Nardostachin, an Iridoid of<i>Nardostachys chinensis</i><sup>1</sup>

Bagchi, Anjana; Oshima, Yoshiteru; Hikino, Hiroshi

doi:10.1055/s-2006-962351

Cited by 21 publications

(52 citation statements)

References 5 publications

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“…Similarly, sesquiterpenes such as aristolene, â-maaliene, isonardosione, nardostachin, nardofuran, nardoquaianone (3,(20)(21)(22) have been reported in N. chinensis.…”

Section: Resultsmentioning

confidence: 85%

Quality assessment of the essential oils from Nardostachys jatamansi (d. Don) dc and Nardostachys chinensis batal obtained from Kathmandu valley market

Paudyal¹,

Rajbhandari

Basnet

et al. 2012

Sci World

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The chemical composition and physicochemical parameters of the essential oils obtained from two species of Nardostachys available in Kathmandu market, N. jatamansi (D. Don) and N. chinensis Batal were determined. GC-MS technique was used for the analysis of the oils. Both oils were characterized by high content of sesquiterpenes. â-gurjunene and jatamansone were the major sesquiterpene components of both oils. Somewhat variation in the amount of chemical components was found in two different species. The physical and chemical parameters such as specific gravity, specific rotation, refractive index and saponification value, acid number, iodine number were very similar for both species. Both oils were, therefore, of comparable quality. Scientific World, Vol. 10, No. 10, July 2012 p13-16 DOI: http://dx.doi.org/10.3126/sw.v10i10.6854

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“…Similarly, sesquiterpenes such as aristolene, â-maaliene, isonardosione, nardostachin, nardofuran, nardoquaianone (3,(20)(21)(22) have been reported in N. chinensis.…”

Section: Resultsmentioning

confidence: 85%

Quality assessment of the essential oils from Nardostachys jatamansi (d. Don) dc and Nardostachys chinensis batal obtained from Kathmandu valley market

Paudyal¹,

Rajbhandari

Basnet

et al. 2012

Sci World

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“…Several compounds extracted from it have been identified, including nardosinone, 13) guaiane-and aristolane-type sesquiterpenoids 14) and nardostachin. 15) However, Li et al showed that only nardosinone actively enhances the effects of NGF, staurosporine and dibutyryl cyclic AMP 16) on the differentiation of PC12 cells. In the present study, glycoside from Nardostachys chinensis BATALIN was shown to induce the characteristics of neuronal differentiation in PC12 cells, including neurite outgrowth, increased AChE activity, arrest of the cell cycle in G1 and specific up-regulation of the expression of the neuronal marker GAP-43.…”

Section: Discussionmentioning

confidence: 99%

Nardostachys chinensis Glycoside Induces Characteristics of Neuronal Differentiation in Rat Pheochromocytoma PC12 Cells

Liu

Yin

Zheng

2005

Biological & Pharmaceutical Bulletin

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Rat pheochromocytoma PC12 cells undergo neuronal differentiation in response to nerve growth factor. We show here that exposure of PC12 cells to Nardostachys chinensis glycoside induces the outgrowth of neurites, increases the activity of AChE, triggers cell cycle arrest in G1 and enhances the expression of growth associated protein 43 (GAP-43). Both the outgrowth of neurites and the increase in AChE activity are prevented partly by PD98059, a specific inhibitor of MEK1. These results suggest that N. chinensis glycoside induces the characteristics of neuronal differentiation in PC12 cells via the mitogen-activated protein kinase (MAPK)-related signal cascade.Key words Nardostachys chinensis glycoside; acetylcholinesterase; mitogen-activated protein kinase; neurite Ever since nerve growth factor (NGF) was found to be a potent inducer of neurite outgrowth and network development in rat pheochromocytoma PC12 cells, this cell line has been recognized as a good in vitro model for studying neuronal differentiation processes.1) Other compounds have been shown to induce neurite outgrowth in these cultured cells, including several cell adhesion molecules, constituents of the extracellular matrix, 2) certain polypeptides 3) and numerous plant substances such as Cuscuta chinensis glycoside, 4) lignans, 5) lipophilic extracts of Panax ginseng 6) and quinic acids. 7) Such low molecular weight compounds might be of more pharmaceutical use than NGF for treating various neurodegenerative diseases, since they are capable of passing through the blood-brain barrier and are not easily degraded. As part of our search for substances that induce NGF-like differentiation in PC12 cells, several extracts of traditional Chinese medicines were tested. We found that a glycoside from Nardostachys chinensis performed well.Extensive studies have been made of the characteristics of neuronal differentiation and signal cascades associated with NGF-induced neuronal differentiation in PC12 cells. Exposure of these cells to NGF activates the GTP-binding protein, Ras, initiating a number of signaling cascades including the Raf/MEK/MAP kinase pathway. 8) These factors ultimately induce neuronal differentiation, which is recognizable by neurite outgrowth, increased AChE activity, cell cycle arrest in G1 9) and induction of neuronal markers such as growth associated protein 43 (GAP-43).10) In the present study, we investigated the effect of N. chinensis glycoside on these indicators of differentiation. Neuronal differentiation of PC12 cells in response to neurotrophic factors is apparently mediated via mitogen-activated protein kinase (MAPK)-dependent signaling pathway, 11) so the effects of PD98059, a specific inhibitor of MAPK kinase, were also examined. MATERIALS AND METHODSMaterials Poly-L-lysine and 7s NGF were purchased from Sigma. Dulbecco's modified Eagle's medium (DMEM, high glucose), fetal bovine serum (FBS) and horse serum (HS) were purchased from Gibco. PD98059 (Calbiochem Co.) was dissolved in dimethylsulfoxide and stored in aliquots at Ϫ20...

