Naringenin: A potential flavonoid phytochemical for cancer therapy

Motallebi, Mahzad; Bhia, Mohammed; Rajani, Huda Fatima; Bhia, Iman; Tabarraei, Hadi; Mohammadkhani, Niloufar; Pereira-Silva, Miguel; Kasaii, Maryam Sadat; Nouri-Majd, Saeedeh; Mueller, Anna-Lena; Veiga, Francisco; Paiva‐Santos, Ana Cláudia; Shakibaei, Mehdi

doi:10.1016/j.lfs.2022.120752

Cited by 111 publications

(70 citation statements)

References 183 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Tomatoes and tomato products were found to have anticancer activity, especially against prostate cancer, and lycopene was identified as the main active compound [ 27 ]. Naringenin, present for example in tomatoes, was effective in the treatment of various malignancies, including breast cancer [ 28 ]. The extract of aloe was cytotoxic to human cancer cells, including breast cancer cells [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Extracts of Common Vegetables Inhibit the Growth of Ovary Cancer Cells

Furdak

Pieńkowska

Bartosz

et al. 2022

Foods

View full text Add to dashboard Cite

There is recent interest in a diet that can be recommended for patients suffering from cancer. In this respect, the effects were studied of the extracts of several common fruits, herbs and vegetables on the viability of two human ovary cancer cell lines (SKOV-3 and PEO1) in vitro. Normal human MRC-5 fibroblasts were used as a control cell line. The extracts of garlic, horseradish and curly kale as well as green and black tea were the most effective in lowering the viability of ovarian cancer cells, while not affecting the viability of MRC-5 fibroblasts. Except for garlic and horseradish, the cytotoxic effects of the extracts correlated with their polyphenol content. The examination of changes in the content of ATP and glutathione, in the level of reactive oxygen species, mitochondrial potential and mitochondrial mass did not show a consistent pattern, suggesting that various extracts may act via different mechanisms. Although the extracts’ toxicity to cells in vitro is a first and direct suggestion concerning their possible anticancer effects in vivo, these results point to potential vegetable candidates to become diet components recommended for ovary cancer patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Extracts of Common Vegetables Inhibit the Growth of Ovary Cancer Cells

Furdak

Pieńkowska

Bartosz

et al. 2022

Foods

View full text Add to dashboard Cite

show abstract

“…Myricetin-mediated cytotoxicity was observed in triple-negative breast cancer cells due to oxidative stress: autoxidation of 50 µM myricetin in the growth medium led to extracellular H 2 O 2 formation and triggered intracellular ROS production, ultimately causing DNA damage [274]. Naringenin, as well, has been demonstrated to be effective against a wide range of tumor types by suppressing cancer progression programs [275]. Genistein, an isoflavonoid present in soy-derived foods, was hypothesized to reduce SARS-CoV-2 infectivity by inhibiting the virus strategy for entrance in human epithelium [276].…”

Section: Flavonoids As Nutraceuticals and Prebiotics For Human Healthmentioning

confidence: 99%

Flavonoids Are Intra- and Inter-Kingdom Modulator Signals

et al. 2022

View full text Add to dashboard Cite

Flavonoids are a broad class of secondary metabolites with multifaceted functionalities for plant homeostasis and are involved in facing both biotic and abiotic stresses to sustain plant growth and health. Furthermore, they were discovered as mediators of plant networking with the surrounding environment, showing a surprising ability to perform as signaling compounds for a multitrophic inter-kingdom level of communication that influences the plant host at the phytobiome scale. Flavonoids orchestrate plant-neighboring plant allelopathic interactions, recruit beneficial bacteria and mycorrhizal fungi, counteract pathogen outbreak, influence soil microbiome and affect plant physiology to improve its resilience to fluctuating environmental conditions. This review focuses on the diversified spectrum of flavonoid functions in plants under a variety of stresses in the modulation of plant morphogenesis in response to environmental clues, as well as their role as inter-kingdom signaling molecules with micro- and macroorganisms. Regarding the latter, the review addresses flavonoids as key phytochemicals in the human diet, considering their abundance in fruits and edible plants. Recent evidence highlights their role as nutraceuticals, probiotics and as promising new drugs for the treatment of several pathologies.

show abstract

“…Several in vitro and in vivo studies have shown that flavonoids, especially flavanones, the main class of flavonoids in citrus extracts, such as naringin and naringenin [ 22 , 28 ], possess antiproliferative, anti-inflammatory, and pro-apoptotic properties [ 29 , 30 , 31 , 32 , 33 , 34 ]. Other compounds found in citrus fruits that have demonstrated potential anticancer effects include quercetin [ 15 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ], hesperidin [ 42 , 43 , 44 ], hesperetin [ 45 , 46 ], polymethoxyflavones [ 47 , 48 , 49 ], eriodyctiol [ 50 , 51 ], bergapten [ 52 , 53 ], tangeretin [ 54 , 55 ], auraptene [ 56 , 57 , 58 ], limonin [ 59 ], naringenin [ 60 , 61 , 62 , 63 , 64 , 65 ], and naringin [ 66 , 67 , 68 ], as shown in ( Table 1 ). These findings suggest a potential role for flavonoids in cancer therapy, including breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Naringenin and Hesperidin as Promising Alternatives for Prevention and Co-Adjuvant Therapy for Breast Cancer

et al. 2023

View full text Add to dashboard Cite

Citrus (genus Citrus L.) fruits are essential sources of bioactive compounds with antioxidant properties, such as flavonoids. These polyphenolic compounds are divided into subclasses, in which flavanones are the most prominent. Among them, naringenin and hesperidin are emerging compounds with anticancer potential, especially for breast cancer (BC). Several mechanisms have been proposed, including the modulation of epigenetics, estrogen signaling, induction of cell death via regulation of apoptotic signaling pathways, and inhibition of tumor invasion and metastasis. However, this information is sparse in the literature and needs to be brought together to provide an overview of how naringenin and hesperidin can serve as therapeutic tools for drug development and as a successful co-adjuvant strategy against BC. This review detailed such mechanisms in this context and highlighted how naringenin and hesperidin could interfere in BC carcinogenesis and be helpful as potential alternative therapeutic sources for breast cancer treatment.

show abstract

Naringenin: A potential flavonoid phytochemical for cancer therapy

Cited by 111 publications

References 183 publications

Extracts of Common Vegetables Inhibit the Growth of Ovary Cancer Cells

Extracts of Common Vegetables Inhibit the Growth of Ovary Cancer Cells

Flavonoids Are Intra- and Inter-Kingdom Modulator Signals

Naringenin and Hesperidin as Promising Alternatives for Prevention and Co-Adjuvant Therapy for Breast Cancer

Contact Info

Product

Resources

About