Naringenin inhibits α-glucosidase activity: A promising strategy for the regulation of postprandial hyperglycemia in high fat diet fed streptozotocin induced diabetic rats

Priscilla, David Hansi; Roy, Debasish; Suresh, Aishwarya; Kumar, Vinod; Thirumurugan, Kavitha

doi:10.1016/j.cbi.2013.12.014

Cited by 135 publications

(74 citation statements)

References 37 publications

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“…Naringenin showed a strong a-glucosidase inhibitory activity in a competitive manner with inhibition constant of 3.17 Â 10 À4 mol L À1 (Priscilla, Roy, Suresh, Kumar, & Thirumurugan, 2014). Kaempferol (structure shown in Fig.…”

Section: Introductionmentioning

confidence: 98%

Inhibitory kinetics and mechanism of kaempferol on α-glucosidase

et al. 2016

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Section: Introductionmentioning

confidence: 98%

Inhibitory kinetics and mechanism of kaempferol on α-glucosidase

et al. 2016

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“…Since ThT-treated animals showed lower levels of serum alpha-amylase, and a slight in vitro inhibitory effect had also been observed for ThT toward alpha-amylase enzyme (10), the current findings on blood glucose levels and weight may be partly attributed to this property of ThT. In fact, glucosidase inhibitors may be beneficial in the "diabesity" state, by lowering postprandial glucose levels (18,19) and helping in weight loss (20,21). Alphaamylase inhibitors have been observed to positively affect disturbed lipid profiles too (22).…”

Section: Hepatocytesmentioning

confidence: 74%

Benzothiazole Thioflavin T improves obesity-related symptoms in mice

et al. 2016

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“…[174][175][176][177][178][179][180] Due to their higher potential activity in many chronic diseases, they are widely used to prepare novel beverages. However, due to the limited oral bioavailability and stability of those compounds, alternative nano-based delivery technologies have been recently studied to assess their efficacy.…”

Section: Nano-naringeninmentioning

confidence: 99%

Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status

Ganesan¹,

Arulselvan²,

Choi³

2017

IJN

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Type 2 diabetes mellitus (T2DM) is a major chronic disease that is prevalent worldwide, and it is characterized by an increase in blood glucose, disturbances in the metabolism, and alteration in insulin secretion. Nowadays, food-based therapy has become an important treatment mode for type 2 diabetes, and phytobioactive compounds have gained an increasing amount of attention to this end because they have an effect on multiple biological functions, including the sustained secretion of insulin and regeneration of pancreatic islets cells. However, the poor solubility and lower permeability of these phyto products results in a loss of bioactivity during processing and oral delivery, leading to a significant reduction in the bioavailability of phytobioactive compounds to treat T2DM. Recently, nanotechnological systems have been developed for use as various types of carrier systems to improve the delivery of bioactive compounds and thus obtain a greater bioavailability. Furthermore, carrier systems in most nanodelivery systems are highly biocompatible, with nonimmunologic behavior, a high degree of biodegradability, and greater mucoadhesive strength. Therefore, this review focuses on the various types of nanodelivery systems that can be used for phytobioactive compounds in treating T2DM with greater antidiabetic effects. There is also additional focus on improving the effects of various phytobioactive compounds through nanotechnological delivery to ensure a highly efficient treatment of type 2 diabetes.

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Naringenin inhibits α-glucosidase activity: A promising strategy for the regulation of postprandial hyperglycemia in high fat diet fed streptozotocin induced diabetic rats

Cited by 135 publications

References 37 publications

Inhibitory kinetics and mechanism of kaempferol on α-glucosidase

Inhibitory kinetics and mechanism of kaempferol on α-glucosidase

Benzothiazole Thioflavin T improves obesity-related symptoms in mice

Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status

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Naringenin inhibits α-glucosidase activity: A promising strategy for the regulation of postprandial hyperglycemia in high fat diet fed streptozotocin induced diabetic rats

Cited by 135 publications

References 37 publications

Inhibitory kinetics and mechanism of kaempferol on α-glucosidase

Inhibitory kinetics and mechanism of kaempferol on α-glucosidase

Benzothiazole Thioflavin T improves obesity-related symptoms in mice

Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus &ndash; current status

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Product

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Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status