Narcolepsy and Predictors of Positive MSLTs in the Wisconsin Sleep Cohort

Goldbart, Aviv; Peppard, Paul E.; Finn, Laurel; Ruoff, Chad; Barnet, Jodi H.; Young, Terry; Mignot, Emmanuel

doi:10.5665/sleep.3758

Cited by 110 publications

(82 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although done for simplicity, this change altered the sensitivity and specificity of the MSLT differentially for these disorders, and was recognized as being highly debatable at the time [38]. A perhaps unintended consequence of simplifying the ICSD was to create a de facto cutpoint to delineate pathologic from subjective sleepiness, which may have limited utility in a number of disorders, particularly since a sizeable proportion of the general population will demonstrate MSL values below this cutpoint [39]. …”

Section: Discussionmentioning

confidence: 99%

Sleep propensity in psychiatric hypersomnolence: A systematic review and meta-analysis of multiple sleep latency test findings

Plante

2017

Sleep Medicine Reviews

View full text Add to dashboard Cite

SUMMARY Hypersomnolence plays a sizeable role in the course and morbidity of psychiatric disorders. Current sleep medicine nosology is reliant on the multiple sleep latency test (MSLT) to segregate hypersomnolence associated with psychiatric disorders from other central nervous system causes. However, the evidence base regarding sleep propensity in psychiatric hypersomnolence as measured by the MSLT has not been systematically evaluated, which is vital to clarify the utility and validity of current nosological schema. In this review, the use of sleep propensity assessed by the MSLT in patients with psychiatric hypersomnolence is systematically evaluated, using both qualitative and quantitative assessment. Findings demonstrate high heterogeneity and potential for bias among studies, with a pooled estimate of sleep propensity among patients with psychiatric hypersomnolence similar to normative values. Additionally, approximately 25% of patients with psychiatric hypersomnolence demonstrate a mean sleep latency below 8 minutes, the current cutpoint to define pathologic sleepiness. These data underscore the limitations of the MSLT in segregating psychiatric hypersomnolence from other central nervous system hypersomnias. Further research is warranted to evaluate novel measures and biomarkers of excessive sleepiness to advance clinical practice, as well as dimensional approaches to classification of hypersomnolence disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

Sleep propensity in psychiatric hypersomnolence: A systematic review and meta-analysis of multiple sleep latency test findings

Plante

2017

Sleep Medicine Reviews

View full text Add to dashboard Cite

show abstract

“…The PSG-MSLT must be performed in a sleep laboratory, most notably because a valid MSLT mandates that the subject does not sleep between daytime naps. In addition, the patient must have been shown to have regular, sufficient sleep during nighttime hours before testing (shift workers are particularly at risk of false positives) [17], and the patient has to have been free of any stimulant or antidepressant treatment for at least a week. Although the sensitivity and specificity of this revised ICSD-3 PSG-MSLT criteria have not been formally analyzed, they are likely to remain similar to those of the ICSD-2 MSLT alone.…”

Section: Introductionmentioning

confidence: 99%

Sleep-stage transitions during polysomnographic recordings as diagnostic features of type 1 narcolepsy

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…High test-retest reliability of MSLT has been demonstrated over the short term (weeks to months) in patients with narcolepsy and in healthy subjects [1, 2]. In contrast, test-retest reliability in general population as well as in patients with narcolepsy without cataplexy or idiopathic hypersomnia are low over the long term (years) [3, 4]. In practice it is common to see conflicting results from subsequent MSLTs, leading to diagnostic uncertainty.…”

Section: Introductionmentioning

confidence: 99%

Test–retest reliability of two consecutive mean sleep latency tests in patients with hypersomnia

Kwon

Kazaglis

Cho

et al. 2017

Sleep Biol. Rhythms

View full text Add to dashboard Cite

Reliability of mean sleep latency testing (MSLT) over consecutive days in patients with hypersomnia is unknown. We reviewed MSLTs of patients with hypersomnia without cataplexy who underwent our two consecutive MSLT protocol (N=29). Average MSLs were 10.9 and 10.9 minutes for days 1 and 2, respectively. Agreement for pathological hypersomnia (defined as MSL≤8 minutes) between MSLT days showed k=0.85 for all (N=29) and k=0.76 for those without sleep apnea (N=20). In patients with subjective complaints of hypersomnia, a single MSLT is sufficient (vs. addition of 2nd day MSLT) in the setting of carefully implemented protocol controlling for potential confounding variables.

show abstract

Narcolepsy and Predictors of Positive MSLTs in the Wisconsin Sleep Cohort

Abstract: The diagnostic value of multiple sleep latency tests is strongly altered by shift work and to a lesser extent by chronic sleep deprivation. The prevalence of narcolepsy without cataplexy may be 3-fold higher than that of narcolepsy-cataplexy.

Cited by 110 publications

References 39 publications

Sleep propensity in psychiatric hypersomnolence: A systematic review and meta-analysis of multiple sleep latency test findings

Sleep propensity in psychiatric hypersomnolence: A systematic review and meta-analysis of multiple sleep latency test findings

Sleep-stage transitions during polysomnographic recordings as diagnostic features of type 1 narcolepsy

Test–retest reliability of two consecutive mean sleep latency tests in patients with hypersomnia

Contact Info

Product

Resources

About