Narcolepsy with cataplexy in patients aged over 60 years: a case-control study

Kovalská, Petra; Kemlink, David; Nevšímalová, Soňa; Horvat, Eszter Maurovich; Jarolímová, Eva; Topinková, Eva; Šonka, Karel

doi:10.1016/j.sleep.2016.05.011

Cited by 19 publications

(9 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most frequently used questionnaire was the SF36, which was utilised in 22 of the 30 studies (Table 1). The EQ5D was used to assess HRQoL in six studies (Dauvilliers et al., 2017, 2019; Dodel et al., 2007; Emsellem et al., 2020; Ingravallo et al., 2012; Kovalska et al., 2016), and the FOSQ was used in five studies (Dauvilliers et al., 2011; Emsellem et al., 2020; Kapella et al., 2015; Teixeira, Faccenda, & Douglas, 2004; Weaver & Cuellar, 2006). The remaining questionnaires were used in singular studies (Table 1).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Health‐related quality of life in narcolepsy: A systematic review and meta‐analysis

Tadrous

O’Rourke

Mockler

et al. 2021

Journal of Sleep Research

View full text Add to dashboard Cite

Summary To date, there has been no systematic analysis of the literature regarding health‐related quality of life in narcolepsy. This systematic review aimed to examine the impact of narcolepsy on health‐related quality of life, measured through standardised health‐related quality of life questionnaires such as the Short Form 36 and Functional Outcome of Sleep Questionnaire. The following databases: Medline, Embase, Cinahl, and Web of Science were searched for studies that investigated health‐related quality of life in adults with narcolepsy. Studies were reviewed independently by two reviewers, and a random‐effects meta‐analysis was performed. A total of 30 studies were eligible for inclusion in the review. Additionally, meta‐analyses were conducted for the Short Form 36 and the EQ5D. The Short Form 36 meta‐analysis identified that the pooled mean scores for the Physical Component Summary (45.91) were less affected than the Mental Component Summary (42.98). People with narcolepsy experience substantially lower health‐related quality of life when compared with the general population norms of the USA, UK, France and Norway, as well as compared with people with chronic diseases such as multiple sclerosis, diabetes, hypertension and epilepsy. Further research is warranted to identify the longitudinal effects of narcolepsy on health‐related quality of life, and to develop a narcolepsy‐specific health‐related quality of life tool.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Five studies reported employment‐related difficulties experienced by respondents (Flores et al., 2016; Ingravallo et al., 2012; Kapella et al., 2015; Kovalska et al., 2016; Teixeira et al., 2004). Changes of employment were reported by the working population of the sample recruited by Ingravallo et al.…”

Section: Resultsmentioning

confidence: 99%

Health‐related quality of life in narcolepsy: A systematic review and meta‐analysis

Tadrous

O’Rourke

Mockler

et al. 2021

Journal of Sleep Research

View full text Add to dashboard Cite

show abstract

“…We did not find any major differences in social activities and quality of life in comparison to controls. However, NT1 subjects suffered from more frequent type 2 diabetes, arterial hypertension, and obesity and had lower physical fitness in old age [10].…”

Section: Discussionmentioning

confidence: 99%

Rare Case of Late-Onset Narcolepsy Type 1

Kovalská

Dostálová

Machová³

et al. 2020

Case Rep Neurol

Self Cite

View full text Add to dashboard Cite

A 69-year-old male developed symptoms typical of the diagnosis of narcolepsy type 1 without any previous triggering events. First, daytime sleepiness occurred, soon followed by cataplexy. Nocturnal polysomnography revealed rapid eye movement (REM) sleep behavior disorder, a apnea-hypopnea index of 25.8 events/h, and no sleep-onset REM. Multiple Sleep Latency Test showed a mean sleep latency of 2.1 min and REM sleep in 3 tests. HLA DQB1*06:02 was positive and hypocretin-1 in cerebrospinal fluid unmeasurable. A treatment with 50 mg clomipramine controlled the cataplexy; excessive daytime sleepiness was sufficiently managed by repeated naps. The administration of 0.25 mg of clonazepam subjectively improved REM sleep behavior disorder. Bilevel Positive Airway Pressure improved the apnea-hypopnea index without important influence on sleepiness. Our unique case demonstrates that even elderly subjects can develop narcolepsy type 1.

show abstract

“…We found a negative correlation between the anterior hippocampus volume and the duration of the disease. This is surprising, because NC is supposed to be a stable chronic disease with no clinically significant deterioration over time (Kovalska et al., ). It might be assumed that morphological changes would be more apparent in patients suffering from the disease for a longer period of time.…”

Section: Discussionmentioning

confidence: 99%

Anterior hippocampus volume loss in narcolepsy with cataplexy

Křečková

Kemlink

Šonka

et al. 2018

Journal of Sleep Research

Self Cite

View full text Add to dashboard Cite

Narcolepsy with cataplexy is a lifelong disease resulting from the loss of hypocretin neurons in the hypothalamus; structural changes are not, however, limited only to the hypothalamus. We previously revealed an overall hippocampal volume loss in narcolepsy with cataplexy. The aim of this study is to describe the volume reduction of the anterior and posterior parts of the hippocampus in patients with narcolepsy with cataplexy in comparison with a control group. The anterior hippocampus is more involved in episodic memory and imagination, and the posterior hippocampus in spatial memory. Manual magnetic resonance imaging hippocampal volumetry was performed in 48 patients with narcolepsy with cataplexy and in 37 controls using the manual delineation technique in the ScanView program. All participants were examined on the same 1.5 T MR scanner; measurement was carried out as T1W 3D image with a slice thickness of 1.0/0 mm. There was a significant absolute loss of the total volume of the anterior hippocampus (sum of left and right) in patients with narcolepsy with cataplexy as compared with the controls (10.5%, p = .03 ANCOVA after correcting for total brain volume and multiple testing). We found a negative correlation between the total anterior hippocampus volume and the duration of the disease (R = −0.4036, p = .016—corrected for multiple testing).

show abstract

Narcolepsy with cataplexy in patients aged over 60 years: a case-control study

Cited by 19 publications

References 32 publications

Health‐related quality of life in narcolepsy: A systematic review and meta‐analysis

Health‐related quality of life in narcolepsy: A systematic review and meta‐analysis

Rare Case of Late-Onset Narcolepsy Type 1

Anterior hippocampus volume loss in narcolepsy with cataplexy

Contact Info

Product

Resources

About