Nanozyme antioxidants as emerging alternatives for natural antioxidants: Achievements and challenges in perspective

Ghorbani, Mazaher; Derakhshankhah, Hossein; Jafari, Samira; Salatin, Sara; Dehghanian, Mojtaba; Falahati, Mojtaba; Ansari, Ali

doi:10.1016/j.nantod.2019.100775

Cited by 58 publications

(41 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 142c,146 ] In this scenario, the development of reproducible and reliable analytical methods for the dynamic characterization of the evolution of nanomaterials in biological environments is recognized as a pressing need to perform reliable nanosafety studies. This was pointed out, e.g., back in 2012 in an editorial of Nature Nanotechnology , [ 147 ] and more recently, for the specific case of a type of NPs (nanozymes) by the news and opinion of Ghorbani et al [ 24 ]…”

Section: Toxicity and Safety: A Remaining Challengementioning

confidence: 99%

“…Furthermore, CeO 2 NPs have been reported to be prooxidant (instead of anti‐oxidant) depending on its aggregation state, [ 137,152,156 ] and chronic exposure to CeO 2 NPs aggregates was found to be associated with increased levels of ROS and heat shock stress response. [ 152 ] In turn, generally, isolated, noncontaminated NPs consistently show no toxicity and, in the case of NPs, displaying therapeutic benefits, e.g., references in Section 3.4 and references in the reviews of Wang et al, [ 23 ] Liu et al, [ 22 ] and Ghorbani et al [ 24 ]…”

Section: Toxicity and Safety: A Remaining Challengementioning

confidence: 99%

“…Nowadays, a large amount of data regarding NPs activity has been gathered but little progress made toward matching expectations since some key parameters such as their stability in the physiological media (agglomeration or degradation) and protein corona formation, the impact of pH and temperature and biodistribution, clearance and excretion routes have not been properly addressed in most of the papers. [ 24,146 ]…”

Section: Toxicity and Safety: A Remaining Challengementioning

confidence: 99%

“…The recent works of Liu et al [ 22 ] on “antioxidant nanomaterials” and Wang et al [ 23 ] and Ghorbani et al [ 24 ] on “nanozymes” offers a comprehensive review of different types of NPs proposed in the scientific literature. Furthermore, the rationale behind their important role of NPs in nanomedicine, the new developments in this promising therapeutic strategy, and the mechanisms of action of antioxidant nanosystems have been also recently described and reviewed.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Cerium Oxide Nanoparticles: Advances in Biodistribution, Toxicity, and Preclinical Exploration

Casals

Zeng

Parra‐Robert

et al. 2020

Small

100

View full text Add to dashboard Cite

to contribute to improved treatments by the generation of new diagnostic and therapeutic products. In particular, inorganic nanoparticles (NPs) have emerged as flexible platforms to develop new imaging and therapy agents for detecting and treating diseases at its earliest stages, with benefits superior to any currently used treatments. [1] These materials have been reported as robust drug carriers, versatile scaffolds able to adjust conjugated biomolecules activity, and antennas that can be excited in biologically transparent media. [2] Besides, they can be easily detected and tracked in physiological environments due to their unique physicochemical signatures. [3] Thus, nowadays, with the requirements for more personalized treatments and precision medications, [4] the interest in these materials to develop multimodal/multifunctional nanosized particles that can perform diagnosis [5] and different therapies (such as chemo-, thermo-, radio-, immunotherapies) in a single nanoplatform [6] is continuously growing. [7] Among the broad range of newly proposed nanomaterials, antioxidant NPs add to this list of advantages that they even Antioxidant nanoparticles have recently gained tremendous attention for their enormous potential in biomedicine. However, discrepant reports of either medical benefits or toxicity, and lack of reproducibility of many studies, generate uncertainties delaying their effective implementation. Herein, the case of cerium oxide is considered, a well-known catalyst in the petrochemistry industry and one of the first antioxidant nanoparticles proposed for medicine. Like other nanoparticles, it is now described as a promising therapeutic alternative, now as threatening to health. Sources of these discrepancies and how this analysis helps to overcome contradictions found for other nanoparticles are summarized and discussed. For the context of this analysis, what has been reported in the liver is reviewed, where many diseases are related to oxidative stress. Since well-dispersed nanoparticles passively accumulate in liver, it represents a major testing field for the study of new nanomedicines and their clinical translation. Even more, many contradictory works have reported in liver either cerium-oxide-associated toxicity or protection against oxidative stress and inflammation. Based on this, finally, the intention is to propose solutions to design improved nanoparticles that will work more precisely in medicine and safely in society.

show abstract

Section: Toxicity and Safety: A Remaining Challengementioning

confidence: 99%

Section: Toxicity and Safety: A Remaining Challengementioning

confidence: 99%

Section: Toxicity and Safety: A Remaining Challengementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cerium Oxide Nanoparticles: Advances in Biodistribution, Toxicity, and Preclinical Exploration

