Naringenin: an analgesic and anti-inflammatory citrus flavanone

Manchope, Marília F.; Casagrande, Rúbia; Verri, Waldiceu A.

doi:10.18632/oncotarget.14084

Cited by 71 publications

(33 citation statements)

References 8 publications

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“…Like the previous subgroup, flavanones also influence and interact with GM [ 28 , 77 , 78 ]. The main compounds included here also exhibit anti-inflammatory properties, such as hesperetin [ 79 , 80 ], naringenin [ 81 ], morin [ 82 – 84 ], and eriodictyol [ 85 – 87 ]. Additionally, they influence lipid metabolism as a potential preventive strategy for obesity.…”

Section: Experimental Nutritional Interventions With Phytochemicalmentioning

confidence: 99%

Phytochemicals That Influence Gut Microbiota as Prophylactics and for the Treatment of Obesity and Inflammatory Diseases

Carrera-Quintanar

López-Roa

Quintero-Fabián

et al. 2018

Mediators of Inflammation

142

118

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Gut microbiota (GM) plays several crucial roles in host physiology and influences several relevant functions. In more than one respect, it can be said that you “feed your microbiota and are fed by it.” GM diversity is affected by diet and influences metabolic and immune functions of the host's physiology. Consequently, an imbalance of GM, or dysbiosis, may be the cause or at least may lead to the progression of various pathologies such as infectious diseases, gastrointestinal cancers, inflammatory bowel disease, and even obesity and diabetes. Therefore, GM is an appropriate target for nutritional interventions to improve health. For this reason, phytochemicals that can influence GM have recently been studied as adjuvants for the treatment of obesity and inflammatory diseases. Phytochemicals include prebiotics and probiotics, as well as several chemical compounds such as polyphenols and derivatives, carotenoids, and thiosulfates. The largest group of these comprises polyphenols, which can be subclassified into four main groups: flavonoids (including eight subgroups), phenolic acids (such as curcumin), stilbenoids (such as resveratrol), and lignans. Consequently, in this review, we will present, organize, and discuss the most recent evidence indicating a relationship between the effects of different phytochemicals on GM that affect obesity and/or inflammation, focusing on the effect of approximately 40 different phytochemical compounds that have been chemically identified and that constitute some natural reservoir, such as potential prophylactics, as candidates for the treatment of obesity and inflammatory diseases.

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Section: Experimental Nutritional Interventions With Phytochemicalmentioning

confidence: 99%

Phytochemicals That Influence Gut Microbiota as Prophylactics and for the Treatment of Obesity and Inflammatory Diseases

Carrera-Quintanar

López-Roa

Quintero-Fabián

et al. 2018

Mediators of Inflammation

142

118

View full text Add to dashboard Cite

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“…Through ADME screening, 44 out of 150 components were selected from Zhishi, and most of them have ideal pharmacokinetic profiles. For example, hesperetin (ZS108, OB = 47.74%, Caco-2 = 0.28, DL = 0.27, GI = high) exhibits antioxidants (de Souza et al, 2016 ), anti-inflammatory(Choi and Lee, 2010 ), and vasoprotective (Kumar et al, 2013 ) actions; Similarly, naringenin (ZS115, OB = 59.29%, Caco-2 = 0.28, DL = 0.21, GI = high) has anti-inflammatory (Manchope et al, 2017 ), antibacterial (Wang L. H. et al, 2017 ), neuroprotective(Ramakrishnan et al, 2016 ) effects. It is worth noting that the value of Caco-2 in dihydroflavonosides of Zhishi is lower, such as narirutin (ZS144), naringin (ZS143), hesperidin (ZS130), and neohesperidin (ZS150), however, the four flavonoids were the main bioactive components in Zhishi and exhibited relatively high abundances (Liu et al, 2012 ), so these components were also preserved.…”

Section: Resultsmentioning

confidence: 99%

System Pharmacology-Based Strategy to Decode the Synergistic Mechanism of Zhi-zhu Wan for Functional Dyspepsia

et al. 2018

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Functional dyspepsia (FD) is a widely prevalent gastrointestinal disorder throughout the world, whereas the efficacy of current treatment in the Western countries is limited. As the symptom is equivalent to the traditional Chinese medicine (TCM) term “stuffiness and fullness,” FD can be treated with Zhi-zhu Wan (ZZW) which is a kind of Chinese patent medicine. However, the “multi-component” and “multi-target” feature of Chinese patent medicine makes it challenge to elucidate the potential therapeutic mechanisms of ZZW on FD. Presently, a novel system pharmacology model including pharmacokinetic parameters, pharmacological data, and component contribution score (CS) is constructed to decipher the potential therapeutic mechanism of ZZW on FD. Finally, 61 components with favorable pharmacokinetic profiles and biological activities were obtained through ADME (absorption, distribution, metabolism, and excretion) screening in silico. The related targets of these components are identified by component targeting process followed by GO analysis and pathway enrichment analysis. And systematic analysis found that through acting on the target related to inflammation, gastrointestinal peristalsis, and mental disorder, ZZW plays a synergistic and complementary effect on FD at the pathway level. Furthermore, the component CS showed that 29 components contributed 90.18% of the total CS values of ZZW for the FD treatment, which suggested that the effective therapeutic effects of ZZW for FD are derived from all active components, not a few components. This study proposes the system pharmacology method and discovers the potent combination therapeutic mechanisms of ZZW for FD. This strategy will provide a reference method for other TCM mechanism research.

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“…Other polyphenolic compounds have been reported to exert beneficial effects on NP, such as hesperidin [51], diosmin [52], naringenin [53].…”

Section: Future Perspectives In Treatment Of Painmentioning

confidence: 99%

Anti-Inflammatory and Anti-Nociceptive Effects of Cocoa: A Review on Future Perspectives in Treatment of Pain

et al. 2020

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Cocoa has been reported to have medicinal properties. It contains a wide range of phytochemicals, including polyphenols, which have been shown to exert anti-inflammatory and antioxidant actions, and also to have a positive effect on pain. Other components of cocoa might be able to positively influence pain perception through various mechanisms. Despite encouraging results from preclinical studies, there is a lack of evidence of antinociceptive effects of cocoa from clinical trials in humans. Further research is needed to better identify the active principles in cocoa, to understand the underlying mechanisms of action, and to establish efficacy in humans.

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Naringenin: an analgesic and anti-inflammatory citrus flavanone

Cited by 71 publications

References 8 publications

Phytochemicals That Influence Gut Microbiota as Prophylactics and for the Treatment of Obesity and Inflammatory Diseases

Phytochemicals That Influence Gut Microbiota as Prophylactics and for the Treatment of Obesity and Inflammatory Diseases

System Pharmacology-Based Strategy to Decode the Synergistic Mechanism of Zhi-zhu Wan for Functional Dyspepsia

Anti-Inflammatory and Anti-Nociceptive Effects of Cocoa: A Review on Future Perspectives in Treatment of Pain

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