2022
DOI: 10.3390/polym14030450
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Naproxen-Loaded Poly(2-hydroxyalkyl methacrylates): Preparation and Drug Release Dynamics

Abstract: Poly(2-hydroxyethylmethacrylate)/Naproxen (NPX/pHEMA) and poly (2-hydroxypropyl methacrylate)/Naproxen (NPX/pHPMA) composites with different NPX content were prepared in situ by free radical photopolymerization route. The resulted hybrid materials were characterized by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), scanning Electron microscopy (SEM), and X-ray diffraction (XRD). These composites have been studied as drug carrier systems, in which a comparison of the in… Show more

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Cited by 6 publications
(3 citation statements)
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References 56 publications
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“…The most distinct and well-defined peaks in the range from 2300–1750 cm −1 (marked red areas) could be related to the base material (i.e., D1) and correspond to the stretching vibration of the methylene groups (-CH 2 ) at 2250 cm −1 and the stretching of the ester bonds of the methacrylic and ethyl acrylic groups between 2100 and 1750 cm −1 [ 48 , 103 ]. The position of the vibrational peaks of the carbonyl groups (C=O) at about 1750 cm −1 indicates the formation of intermolecular hydrogen bonds in the structure of D1 [ 104 ]. Regardless of the actual nature of the vibrations, the visible increase in the intensity of typical peaks with the subsequent layers suggests that an LbL structure was successfully generated using the spin coating technique.…”
Section: Resultsmentioning
confidence: 99%
“…The most distinct and well-defined peaks in the range from 2300–1750 cm −1 (marked red areas) could be related to the base material (i.e., D1) and correspond to the stretching vibration of the methylene groups (-CH 2 ) at 2250 cm −1 and the stretching of the ester bonds of the methacrylic and ethyl acrylic groups between 2100 and 1750 cm −1 [ 48 , 103 ]. The position of the vibrational peaks of the carbonyl groups (C=O) at about 1750 cm −1 indicates the formation of intermolecular hydrogen bonds in the structure of D1 [ 104 ]. Regardless of the actual nature of the vibrations, the visible increase in the intensity of typical peaks with the subsequent layers suggests that an LbL structure was successfully generated using the spin coating technique.…”
Section: Resultsmentioning
confidence: 99%
“…[30] In addition, naproxen and mefenamic non-steroidal anti-inflammatory drugs (NSAIDs) are known to have anti-proliferative activity against various cancers. [40][41][42][43][44] As we are interested in improving the biological activity of Janus dendrimers, in the present study, we set out to develop a straightforward strategy for the synthesis of Janus dendrimers, where one dendron conjugated with naproxen via a triethylene glycol linker and the other dendron based on L-lysine-aminobutanoic acid conjugate with mefenamic acid. The dendrimer was obtained by following two protection-deprotection steps.…”
Section: Introductionmentioning
confidence: 99%
“…Janus dendrimers with tris(hydroxymethyl)‐aminomethane (Tris) naproxen conjugates showed toxicity against cancer cells [30] . In addition, naproxen and mefenamic non‐steroidal anti‐inflammatory drugs (NSAIDs) are known to have anti‐proliferative activity against various cancers [40–44] …”
Section: Introductionmentioning
confidence: 99%