Nanozymes in Tumor Theranostics

Ma, Qiulian; Liu, Yanfang; Zhu, Haitao; Zhang, Lirong; Liao, Xiang

doi:10.3389/fonc.2021.666017

Cited by 23 publications

(14 citation statements)

References 114 publications

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“…ROS scavenging nanozymes are known to synergistically enhance the avenues of anti-tumor therapy such as chemotherapy (CT), photodynamic therapy (PDT), photothermal therapy (PTT), radiotherapy (RT), and sonodynamic therapy (SDT). These therapies depend upon the oxygen level and sensitizers mainly singlet O 2 to generate ROS [ 1 , 7 , 11 ]. Afrasiabi et al,evaluated super paramagnetic iron oxide nanoparticles (SPIONs) effects on oral squamous cell carcinoma (OSCC) mitochondria.…”

Section: Nanozymes In Oral Cancermentioning

confidence: 99%

“…Modification of nanozymes with folic acid can effectively target the cell surface of cancerous cells with folic acid receptors and promote cell death as oxidants. In addition, Pt nanoparticles/graphene oxide with folic acid aid in distinguishing many cancerous cells more precisely than naked-eye [ 1 ]. Essawy et al, utilised Au nanoparticles to determine their simultaneous role as both carriers and therapeutic agents in oral cancer.…”

Section: Nanozymes In Oral Cancermentioning

confidence: 99%

“…With these enormous advantages nanozymes are immensely advanced in various fields including tumor biology. Nanoparticles including magnetic, cerium oxide, gold and many more have displayed intrinsic catalytic activities and find application for cancer diagnosis, therapeutics and theranostics [ 1 ]. This review emphasises the potential applications of nanozymes in oral cancer.…”

Section: Introductionmentioning

confidence: 99%

“…Apart from well-known causative agents like betel nut and tobacco association with bacterial, human papilloma virus (HPV) infection, genetic alterations are also attributed in oral oncogenesis. Therapeutic resistance, recurrence, and metastasis are the major consequences of these interplays and causative agents [1][2][3]. Hence it is crucial to probe into novel therapeutic designs to enhance sensitivity of cancer management.…”

Section: Introductionmentioning

confidence: 99%

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Role of Nanozymes in Oral Cancer the Road Ahead

et al. 2022

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Oral cancer is a result of diverse interactions in the tumor microenvironment (TME), genetic alterations along with associated risk factors such as lifestyle and microbial infections. Various modalities are employed in the diagnosis and therapeutics of oral cancer. Nanozymes which are artificial enzymes have a great potential in the diagnostic and therapeutic approach of tumors. They have enormous advantages compared to natural enzymes and possess inherent biological and physical properties. A web-based search was performed via the Google scholar, PubMed database, Web of Science with keywords nanozymes, nanoparticles in cancer and oral cancer. The other keywords used were diagnosis, therapy, TME, microbiome, molecular alterations, biosensor, targeted therapy, imaging and tissue regeneration. Original research studies, reviews, case reports published from 2012 to 2022 were included to appraise different subsections. An absolute lack of literature on nanozymes was observed in oral cancer. The present review is the first attempt to describe the role and application of nanozymes in oral cancer by correlating its outcome in tumor biology and biomedical research. Rapid development of nanotechnology has created a paradigm shift in cancer diagnosis and therapeutics. Nanozymes with novel designs can be anticipated in the future in oral cancer management. Supplementary Information The online version contains supplementary material available at 10.1007/s11244-022-01729-9.

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Section: Nanozymes In Oral Cancermentioning

confidence: 99%

Section: Nanozymes In Oral Cancermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Role of Nanozymes in Oral Cancer the Road Ahead

et al. 2022

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“…Indeed, multimodal nanoparticles with intrinsic and/or added functionalities, along with enzymatic action, have emerged as key candidates for numerous attractive biomedical functions. Several authors have reviewed the development of general or specific aspects of nanozyme applications in diagnostics and medicine [ 13 , 14 , 15 ]. Some key enzymes or classes of enzymes, such as superoxide dismutase (SOD), catalase (CAT), oxidase (OXD), peroxidase (POD), deoxyribonuclease (DNase), etc., have been implicated in both antibacterial and anticancer therapy.…”

Section: Introductionmentioning

confidence: 99%

Emerging Prospects of Nanozymes for Antibacterial and Anticancer Applications

et al. 2022

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The ability of some nanoparticles to mimic the activity of certain enzymes paves the way for several attractive biomedical applications which bolster the already impressive arsenal of nanomaterials to combat deadly diseases. A key feature of such ‘nanozymes’ is the duplication of activities of enzymes or classes of enzymes, such as catalase, superoxide dismutase, oxidase, and peroxidase which are known to modulate the oxidative balance of treated cells for facilitating a particular biological process such as cellular apoptosis. Several nanoparticles that include those of metals, metal oxides/sulfides, metal–organic frameworks, carbon-based materials, etc., have shown the ability to behave as one or more of such enzymes. As compared to natural enzymes, these artificial nanozymes are safer, less expensive, and more stable. Moreover, their catalytic activity can be tuned by changing their size, shape, surface properties, etc. In addition, they can also be engineered to demonstrate additional features, such as photoactivated hyperthermia, or be loaded with active agents for multimodal action. Several researchers have explored the nanozyme-mediated oxidative modulation for therapeutic purposes, often in combination with other diagnostic and/or therapeutic modalities, using a single probe. It has been observed that such synergistic action can effectively by-pass the various defense mechanisms adapted by rogue cells such as hypoxia, evasion of immuno-recognition, drug-rejection, etc. The emerging prospects of using several such nanoparticle platforms for the treatment of bacterial infections/diseases and cancer, along with various related challenges and opportunities, are discussed in this review.

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Machine‐Learning‐Assisted Nanozyme Design: Lessons from Materials and Engineered Enzymes

et al. 2023

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Nanozymes are nanomaterials that exhibit enzyme‐like biomimicry. In combination with intrinsic characteristics of nanomaterials, nanozymes have broad applicability in materials science, chemical engineering, bioengineering, biochemistry, and disease theranostics. Recently, the heterogeneity of published results has highlighted the complexity and diversity of nanozymes in terms of consistency of catalytic capacity. Machine learning (ML) shows promising potential for discovering new materials, yet it remains challenging for the design of new nanozymes based on ML approaches. Alternatively, ML is employed to promote optimization of intelligent design and application of catalytic materials and engineered enzymes. Incorporation of the successful ML algorithms used in the intelligent design of catalytic materials and engineered enzymes can concomitantly facilitate the guided development of next‐generation nanozymes with desirable properties. Here, recent progress in ML, its utilization in the design of catalytic materials and enzymes, and how emergent ML applications serve as promising strategies to circumvent challenges associated with time‐expensive and laborious testing in nanozyme research and development are summarized. The potential applications of successful examples of ML‐aided catalytic materials and engineered enzymes in nanozyme design are also highlighted, with special focus on the unified aims in enhancing design and recapitulation of substrate selectivity and catalytic activity.

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Nanozymes in Tumor Theranostics

Cited by 23 publications

References 114 publications

Role of Nanozymes in Oral Cancer the Road Ahead

Role of Nanozymes in Oral Cancer the Road Ahead

Emerging Prospects of Nanozymes for Antibacterial and Anticancer Applications

Machine‐Learning‐Assisted Nanozyme Design: Lessons from Materials and Engineered Enzymes

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