Naphthoquinone spiroketal with allelochemical activity from the newly discovered endophytic fungus Edenia gomezpompae

Macías-Rubalcava, Martha Lydia; Hernández‐Bautista, Blanca E.; Manuel, José; González, Martha Letícia Gaeta; Glenn, Anthony E.; Hanlin, Richard T.; Hernández‐Ortega, Simón; Saucedo-García, Aurora; Muria-González, Jordi M.; Anaya, Ana Luisa

doi:10.1016/j.phytochem.2007.12.006

Cited by 98 publications

(88 citation statements)

References 39 publications

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“…Since then, several new spirobisnaphthalene natural products have been isolated and the total syntheses of some of these have been accomplished by different research groups. In addition, many non-natural derivatives have been prepared by synthesis and evaluated for their biological activities [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. The spirobisnaphthalenes isolated from fungi along with their biological activities were further reviewed in 2010 [19,20].…”

Section: Introductionmentioning

confidence: 99%

Total Synthesis and Antifungal Activity of Palmarumycin CP17 and Its Methoxy Analogues

et al. 2016

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Total synthesis of naturally occurring spirobisnaphthalene palmarumycin CP 17 and its methoxy analogues was first achieved through Friedel-Crafts acylation, Wolff-Kishner reduction, intramolecular cyclization, ketalization, benzylic oxidation, and demethylation using the inexpensive and readily available methoxybenzene, 1,2-dimethoxybenzene and 1,4-dimethoxybenzene and 1,8-dihydroxynaphthalene as raw materials. Demethylation with (CH 3 ) 3 SiI at ambient temperature resulted in ring A aromatization and acetal cleavage to give rise to binaphthyl ethers. The antifungal activities of these spirobisnaphthalene derivatives were evaluated, and the results revealed that 5 and 9b exhibit EC 50 values of 9.34 µg/mL and 12.35 µg/mL, respectively, against P. piricola.

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Section: Introductionmentioning

confidence: 99%

Total Synthesis and Antifungal Activity of Palmarumycin CP17 and Its Methoxy Analogues

et al. 2016

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“…Tables 3 and 4. Efficacy of antimicrobial agent is indicated by minimum inhibitory concentrations (MIC) (Tuntiwachwuttikul et al, 2008) or 50% inhibitory concentrations (IC 50 ) value (Macias-Rubalcava et al, 2008). The results indicated variability in the inhibitory concentrations of each extract for the various bacteria.…”

Section: Bajopas Volume 10 Number 1 June 2017mentioning

confidence: 99%

Antibacterial activity and screening for phytochemical components from <i>Borreria stachydea</i> [(DC) Hutch. & Dalziel]

Jacob¹,

Onoja²,

Haruna³

2017

Bayero J. Pure App. Sci.

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The aim of this present study was to determine the phytochemicals and antibacterial activity of Borreria stachydea whole plant using chloroform and methanol as the extracting solvents. The powdered sample was subjected into soxhlet extraction by hot continuous percolation. The extracts were concentrated at 40 o C by vacuum evaporation and later exposed to air d dried crude extracts. Phytochemical screening of the extracts was performed using standard procedures available in literature. Antibacterial activity of B. stachydea was determined using agar well diffusion method, while the Minimal Inhibitor Bactericidal Concentration (MBC) of the extracts against bacteria were determined by broth dilution technique. Phytochemical screening of the extracts revealed the presence of tannins, flavonoids, carbohydrates, cardiac glycosides, terpenes and steroids. Both extracts were active against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis. Comparatively, methanolic extract contained more phytochemicals but lower values of zones of inhibition than chloroform extract. At a concentration of 10 mg/ml, both methanolic extract and sparfloxacin (a standard antibiotic) used as control in this study exhibited similar antibacterial activity against Bacillus subtilis. The results Borreria stachydea contains phytochemicals that are potential sources of antibacterial agents.

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“…The endophyte inoculum was placed on the medium 3 days before the antagonism bioassay. The plant pathogens utilized were: the oomycetes Pythium aphanidermatum, Pythium ultimum, Pythium polytylum, Phytophthora capsici, Phytophthora palmivora, Phytophthora cinnamomi, and Phytophthora parasitica, in addition to the fungi Fusarium oxysporum and Alternaria solani [30]. The microorganisms were incubated at 28°C in 12:12 h light-dark photoperiod and the outcome of the interactions was determined after 22 days.…”

Section: Simple Direct Antagonism Bioassays With Plant Pathogenic Oommentioning

confidence: 99%

Antifungal Volatile Organic Compounds from the Endophyte Nodulisporium sp. Strain GS4d2II1a: a Qualitative Change in the Intraspecific and Interspecific Interactions with Pythium aphanidermatum

Sánchez-Fernández

Díaz²,

Duarte³

et al. 2015

Microb Ecol

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This study demonstrates volatile organic compounds (VOCs) production as one of the defense mechanisms of the antagonistic endophyte Nodulisporium sp. GS4d2II1a, and the volatile changes in two times of the fungal growth; and, as result of its intra and interspecific interactions with the plant pathogen Pythium aphanidermatum. The antifungal activity of the volatile and diffusible metabolites was evaluated by means of three types of antagonism bioassays and by organic extract agar dilution. VOCs were obtained by gas chromatography coupled to mass spectrometry from 3- and 5-day Nodulisporium sp. cultures, as well as from its interspecific in vitro antagonistic interaction with the oomycete P. aphanidermatum, and its intraspecific Nodulisporium sp.-Nodulisporium sp. interaction. The GS4d2II1a strain completely inhibited the growth of two fungi and seven oomycetes by replacing their mycelia in simple antagonism bioassays and by producing in vitro volatile and diffusible metabolites that acted synergistically in multiple antagonism bioassays. Additionally, VOCs inhibited the growth of three oomycetes and one fungus in antagonism bioassays using divided plates. A total of 70 VOCs were detected, mainly including mono and sesquiterpenes, especially eucalyptol and limonene. Multiple correspondence analysis revealed four different volatile profiles, showing that volatiles changed with the fungus age and its intra and interspecific interactions. The metabolites produced by Nodulisporium sp. GS4d2II1a could be useful for biological control of fungal and oomycetes plant pathogens of economically important crops.

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Naphthoquinone spiroketal with allelochemical activity from the newly discovered endophytic fungus Edenia gomezpompae

Cited by 98 publications

References 39 publications

Total Synthesis and Antifungal Activity of Palmarumycin CP17 and Its Methoxy Analogues

Total Synthesis and Antifungal Activity of Palmarumycin CP17 and Its Methoxy Analogues

Antibacterial activity and screening for phytochemical components from <i>Borreria stachydea</i> [(DC) Hutch. & Dalziel]

Antifungal Volatile Organic Compounds from the Endophyte Nodulisporium sp. Strain GS4d2II1a: a Qualitative Change in the Intraspecific and Interspecific Interactions with Pythium aphanidermatum

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