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“…Only one preliminary culture study has been conducted to investigate the attenuating action of nardostachin in preventing D-galactosamineproduced liver damage and carbon tetrachloride-induced hepatotoxicity in rat hepatocytes. At 0.1-1 mg/ml, nardostachin produced pronounced effect against D-galactosamine-produced liver damage and weaker effect against carbon tetrachloride-induced hepatotoxicity in the culture medium (Bagchi et al, 1988c).…”

Section: Hepatoprotective Activitymentioning

confidence: 94%

Nardostachys chinensis Batalin: A review of traditional uses, phytochemistry, and pharmacology

Rehman

Ahmad

2019

Phytotherapy Research

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Nardostachys chinensis Batalin (Valerianaceae) has been widely used in different traditional systems of medicine, including Islamic, Ayurvedic, Chinese, and Korean folk medicine. It has been used in traditional medicine as a tranquilizer, hepatotonic, cardiotonic, diuretic, and analgesic. Preliminary in vitro and in vivo studies have provided valuable scientific evidence for its traditional uses. This review aims to summarize reported traditional uses, phytochemistry, and pharmacological potential of N. chinensis while identifying potential areas of further research of plant. The review comprises literature pertaining to the pharmacological potential and phytochemistry of N. chinensis using worldwide accepted scientific databases via electronic search (Elsevier, Google Scholar, Pub Med, Scopus, Springer, Wiley online library). Moreover, data from ethno botanical text books available in library and electronic search were also included. The Plant List and Kew Herbarium Catalogue databases were used to authenticate the scientific name. Different pharmacological experiments in many in vitro and in vivo models have proved the potential of N. chinensis, namely, antiinflammatory, anticonvulsant, antibacterial, antihypertensive, antifungal, neuroprotective, cardioprotective, aldose reductase inhibition, and antioxidant activities. The plant contains sesquiterpenenes of various varieties including aristolane, guaiane, and nardosinane types. Moreover, it also contains coumarins, phenols, lignans, neolignans, and glycosides. Reported activities suggested that there may be pharmacological potential for developing N. chinensis as a drug for infections, hypertension, cardiac diseases, Alzheimer's disease, insomnia, epilepsy, cancer, gastric, and liver diseases. More toxicological studies should be performed that will aid the progress to clinical trial studies of N. chinensis. Abbreviations: 2K1C, two-kidney one-clip; 5-HT, 5-hydroxytryptamine; ABTS, 2,2′-azino-bis; AChEI, acetylcholinesterase; BChE, butyrylcholinesterase; Bcl-2, B-cell lymphoma 2; CDK, cyclindependent kinase; dbcAMP, dibutyryl cyclic adenosine mono phosphate; Dct, dopachrometautomerase; DPPH, 2,2, diphenyly 1-picryl hydrazyl; EGF, epidermal growth factor; ERK, extracellular signal-regulated kinase; EV, estradiol valerate; FRAP, ferric reducing antioxidant power; GAP-43, growth associated protein 43; ICAM-1, intracellular cell adhesion molecule 1; IP-10, interferon gamma-induced protein 10; I-TAC, interferon-inducible T-cell alpha chemo attractant; IVSd, interventricular septal diameter at end-diastole; IVSs, interventricular septal diameter at end-systole; LDL, low-density lipoprotein; LPS, lipopolysaccharide; LTA, lipoteichoic acid; LVEF, left ventricular ejection fraction; LVFS, left ventricular fractional shortening; LVIDd, left ventricular internal diameter at end-diastole; LVIDs, left ventricular internal diameter at end-systole; LVPWd, left ventricular posterior wall at end-diastole; LVPWs, left ventricular posteriorwall at end-systole; LVW/BW, left vent...

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Nardostachin, an Iridoid ofNardostachys chinensis¹

Cited by 21 publications

References 5 publications

Quality assessment of the essential oils from Nardostachys jatamansi (d. Don) dc and Nardostachys chinensis batal obtained from Kathmandu valley market

Quality assessment of the essential oils from Nardostachys jatamansi (d. Don) dc and Nardostachys chinensis batal obtained from Kathmandu valley market

Nardostachys chinensis Glycoside Induces Characteristics of Neuronal Differentiation in Rat Pheochromocytoma PC12 Cells

Nardostachys chinensis Batalin: A review of traditional uses, phytochemistry, and pharmacology

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Nardostachin, an Iridoid ofNardostachys chinensis1

Cited by 21 publications

References 5 publications

Quality assessment of the essential oils from Nardostachys jatamansi (d. Don) dc and Nardostachys chinensis batal obtained from Kathmandu valley market

Quality assessment of the essential oils from Nardostachys jatamansi (d. Don) dc and Nardostachys chinensis batal obtained from Kathmandu valley market

Nardostachys chinensis Glycoside Induces Characteristics of Neuronal Differentiation in Rat Pheochromocytoma PC12 Cells

Nardostachys chinensis Batalin: A review of traditional uses, phytochemistry, and pharmacology

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Product

Resources

About

Nardostachin, an Iridoid ofNardostachys chinensis¹