Ya; Hong, Shi; Li, Lei Yu

doi:10.3329/bjp.v9i3.19730

Cited by 8 publications

(4 citation statements)

References 49 publications

(34 reference statements)

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“…Naringenin has been reported to have a protective effect on carbon tetracholride induced acute nephrotoxicity in mouse models 42 . Naringenin is reported to be an effective chemotherapeutic agent for prostate cancer 43 . It has also been reported that S. trilobatum possesses neuroprotective role against pathology of Parkinson’s disease 44 .…”

Section: Resultsmentioning

confidence: 99%

RNA sequencing and de novo assembly of Solanum trilobatum leaf transcriptome to identify putative transcripts for major metabolic pathways

Lateef

Prabhudas

Natarajan

2018

Sci Rep

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Solanum trilobatum L. is an important medicinal plant in traditional Indian system of medicine belonging to Solanaceae family. However, non-availability of genomic resources hinders its research at the molecular level. We have analyzed the S. trilobatum leaf transcriptome using high throughput RNA sequencing. The de novo assembly of 136,220,612 reads produced 128,934 non-redundant unigenes with N50 value of 1347 bp. Annotation of unigenes was performed against databases such as NCBI nr database, Gene Ontology, KEGG, Uniprot, Pfam, and plnTFDB. A total of 60,097 unigenes were annotated including 48 Transcription Factor families and 14,490 unigenes were assigned to 138 pathways using KEGG database. The pathway analysis revealed the transcripts involved in the biosynthesis of important secondary metabolites contributing for its medicinal value such as Flavonoids. Further, the transcripts were quantified using RSEM to identify the highly regulated genes for secondary metabolism. Reverse-Transcription PCR was performed to validate the de novo assembled unigenes. The expression profile of selected unigenes from flavonoid biosynthesis pathway was analyzed using qRT-PCR. We have also identified 13,262 Simple Sequence Repeats, which could help in molecular breeding. This is the first report of comprehensive transcriptome analysis in S. trilobatum and this will be an invaluable resource to understand the molecular basis related to the medicinal attributes of S. trilobatum in further studies.

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Section: Resultsmentioning

confidence: 99%

RNA sequencing and de novo assembly of Solanum trilobatum leaf transcriptome to identify putative transcripts for major metabolic pathways

Lateef

Prabhudas

Natarajan

2018

Sci Rep

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“…In its structure, naringenin has two hydroxyl groups in the sites 5 and 7 of the A ring, and a carbonyl group in the site 4 of C ring that reduce iron ions and avoid oxidative reactions (Cook & Samman, 1996). Naringenin is abundant in foods such as citric fruits, honey, bee pollen (Zheng et al, 2019), besides having antioxidant activity (Cavia-Saiz et al, 2010), it has been reported to have immunomodulatory activity (Maatouk et al, 2016) as well as antitumoral (Lin et al, 2014), anti-inflammatory (Li et al, 2015), antiaterogenic (Lee et al, 2001), and UVB-radiation protector activities (El-Mahdy et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Valorization of Campomanesia xanthocarpaleaves: Chemical composition and antioxidant activity of crude extract and fractions

Sugauara¹,

Bortolucci²,

Fernandez³

et al. 2023

BLACPMA

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Campomanesia xanthocarpaleaves are a byproduct of fruit production without studies on antioxidant activity. Thus, this study aimed to identify the antioxidant compounds of C. xanthocarpaleaves by ultra-high performance liquid chromatography coupled with electrospray ionization-quadrupole-time of flight-mass spectrometry (UHPLC-ESI/qTOF) and by different in vitroantioxidant methods. The crude extract of C. xanthocarpaleaves had a yield of 15.2% and only five out of 37 fractions of the crude extract had antioxidant activity. The crude extract presented greater antioxidant activity than the isolated fractions. The identified antioxidant compounds were phenolic acids (gallic acid and chlorogenic acid), flavonoids (quercetin and naringenin 7,4’-dimethoxy) and an organic acid (quinic acid). Leaves of C. xanthocarpahave high concentration of antioxidant compounds and it is a promising plant for the development of applications in the food, cosmetic, and pharmaceutical fields. The extraction of antioxidant compounds can add value to the productive chain of this plant.

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“…Various pharmacological activities of NG, including antibacterial (Ng'uni et al 2015), antiviral (Lulu et al 2015;Meng et al 2015), antidiabetic (Bhattacharya et al 2014;Priscilla et al 2014), cardioprotective (Kara et al 2014), neuroprotective (Raza et al 2013), and nephroprotective effects (Hermenean et al 2013), were described. Previous studies have also reported that naringenin has antioxidative (Cavia-Saiz et al 2010;Kneževiae and Petlevski 2014), anti-inflammatory Wu et al 2015), and anticancer (Lin et al 2014) activities. The aim of this study was to investigate and to compare the immunomodulatory activity and cellular antioxidant potential of native naringenin (NG) and heated naringenin (hNG).…”

Section: Introductionmentioning

confidence: 89%

Effect of heated naringenin on immunomodulatory properties and cellular antioxidant activity

Maâtouk

Elgueder

Mustapha

et al. 2016

Cell Stress and Chaperones

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Naringenin is one of the most popular flavonoids derived from citrus. It has been reported to be an effective antiinflammatory compound. Citrus fruit may be used raw, cooked, stewed, or boiled. The present study was conducted to investigate the effect of thermal processes on naringenin in its immunomodulatory and cellular antioxidant activities. The effects of flavonoids on B and T cell proliferation were assessed on splenocytes stimulated or not with mitogens. However, their effects on cytotoxic T lymphocyte (CTL) and natural killer (NK) activities were assessed in splenocytes co-incubated with target cells. The amount of nitric oxide production and the lysosomal enzyme activity were evaluated in vitro on mouse peritoneal macrophages. Cellular antioxidant activity in splenocytes and macrophages was determined by measuring the fluorescence of the dichlorofluorescin (DCF). Our findings revealed that naringenin induces B cell proliferation and enhances NK activity. The highest concentration of native naringenin exhibits a significant proliferation of T cells, induces CTL activity, and inhibits cellular oxidation in macrophages. Conversely, it was observed that when heatprocessed, naringenin improves the cellular antioxidant activity in splenocytes, increases the cytotoxic activity of NK cells, and suppresses the cytotoxicity of T cells. However, heat treatment maintains the anti-inflammatory potency of naringenin.

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Naringenin modulates the metastasis of human prostate cancer cells by down regulating the matrix metalloproteinases -2/-9 via ROS/ERK1/2 pathways

Cited by 8 publications

References 49 publications

RNA sequencing and de novo assembly of Solanum trilobatum leaf transcriptome to identify putative transcripts for major metabolic pathways

RNA sequencing and de novo assembly of Solanum trilobatum leaf transcriptome to identify putative transcripts for major metabolic pathways

Valorization of Campomanesia xanthocarpaleaves: Chemical composition and antioxidant activity of crude extract and fractions

Effect of heated naringenin on immunomodulatory properties and cellular antioxidant activity

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