Naringenin improves depressive- and anxiety-like behaviors in mice exposed to repeated hypoxic stress through modulation of oxido-inflammatory mediators and NF-kB/BDNF expressions

Olugbemide, Abimbola S.; Ben‐Azu, Benneth; Bakre, Adewale G.; Ajayi, Abayomi Mayowa; Femi-Akinlosotu, Omowumi; Umukoro, Solomon

doi:10.1016/j.brainresbull.2020.12.003

Cited by 56 publications

(32 citation statements)

References 70 publications

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“…Naringin was better at binding to and inhibiting the formation of toxic SOD1 aggregates than naringenin. Naringenin also showed beneficial effects in ameliorating depressive and anxiety-like behaviors in hypoxic stressed animals [481]. It acted on oxidative stress, pro-inflammatory cytokine production and NF-kB/BDNF expression.…”

Section: Citrus Sppmentioning

confidence: 95%

Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis

Walczak-Nowicka

Herbet

2021

IJMS

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Acetylcholinesterase (AChE) plays an important role in the pathogenesis of neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative stress and aggregation of pathological proteins. There is a search for new compounds that can prevent the occurrence of neurodegenerative diseases and slow down their course. The aim of this review is to present the role of AChE in the pathomechanism of neurodegenerative diseases. In addition, this review aims to reveal the benefits of using AChE inhibitors to treat these diseases. The selected new AChE inhibitors were also assessed in terms of their potential use in the described disease entities. Designing and searching for new drugs targeting AChE may in the future allow the discovery of therapies that will be effective in the treatment of neurodegenerative diseases.

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Section: Citrus Sppmentioning

confidence: 95%

Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis

Walczak-Nowicka

Herbet

2021

IJMS

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“…The major compound detected on the GC-MS was naringenin, a flavanone, which has received considerable attention regarding its pharmacodynamic activities [39,40]. These include: antioxidant activity, through the increase of antioxidant enzymes [41]; anti-inflammatory activity [42]; anticancer activity, namely by the suppressive effect on TGF-β signaling pathway, and so cytotoxic effect in many cell lines, such as colon, pancreas, leukemia, stomach, liver and breast [43,44]; anti-diabetic activity [45]; and effects on central nervous system and on cardiovascular system [46][47][48][49][50]. According to the literature, naringenin is a flavonoid compound present in elderflower extracts.…”

Section: Chemical Composition Of S Nigra Extractmentioning

confidence: 99%

Chemical Characterization of Sambucus nigra L. Flowers Aqueous Extract and Its Biological Implications

et al. 2021

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The main goal of this study was to chemically characterize an aqueous S. nigra flower extract and validate it as a bioactive agent. The elderflower aqueous extraction was performed at different temperatures (50, 70 and 90 °C). The extract obtained at 90 °C exhibited the highest phenolic content and antiradical activity. Therefore, this extract was analyzed by GC-MS and HPLC-MS, which allowed the identification of 46 compounds, being quercetin and chlorogenic acid derivatives representative of 86% of the total of phenolic compounds identified in hydrophilic fraction of the aqueous extract. Naringenin (27.2%) was the major compound present in the lipophilic fraction. The antiproliferative effects of the S. nigra extract were evaluated using the colon cancer cell lines RKO, HCT-116, Caco-2 and the extract’s antigenotoxic potential was evaluated by the Comet assay in RKO cells. The RKO cells were the most susceptible to S. nigra flower extract (IC50 = 1250 µg mL−1). Moreover, the extract showed antimicrobial activity against Gram-positive bacteria, particularly Staphylococcus aureus and S. epidermidis. These results show that S. nigra-based extracts can be an important dietary source of bioactive phenolic compounds that contribute to health-span improving life quality, demonstrating their potential as nutraceutical, functional foods and/or cosmetic components for therapeutic purposes.

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“…Liquiritin, naringenin, diosgenin, and quercetin are potential active components in SZRT and mapped to anxiety-related targets of SOD1. Liquiritin, naringenin, and quercetin are flavonoid antioxidant and diosgenin isolated from ZM, which all have a remarkable antioxidant effect [32][33][34] and enhanced SOD activity in many animal models. It had also been reported that quercetin and naringenin also alleviate anxiety-like behaviors and regulated oxidative signs [35,36].…”

Section: Discussionmentioning

confidence: 99%

Study on the Antianxiety Mechanism of Suanzaoren Decoction Based on Network Pharmacology and Molecular Docking

Gao

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objective. Suanzaoren Decoction (SZRT) is a classic decoction to calm the nerves in traditional Chinese medicine (TCM). It has been extensively treated as an antianxiety drug in modern times, but the material basis and pharmacological mechanisms are still unclear. To explore the material basis and corresponding potential targets, as well as to elucidate the mechanism of SZRT, network pharmacology and molecular docking methods were utilized. Methods. The main chemical compounds and potential targets of SZRT were collected from the pharmacological database analysis platform (TCMSP). Anxiety targets were obtained from the GeneCards database. Then, a target compound network was established using overlapping genes and the corresponding potential compounds. Protein interaction analysis, GO enrichment, and KEGG pathway enrichment were performed using the STRING database, DAVID database, and KOBAS database. Finally, molecular docking was conducted between MAOB and its corresponding active compound in SZRT to further verify the results. Results. A total of 137 active components in SZRT were screened from the TCMSP database, and 210 corresponding targets were predicted. A total of 5434 anxiety-related targets were obtained from the disease target database, and finally 22 potential targets of SZRT on antianxiety were obtained. The constructed C-T network showed that the average degree of active components was 5.4, and four of them interacted with six or more targets. PPI analysis shows that key genes such as MAOA, MAOB, IL1B, TNF, NR3CI, and HTR3A were identified as potential therapeutic targets. A pathway analysis showed that SZRT may participate in neurotransmitter regulation and immunoregulation in a synergistic way to treat anxiety. The binding energy between the active compounds and MAOB was low, indicating good binding. The results of molecular docking showed that all the 10 active ingredients were able to successfully dock with MAOB, and the binding energy of coumaroyltyramine with MAOB was the lowest, that is, −9.6 kcal/mol, and the binding method was hydrogen bonding. Conclusions. SZRT produces antianxiety effects mainly by affecting the neurotransmitter release, transmission, and immunoregulation. This study provides a new approach to elucidating the molecular mechanism and material basis of SZRT in the treatment of anxiety, and it will also benefit the application of TCM in modern medicine.

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Naringenin improves depressive- and anxiety-like behaviors in mice exposed to repeated hypoxic stress through modulation of oxido-inflammatory mediators and NF-kB/BDNF expressions

Cited by 56 publications

References 70 publications

Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis

Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis

Chemical Characterization of Sambucus nigra L. Flowers Aqueous Extract and Its Biological Implications

Study on the Antianxiety Mechanism of Suanzaoren Decoction Based on Network Pharmacology and Molecular Docking

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