Narcissistic aggregation of steroid compounds in diluted solution elucidated by CSI-MS, PFG NMR and X-ray analysis

Shikii, Kazuaki; Sakamoto, Shigeru; Seki, Hiroko; Utsumi, Hiroaki; Yamaguchi, Kentaro

doi:10.1016/j.tet.2004.02.030

Cited by 40 publications

(38 citation statements)

References 16 publications

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“…The diffusion coefficients for progesterone and estradiol in the aqueous solution were 5.56 Â 10 j6 and 5.18 Â 10 j6 cm 2 /s, respectively, similar to values previously reported (23,28). Solubilization of progesterone and estradiol by microemulsion lipid assemblies decreased diffusivity of the drug by as much as much as 50-fold as compared with that observed in aqueous solutions.…”

Section: Examplessupporting

confidence: 87%

Mass Transport Properties of Progesterone and Estradiol in Model Microemulsion Formulations

Land

Bummer

2006

Pharm Res

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In systems nearly saturated with drug, the microemulsion formulation leads to a greatly enhanced rate of steady-state mass transport while in systems with drug loading far from saturation, the microemulsion formulation appears to have a minimal ability to promote mass transport. The aqueous boundary layer diffusion model was successful in fitting progesterone results but was not successful for estradiol.

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Section: Examplessupporting

confidence: 87%

Mass Transport Properties of Progesterone and Estradiol in Model Microemulsion Formulations

Land

Bummer

2006

Pharm Res

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“…This value is slightly higher than values previously reported in water [10][11][12]. But, the presence of ethanol in this media could provoke an increase in diffusion coefficient.…”

Section: Determination Of the Diffusion Coefficient Of Estradiol-cd Ccontrasting

confidence: 61%

Chronocoulometry diffusion coefficients as a measure of cyclodextrin–estradiol complex association

Yáñez

Basquinzay

2008

Journal of Electroanalytical Chemistry

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“…analysis. Data were obtained from the CIF files reported by Shikii et al for progesterone [61], and Shieh et al for cholesterol [62]. Since the asymmetric unit in the crystal of cholesterol has eight molecules, mean values of bond distances and bond angles were calculated for comparison purposes.…”

Section: Standard Steroidmentioning

confidence: 99%

A Standard Structure for Bile Acids and Derivatives

et al. 2018

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Abstract:The crystal structures of two ester compounds (a monomer in its methyl ester form, with an amino isophthalic group, and a dimer in which the two steroid units are linked by a urea bridge recrystallized from ethyl acetate/methanol) derived from cholic acid are described. Average bond lengths and bond angles from the crystal structures of 26 monomers and four dimers (some of them in several solvents) of bile acids and esters (and derivatives) are used for proposing a standard steroid nucleus. The hydrogen bond network and conformation of the lateral chain are also discussed. This standard structure was used to compare with the structures of both progesterone and cholesterol.

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Narcissistic aggregation of steroid compounds in diluted solution elucidated by CSI-MS, PFG NMR and X-ray analysis

Cited by 40 publications

References 16 publications

Mass Transport Properties of Progesterone and Estradiol in Model Microemulsion Formulations

Mass Transport Properties of Progesterone and Estradiol in Model Microemulsion Formulations

Chronocoulometry diffusion coefficients as a measure of cyclodextrin–estradiol complex association

A Standard Structure for Bile Acids and Derivatives

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