NaOH/PEG-400: An eloquent system for the synthesis of new thienyl benzo[b]1,4-diazepines

Mandawad, Gajanan G.; Shaikh, Baseer M.; Chobe, Santosh S.; Konda, Shankaraiah G.

doi:10.5155/eurjchem.11.4.276-279.2009

Eur. J. Chem.

2020

DOI: 10.5155/eurjchem.11.4.276-279.2009

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NaOH/PEG-400: An eloquent system for the synthesis of new thienyl benzo[b]1,4-diazepines

Gajanan G. Mandawad¹,

Baseer M. Shaikh

²

,

Santosh S. Chobe³

et al.

Abstract: A simple and eloquent procedure for the synthesis of a new series of thienyl benzo[b]1,4-diazepines is reported. They were synthesized by the condensation of o-phenylenediamine (o-PDA) with distinct hetero chalcones using NaOH in polyethylene glycol (PEG-400) as green and alternative reaction solvent. The significances of this present method are shorter reaction time, easy work-up, high yields, and mild reaction conditions. Furthermore, this method is environment friendly and without use of an expensive cataly… Show more

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Cited by 3 publications

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“… 101 From the past few decades, the synthesis of 1,4-BZDs gained tremendous attention due to their multiple use in the medical field. 102 In this literature review, several current synthetic approaches of 1,4-BZD derivatives using OPD as one of the reactants are given with their advantages and drawbacks.…”

Section: Synthetic Approaches Of Bzdsmentioning

confidence: 99%

Synthetic aspects of 1,4- and 1,5-benzodiazepines using o -phenylenediamine: a study of past quinquennial

Teli¹,

Teli²,

Soni³

et al. 2023

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“… 101 From the past few decades, the synthesis of 1,4-BZDs gained tremendous attention due to their multiple use in the medical field. 102 In this literature review, several current synthetic approaches of 1,4-BZD derivatives using OPD as one of the reactants are given with their advantages and drawbacks.…”

Section: Synthetic Approaches Of Bzdsmentioning

confidence: 99%

Synthetic aspects of 1,4- and 1,5-benzodiazepines using o -phenylenediamine: a study of past quinquennial

Teli¹,

Teli²,

Soni³

et al. 2023

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

Polyethylene Glycol-400 Prompted an Efficient Synthesis of Thienyl Pyrazolo[ 1,5‐a] Pyrimidines as Microbial Inhibitors

Konda

¹

,

Mandawad²,

Chobe³

et al. 2022

COS

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

An efficient method for the synthesis of N-(4-halophenacyl)-2-substituted-benzo[d]imidazoles using PEG-400 as green reaction solvent

Konda

¹

,

Jore

²

,

Jeughale

³

et al. 2026

Eur. J. Chem.

0

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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