NaOH-promoted one-pot aryl isothiocyanate synthesis under mild benchtop conditions

Liu, Xinyun; Li, Hang; Yin, Xinbao

doi:10.1080/10426507.2021.1927031

Cited by 6 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Numerous methods using CS 2 have been reported to overcome these limitations. 55–75 Several methods have been explored to broaden the substrate scope of electron-deficient anilines and aminopyridines. 55,57–61,67,71,72,74,75 Moreover, employing a strong base, 69 ball milling, 56 a photoredox catalyst, 72 an electrolytic reaction, 73 or an appropriate desulfurization reagent 60,61,68,71 enables the one-step synthesis of isothiocyanates.…”

Section: Synthesis Of Isothiocyanates With Primary Amines (Type A)mentioning

confidence: 99%

“…55–75 Several methods have been explored to broaden the substrate scope of electron-deficient anilines and aminopyridines. 55,57–61,67,71,72,74,75 Moreover, employing a strong base, 69 ball milling, 56 a photoredox catalyst, 72 an electrolytic reaction, 73 or an appropriate desulfurization reagent 60,61,68,71 enables the one-step synthesis of isothiocyanates. Table 1 provides a comprehensive review of the progress in dithiocarbamate salt protocols over the past decade.…”

Section: Synthesis Of Isothiocyanates With Primary Amines (Type A)mentioning

confidence: 99%

See 1 more Smart Citation

Recent advancement in the synthesis of isothiocyanates

Maeda,

Murakami

2024

Chem. Commun.

View full text Add to dashboard Cite

show abstract

Section: Synthesis Of Isothiocyanates With Primary Amines (Type A)mentioning

confidence: 99%

Section: Synthesis Of Isothiocyanates With Primary Amines (Type A)mentioning

confidence: 99%

Recent advancement in the synthesis of isothiocyanates

Maeda,

Murakami

2024

Chem. Commun.

View full text Add to dashboard Cite

show abstract

“…Several methods have been explored to broaden the substrate scope of electron-deficient anilines and aminopyridines. [55,[57][58][59][60][61]67,71,72,74,75] Moreover, employing a strong base [69] , ball milling [56] , a photoredox catalyst [72] , an electrolytic reaction [73] , or an appropriate desulfurylating reagent [60,61,68,71] enables the one-step synthesis of isothiocyanates.…”

Section: -2 Synthesis Of Isothiocyanates Via Dithiocarbamate Saltmentioning

confidence: 99%

Recent Advancement in Synthesis of Isothiocyanates

Maeda,

Murakami

2023

Preprint

View full text Add to dashboard Cite

Isothiocyanates exhibit various biological characteristics, including antimicrobial, anti-inflammatory, and anticancer properties. Their significance extends to synthetic chemistry, where they serve as valuable platforms for versatile transformations. Consequently, they have attracted the attention of biologists and chemists. This review summarizes recent advancements in the synthesis of isothiocyanates. Access to a variety of starting materials is important to prepare isothiocyanates with diverse structures. This review categorizes synthetic methods into three types based on the starting materials and functional groups: (i) Type A, derived from primary amines; (ii) Type B, derived from other nitrogen functional groups; and (iii) Type C, derived from non-nitrogen groups. Recent trends in synthetic methods have revealed the prevalence of type-A reactions derived from primary amines. However, Type B reactions have rarely been reported. Notably, over the past four years, there has been a notable increase in Type C reactions, indicating a growing interest in non-nitrogen-derived isothiocyanates. Overall, this review not only outlines the advancements in the synthesis of isothiocyanates but also highlights trends in the methodology.

show abstract

Metal‐Free Synthesis of 2‐Aminobenzothiazoles via I₂‐Catalyzed Tandem Cyclization Reaction of Amines and Carbon Disulfide

Chen,

Feng,

Yang

et al. 2024

Chin. J. Chem.

View full text Add to dashboard Cite

Comprehensive SummaryA convenient approach for the construction of 2‐aminobenzothiazoles via I2‐catalyzed tandem cyclization reaction of amines and carbon disulfide has been developed. The present approach starts from simple and readily available starting materials, affording a series of 2‐aminobenzothiazoles in up to 89% yields under metal‐free conditions. In this work, C—H/N—H functionalization was achieved and multiple C‐hetero bonds were successfully constructed in one pot.

show abstract

NaOH-promoted one-pot aryl isothiocyanate synthesis under mild benchtop conditions

Cited by 6 publications

References 27 publications

Recent advancement in the synthesis of isothiocyanates

Recent advancement in the synthesis of isothiocyanates

Recent Advancement in Synthesis of Isothiocyanates

Metal‐Free Synthesis of 2‐Aminobenzothiazoles via I₂‐Catalyzed Tandem Cyclization Reaction of Amines and Carbon Disulfide

Contact Info

Product

Resources

About

NaOH-promoted one-pot aryl isothiocyanate synthesis under mild benchtop conditions

Cited by 6 publications

References 27 publications

Recent advancement in the synthesis of isothiocyanates

Recent advancement in the synthesis of isothiocyanates

Recent Advancement in Synthesis of Isothiocyanates

Metal‐Free Synthesis of 2‐Aminobenzothiazoles via I2‐Catalyzed Tandem Cyclization Reaction of Amines and Carbon Disulfide

Contact Info

Product

Resources

About

Metal‐Free Synthesis of 2‐Aminobenzothiazoles via I₂‐Catalyzed Tandem Cyclization Reaction of Amines and Carbon Disulfide