Naringenin confers protection against experimental autoimmune encephalomyelitis through modulating the gut-brain axis: A multiomics analysis

Liu, Zejin; Sun, Mengyang; Jin, Chaolei; Sun, Xiaoying; Feng, Fangyu; Niu, Xinli; Wang, Bin; Zhang, Yijie; Wang, Junpeng

doi:10.1016/j.jnutbio.2023.109448

Cited by 1 publication

(1 citation statement)

References 79 publications

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“…Zarzissine is an alkaloid that has hypoglycemic and anti-inflammatory effects [71]. The biological activity of hispidulin, luteolin-3 ′ -O-glucoside, and naringenin has also been widely reported, and these components have anti-inflammatory, antioxidant, antifungal, anti-cancer, and neuroprotective properties, as well as immunoregulatory activity [28,72,73]. Jujubogenin has been found in the leaves of yellowhorn, which has notable neuroprotective effects in dementia-related diseases, such as Alzheimer's disease, via its anti-inflammation, anti-apoptosis, and antioxidant properties [74].…”

Section: Network Pharmacology Of the Leaf And Flower Of Yellowhornmentioning

confidence: 99%

Widely Targeted Metabolomics and Network Pharmacology Reveal the Nutritional Potential of Yellowhorn (Xanthoceras sorbifolium Bunge) Leaves and Flowers

Sha,

Li,

et al. 2024

Foods

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Yellowhorn (Xanthoceras sorbifolium Bunge) is a unique oilseed tree in China with high edible and medicinal value. However, the application potential of yellowhorn has not been adequately explored. In this study, widely targeted metabolomics (HPLC-MS/MS and GC-MS) and network pharmacology were applied to investigate the nutritional potential of yellowhorn leaves and flowers. The widely targeted metabolomics results suggested that the yellowhorn leaf contains 948 non-volatile metabolites and 638 volatile metabolites, while the yellowhorn flower contains 976 and 636, respectively. A non-volatile metabolite analysis revealed that yellowhorn leaves and flowers contain a variety of functional components beneficial to the human body, such as terpenoids, flavonoids, alkaloids, lignans and coumarins, phenolic acids, amino acids, and nucleotides. An analysis of volatile metabolites indicated that the combined action of various volatile compounds, such as 2-furanmethanol, β-icon, and 2-methyl-3-furanthiol, provides the special flavor of yellowhorn leaves and flowers. A network pharmacology analysis showed that various components in the flowers and leaves of yellowhorn have a wide range of biological activities. This study deepens our understanding of the non-volatile and volatile metabolites in yellowhorn and provides a theoretical basis and data support for the whole resource application of yellowhorn.

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Section: Network Pharmacology Of the Leaf And Flower Of Yellowhornmentioning

confidence: 99%

Widely Targeted Metabolomics and Network Pharmacology Reveal the Nutritional Potential of Yellowhorn (Xanthoceras sorbifolium Bunge) Leaves and Flowers

Sha,

Li,

et al. 2024

Foods

View full text Add to dashboard Cite

show abstract

Naringenin confers protection against experimental autoimmune encephalomyelitis through modulating the gut-brain axis: A multiomics analysis

Cited by 1 publication

References 79 publications

Widely Targeted Metabolomics and Network Pharmacology Reveal the Nutritional Potential of Yellowhorn (Xanthoceras sorbifolium Bunge) Leaves and Flowers

Widely Targeted Metabolomics and Network Pharmacology Reveal the Nutritional Potential of Yellowhorn (Xanthoceras sorbifolium Bunge) Leaves and Flowers

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