Nanozyme-Based Bandage with Single-Atom Catalysis for Brain Trauma

Abstract

Neurotrauma is one of the most serious traumatic injuries, which can induce an excess amount of reactive oxygen and nitrogen species (RONS) around the wound, triggering a series of biochemical responses and neuroinflammation. Traditional antioxidant-based bandages can effectively decrease infection via preventing oxidative stress, but its effectiveness is limited to a short period of time due to the rapid loss of electron-donating ability. Herein, we developed a nanozyme-based bandage using single-atom Pt/CeO2 with a persistent catalytic activity for noninvasive treatment of neurotrauma. Single-atom Pt induced the lattice expansion and preferred distribution on (111) facets of CeO2, enormously increasing the endogenous catalytic activity. Pt/CeO2 showed a 2–10 times higher scavenging activity against RONS as well as 3–10 times higher multienzyme activities compared to CeO2 clusters. The single-atom Pt/CeO2 retained the long-lasting catalytic activity for up to a month without obvious decay due to enhanced electron donation through the Mars–van Krevelen reaction. In vivo studies disclosed that the nanozyme-based bandage at the single-atom level can significantly improve the wound healing of neurotrauma and reduce neuroinflammation.

Antioxidants and Nanotechnology: Promises and Limits of Potentially Disruptive Approaches in the Treatment of Central Nervous System Diseases

“…In vivo studies have demonstrated that nanoceria could be used as a protective agent against several forms of neuronal damage, including cerebral ischemia/reperfusion injury, lead‐induced hippocampal damage, diabetic neurophaty, and cognitive impairments caused by hypoxia . Yan et al developed a nanozyme based on Pt/CeO 2 with efficient catalytic activity for the treatment of neurotrauma, and in vivo studies demonstrated that this material can improve the healing and reduce neuroinflammation . In vivo studies proved that nanoceria might be further exploited in the treatment of autoimmune diseases like multiple sclerosis and amyotrophic lateral sclerosis.…”

Catalytically potent and selective clusterzymes for modulation of neuroinflammation through single-atom substitutions

“…ue to their exclusive catalytic activity and selectivity, artificial enzymes are exploited as promising tools for wide-reaching biomedical implications [1][2][3][4][5][6][7][8] , particularly as advanced diagnostics 9,10 and therapeutics [11][12][13][14][15][16] of diseases. Earlier studies shed light on the oxidase-and peroxidase-like activities of noble metals 17 .…”

Atomic engineering of single-atom nanozymes for enzyme-like catalysis

“…105 Similar work was reported by Lu et al 106 Besides, Ming and Zhang's groups developed single-atom Pt/CeO 2 based bandage for treatment of brain trauma. 88 The single-atom Pt/CeO 2 showed excellent peroxidase (POD)-, catalase (CAT)-, superoxide dismutase (SOD)-and glutathione peroxidase (GPx)-like activity, much higher than that of CeO 2 clusters (Fig. 9a).…”

“…Although the apparent activities of SAzymes have exceeded those of nanomaterial-based nanozymes, they still far below those of the corresponding natural enzymes. 71,88 Therefore, we should greatly improve the enzyme-like activity of SAzymes through the above two aspects to meet the requirements of practical applications. Since the single-site loading rates of most SAzymes were lower than 1 wt%, there is still room for activity improvements.…”