Naringenin – a potential nephroprotective agent for diabetic kidney disease: A comprehensive review of scientific evidence
Estefania Valle-Velázquez,
Oscar René Zambrano-Vásquez,
Fernando Cortés-Camacho
et al.
Abstract:Diabetes mellitus (DM) is a chronic disease characterized by persistent hyperglycemia, which is a major contributing factor to chronic kidney disease (CKD), end-stage renal disease (ESRD), and cardiovascular-related deaths. There are several mechanisms leading to kidney injury, with hyperglycemia well known to stimulate oxidative stress, inflammation, tissue remodeling, and dysfunction in the vascular system and organs. Increased reactive oxygen species (ROS) decrease the bioavailability of vasodilators while … Show more
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