NaoXinTong Capsule ameliorates memory deficit in APP/PS1 mice by regulating inflammatory cytokines

Wang, Xuerui; Yin, Zequn; Cao, Peichang; Zheng, Shihong; Chen, Yuanli; Yu, Maoyun; Liao, Chenzhong; Zhang, Zhongyuan; Duan, Yajun; Han, Jihong; Zhang, Shuang; Yang, Xiaoxiao

doi:10.1016/j.biopha.2020.110964

Cited by 13 publications

(4 citation statements)

References 38 publications

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“…However, the roles of Rpl18, Eif3c, Rhoc, Gng13, and Gng10 in IS have not been reported. Studies have shown that BYHW, NXT, and YYTN inhibit the inflammatory factors [ 52 , 53 ]. Any of the factors discussed above may be relevant.…”

Section: Discussionmentioning

confidence: 99%

Experimental Evidence of Buyang Huanwu Decoction and Related Modern Preparations (Naoxintong Capsule and Yangyin Tongnao Granule) in Treating Cerebral Ischemia: Intestinal Microorganisms and Transcriptomics in Rats

Yin

Yang

Zhao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. The traditional Chinese medicines of Buyang Huanwu decoction (BYHW), Naoxintong capsule (NXT), and Yangyin Tongnao granules (YYTN) have excellent effects in preventing and treating cerebrovascular disease and are widely tolerated by patients. However, their effects on middle cerebral artery occlusion (MCAO) remain unknown. Methods. We evaluated gut microbiota alterations, the brain transcriptome, and nerve cell responses in rats with MCAO. Results. Our results showed that BYHW, NXT, and YYTN not only effectively improved the damaged state of blood vessels in rats and restored nerve function, but also improved survival. Additional experiments showed that treatment with BYHW, NXT, and YYTN regulated the intestinal microflora. Transcriptome analyses showed that BYHW, NXT, and YYTN modulated the transcriptome of rats with MCAO. The common mechanism of the three prescriptions for the treatment of cerebral ischemia may be related to the intestinal flora regulation of 60S ribosomal protein L18 (Rpl18), eukaryotic translation initiation factor 3 subunit, Ras homolog family member C, G protein subunit gamma 13 (Gng13), and Gng10 genes, among which Rpl18 is the most important. In addition, the three prescriptions had great specificity as anticerebral ischemia targets. Moreover, BYHW, NXT, and YYTN mitigated MCAO-induced hyperactivation of microglia and astrocytes. Conclusion. This study provides a foundation for further research on the mechanisms and treatment of IS. The results strongly suggest that key gut microbiota can be used to study functional genomics of brain, leading to novel discoveries about key genes involved in important biological processes.

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Section: Discussionmentioning

confidence: 99%

Experimental Evidence of Buyang Huanwu Decoction and Related Modern Preparations (Naoxintong Capsule and Yangyin Tongnao Granule) in Treating Cerebral Ischemia: Intestinal Microorganisms and Transcriptomics in Rats

Yin

Yang

Zhao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…APP/PS1 double transgenic mice mimic progressive cognitive deficits and neuropathological changes in humans, which are dependable, easy to operate, and commonly used in AD studies. Higher p-Tau levels and A β aggregation in APP/PS1 mouse brains were related to increased IL-1 β , IL-6, TNF- α , NF- κ B, and TLR4[ 62 ]. Likewise, TLR4 levels and IL-1 β gene expression were significantly increased in hippocampal differentiated mice models without amyloidosis (i.e., entorhinal cortex damaged mice) compared with pseudodamaged mice [ 61 ].…”

Section: Evidence For the Involvement Of Tlr4 In Admentioning

confidence: 99%

Toll-Like Receptor 4: A Promising Therapeutic Target for Alzheimer’s Disease

Xia

et al. 2022

Mediators of Inflammation

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Alzheimer’s disease (AD) is a progressive neurodegenerative disease that primarily manifests as memory deficits and cognitive impairment and has created health challenges for patients and society. In AD, amyloid β-protein (Aβ) induces Toll-like receptor 4 (TLR4) activation in microglia. Activation of TLR4 induces downstream signaling pathways and promotes the generation of proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β), which also trigger the activation of astrocytes and influence amyloid-dependent neuronal death. Therefore, TLR4 may be an important molecular target for treating AD by regulating neuroinflammation. Moreover, TLR4 regulates apoptosis, autophagy, and gut microbiota and is closely related to AD. This article reviews the role of TLR4 in the pathogenesis of AD and a range of potential therapies targeting TLR4 for AD. Elucidating the regulatory mechanism of TLR4 in AD may provide valuable clues for developing new therapeutic strategies for AD.

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“…As a result, NXTC attenuated spatial memory deficit and cognitive decline. In HT-22 cells, it has been shown to block L-glutamic acid-induced production of reactive oxygen species (ROS) ( Wang et al, 2021b ).…”

Section: Clinical Use Of Astragali Radix For Alzhe...mentioning

confidence: 99%

Astragalus mongholicus Bunge (Fabaceae): Bioactive Compounds and Potential Therapeutic Mechanisms Against Alzheimer’s Disease

Dong

Zhang

et al. 2022

Front. Pharmacol.

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Astragalus mongholicus Bunge (Fabaceae) (also known as Astragali radix-AR), a widely used herb by Traditional Chinese Medicine practitioners, possesses a wide range of pharmacological effects, and has been used to treat Alzheimer’s disease (AD) historically. Its bioactive compounds are categorized into four families: saponins, flavonoids, polysaccharides, and others. AR’s bioactive compounds are effective in managing AD through a variety of mechanisms, including inhibiting Aβ production, aggregation and tau hyperphosphorylation, protecting neurons against oxidative stress, neuroinflammation and apoptosis, promoting neural stem cell proliferation and differentiation and ameliorating mitochondrial dysfunction. This review aims to shed light upon the chemical constituents of AR and the mechanisms underlying the therapeutic effect of each compound in manging AD. Also presented are clinical studies which reported successful management of AD with AR and other herbs. These will be helpful for drug development and clinical application of AR to treat AD.

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NaoXinTong Capsule ameliorates memory deficit in APP/PS1 mice by regulating inflammatory cytokines

Cited by 13 publications

References 38 publications

Experimental Evidence of Buyang Huanwu Decoction and Related Modern Preparations (Naoxintong Capsule and Yangyin Tongnao Granule) in Treating Cerebral Ischemia: Intestinal Microorganisms and Transcriptomics in Rats

Experimental Evidence of Buyang Huanwu Decoction and Related Modern Preparations (Naoxintong Capsule and Yangyin Tongnao Granule) in Treating Cerebral Ischemia: Intestinal Microorganisms and Transcriptomics in Rats

Toll-Like Receptor 4: A Promising Therapeutic Target for Alzheimer’s Disease

Astragalus mongholicus Bunge (Fabaceae): Bioactive Compounds and Potential Therapeutic Mechanisms Against Alzheimer’s Disease

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