Naphthoquinones and triterpenes from african Diospyros species

Zhong, Shouming; Waterman, Peter G.; Jeffreys, J. A. D.

doi:10.1016/s0031-9422(00)82610-2

Cited by 70 publications

(27 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The plant (9.5 g) was extracted with 300 ml of chloroform by different extraction techniques: static maceration (24h), dynamic maceration (10h + 14h of static maceration), extraction with aid of ultrasonic waves (2h) and extraction in the Soxhlet apparatus at different process duration (2h, 5h, 10h). Chloroform was employed as solvent for these extractions, once it was reported in literature for nafthoquinones extraction (Sidhu and Sankaram 1971, Zhong et al 1984, Pakulski and Budzianowski 1996. All the solutions were evaporated to dryness under reduced pressure.…”

Section: Extracts Preparationmentioning

confidence: 99%

Plumbagin quantification in roots of Plumbago scandens L. obtained by different extraction techniques

Paiva

Lima

Figueiredo

et al. 2004

An. Acad. Bras. Ciênc.

View full text Add to dashboard Cite

The Plumbago genus belongs to the Plumbaginaceae family and it is known due to its variety of biological uses, most of them attributed to the presence of naphthoquinones. Plumbagin is a naturally occurring naphthoquinone that can be obtained from roots of Plumbago scandens L. In order to find out the better technique for plumbagin extraction, were applied: static maceration, dynamic maceration, with assistance of ultrasonic waves and in Soxhlet apparatus. Four compounds were qualitatively detected in all extracts: the naphthoquinones plumbagin and epi-isoshinanolone, palmitic acid and sitosterol. Plumbagin was always the major component in all analyzed extracts and it was quantitatively determined by gas chromatograph coupled with mass spectrometer. Soxhlet was the most efficient extraction technique however, prolonged heating time promoted plumbagin degradation.

show abstract

Section: Extracts Preparationmentioning

confidence: 99%

Plumbagin quantification in roots of Plumbago scandens L. obtained by different extraction techniques

Paiva

Lima

Figueiredo

et al. 2004

An. Acad. Bras. Ciênc.

View full text Add to dashboard Cite

show abstract

“…(9) 131.0 C (10) 134.4 C(10), and from HÀC(8) to C(1), C(6), and C(10), as well as the molecular formula of 4 established the planar structure as 3,4,5-trihydroxy-1-tetralone. A NOESY correlation of HÀC(3) with HÀC(4), together with the smaller coupling constants between HÀC(3) and HÀC(4) (2.9 Hz) suggested a cis relationship for the 3,4-diol moiety [17], implying that its absolute configuration could be assigned using the in situ dimolybdenum CD method developed by Snatzkes method [18] [19]. Upon addition of dimolybdenum tetraacetate [Mo 2 (OAc) 4 ] to a solution of 4 in DMSO, a metal complex was generated as an auxiliary chromophore.…”

mentioning

confidence: 95%

Terpenoid and Phenolic Metabolites from the Fungus Xylaria sp. Associated with Termite Nests

Yan

et al. 2011

Chemistry & Biodiversity

View full text Add to dashboard Cite

Three new sesquiterpene acids, xylaric acids A-C (1-3, resp.), and a new tetralone (=3,4-dihydronaphthalen-1(2H)-one) derivative, 4, along with nine known compounds, xylaric acid D (5), hydroheptelidic acid (6), gliocladic acid (7), chlorine heptelidic acid (8), trichoderonic acid A (9), 16-(α-D-mannopyranosyloxy)isopimar-7-en-19-oic acid (10), 16-(α-D-glucopyranosyloxy)isopimar-7-en-19-oic acid (11), 5-carboxymellein (12), and naphthalen-1,8-diol 1-O-α-D-glucopyranoside (13) have been isolated from the solid culture of the ascomycete fungus Xylaria sp. associated with termite nest. The structures of these compounds were elucidated primarily by NMR experiments. The absolute configurations of compounds 1-3 and 5-9 were determined by combination of X-ray data and CD spectral analysis. The absolute configuration of 4 was assigned by Snatzke's method. Compounds 8 and 11 showed slight cytotoxicities against two cell lines A549 and SGC7901.

show abstract

“…Naphthoquinones are biologically active naturally occurring compounds found in various plant families, including Avicenniaceae, 7) Acanthaceae, [8][9][10][11] Balsaminaceae, Bignoniaceae, 12,13) Boraginaceae, 14) Droseraceae, 15,16) Ebenaceae, 17,18) Juglandaceae, 19) Lythraceae, Nepenthaceae 20) and Plumbagnaceae. 21,22) The common naphthoquinones found in these plant families are shown in Figs.…”

Section: Naphthoquinones Containing Plants In Thailandmentioning

confidence: 99%

Antidiabetic Naphthoquinones and Their Plant Resources in Thailand

Shah

Keach²,

Panichayupakaranant

2018

Chem. Pharm. Bull.

View full text Add to dashboard Cite

Diabetes mellitus is the seventh leading cause of death globally. Ninety percent of the diabetic population suffers from type-2 diabetes, which still needs an effective, safe and economical oral hypoglycemic therapy. Plants are rich sources of various therapeutic molecules. More than 400 medicinal plants of interesting phytochemical diversity have been reported for their antidiabetic potential. Naphthoquinones are a group of phytochemicals, which have a wide range of pharmacological potential, including antidiabetic activity. Naphthoquinones exert their antidiabetic effects through various mechanisms such as the inhibition of α-glucosidase and protein tyrosine phosphatase 1B, increased glucose uptake in myocytes and adipocytes via glucose transporter type 4 (GLUT4) and GLUT2 translocations, enhanced peroxisome proliferator-activated receptor gamma (PPARγ) ligand activity, and by normalizing carbohydrate metabolizing enzymes in the liver. Moreover, naphthoquinone inhibits adipogenesis by both upstream and downstream regulation to control obesity, which is one of the important risk factors for diabetes. Naturally occurring naphthoquinones, as well as their plant sources, are therefore of interest for exploring their antidiabetic potential. The present review aims to overview the antidiabetic potential of naphthoquinones and their plant resources in Thailand.

show abstract

Naphthoquinones and triterpenes from african Diospyros species

Cited by 70 publications

References 14 publications

Plumbagin quantification in roots of Plumbago scandens L. obtained by different extraction techniques

Plumbagin quantification in roots of Plumbago scandens L. obtained by different extraction techniques

Terpenoid and Phenolic Metabolites from the Fungus Xylaria sp. Associated with Termite Nests

Antidiabetic Naphthoquinones and Their Plant Resources in Thailand

Contact Info

Product

Resources

About