Naphthoquinone Derivative ZSW-4B Induces Apoptosis in Triple-negative Breast Cancer via AMPK signal Activation
Xiyuan Hu,
Hongdou Liu,
Tiao Luo
et al.
Abstract:Triple-negative breast cancer (TNBC) is the most malignant molecular subtype of breast cancer characterized by its strong aggressiveness, high mortality, significant heterogeneity, and poor prognosis. AMPK plays a critical role in maintain cellular energy balance, and its inactivation is associated with the malignancy breast cancer. Here, we identified the pharmacological mechanism of the 1, 4-naphthoquinone derivative ZSW-4B. The MTT assay, colony formation as-say, and nude mouse xenograft tumor model demonst… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.