Narcissin induces developmental toxicity and cardiotoxicity in zebrafish embryos via Nrf2/HO‐1 and calcium signaling pathways
Shuo Gao,
Chaoyi Zhou,
Linhua Hou
et al.
Abstract:Narcissin is a natural flavonoid from some edible and traditional medicinal plants. It has been proven to have multiple biological functions and exhibits potential therapeutic effects on hypertension, cancer, and Alzheimer's disease. However, the toxicity of narcissin is largely unknown. Here, we revealed that narcissin treatment led to reduced hatchability, increased malformation rate, shorter body length, and slowed blood flow in zebrafish. Furthermore, bradycardia, pericardial edema, increased SV‐BA distanc… Show more
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