Casals

Zeng

Parra‐Robert

et al. 2020

Small

100

View full text Add to dashboard Cite

show abstract

“…This means that their biological activity is only carried out in the case of ROS overproduction [ 31 ] and they become a rather inert material in healthy physiological conditions, slowly dissolving into innocuous cerium ions which are finally expulsed via the urinary track or the hepatic route [ 32 , 33 ]. Thus, CeO 2 NPs are considered one of the major players in what has recently been called “nanocatalytic medicine” [ 34 ], or “ROS-based nanomedicine” [ 35 ], understood as the use of nanozymes [ 36 , 37 ] and antioxidant nanomaterials [ 38 ] (and also photocatalysts and electrocatalysts) to initiate catalytic (enzymatic) reactions and modulate biological microenvironments to generate therapeutic effects.…”

Section: Antioxidant Properties Of Ceo 2 Npsmentioning

confidence: 99%

Cerium Oxide Nanoparticles: A New Therapeutic Tool in Liver Diseases

Casals¹,

Perramón²,

Casals

et al. 2021

Antioxidants

View full text Add to dashboard Cite

Oxidative stress induced by the overproduction of free radicals or reactive oxygen species (ROS) has been considered as a key pathogenic mechanism contributing to the initiation and progression of injury in liver diseases. Consequently, during the last few years antioxidant substances, such as superoxide dismutase (SOD), resveratrol, colchicine, eugenol, and vitamins E and C have received increasing interest as potential therapeutic agents in chronic liver diseases. These substances have demonstrated their efficacy in equilibrating hepatic ROS metabolism and thereby improving liver functionality. However, many of these agents have not successfully passed the scrutiny of clinical trials for the prevention and treatment of various diseases, mainly due to their unspecificity and consequent uncontrolled side effects, since a minimal level of ROS is needed for normal functioning. Recently, cerium oxide nanoparticles (CeO2NPs) have emerged as a new powerful antioxidant agent with therapeutic properties in experimental liver disease. CeO2NPs have been reported to act as a ROS and reactive nitrogen species (RNS) scavenger and to have multi-enzyme mimetic activity, including SOD activity (deprotionation of superoxide anion into oxygen and hydrogen peroxide), catalase activity (conversion of hydrogen peroxide into oxygen and water), and peroxidase activity (reducing hydrogen peroxide into hydroxyl radicals). Consequently, the beneficial effects of CeO2NPs treatment have been reported in many different medical fields other than hepatology, including neurology, ophthalmology, cardiology, and oncology. Unlike other antioxidants, CeO2NPs are only active at pathogenic levels of ROS, being inert and innocuous in healthy cells. In the current article, we review the potential of CeO2NPs in several experimental models of liver disease and their safety as a therapeutic agent in humans as well.

show abstract

Biocatalytic and Antioxidant Nanostructures for ROS Scavenging and Biotherapeutics

Wang

Zhu

Deng

et al. 2021

Adv Funct Materials

View full text Add to dashboard Cite

In human systems, reactive oxygen species (ROS) significantly affect different physiological activities and play critical roles in diverse living processes. It is widely known that excessive ROS generation in inflammatory tissues can further deteriorate the localized tissue injury and cause chronic diseases. Though promising for reducing ROS levels, many antioxidant molecules and natural enzymes suffer from abundant intrinsic limitations. Recently, a series of biocatalytic or antioxidant nanostructures have been designed with distinctive ROS scavenging capabilities, which show promising activities to overcome these kernel challenges. In this timely review, the most recent advances in engineering biocatalytic and antioxidant nanostructures for ROS scavenging are summarized. First, the ROS scavenging principles and corresponding methods for testing various enzymatic activities are carefully concluded. Subsequently, the rationally designed nanostructures with high ROS scavenging efficiencies are comprehensively discussed, especially on the catalytic activities, mechanisms, and structure‐function relationships. After that, the representative applications of these ROS scavenging nanostructures for diverse biotherapeutics are summarized in detail. At last, the primary challenges and future perspectives in this emerging research frontier have also been outlined. It is believed that this progress review will offer a cutting‐edge understanding and guidance to engineering future high‐performance ROS scavenging nanostructures for broad biotherapeutic applications.

show abstract

Nanozyme antioxidants as emerging alternatives for natural antioxidants: Achievements and challenges in perspective

Cited by 58 publications

References 33 publications

Cerium Oxide Nanoparticles: Advances in Biodistribution, Toxicity, and Preclinical Exploration

Cerium Oxide Nanoparticles: Advances in Biodistribution, Toxicity, and Preclinical Exploration

Cerium Oxide Nanoparticles: A New Therapeutic Tool in Liver Diseases

Biocatalytic and Antioxidant Nanostructures for ROS Scavenging and Biotherapeutics

Contact Info

Product

Resources

About