Nanozeolite bioconjugates labeled with 223 Ra for targeted alpha therapy

Gold nanoparticle bioconjugates labelled with 211At for targeted alpha therapy

“…33 We have also shown that SP(5-11) has similar affinity to NK1 receptors as the whole peptide (IC 50 ¼ 38 nM). 34 The PEG linker (2000 kDa) comprising the disulde bridge and the N-hydroxysuccinimide esters (NHS) at the ends was used for synthesis of the SP(5-11)-PEG-SS-PEG-SP(5-11) conjugate. The process of nanoparticles biofunctionalization is summarized in Fig.…”

Current Aspects of Radiopharmaceutical Chemistry

“…Some radioligands showed low brain uptake in NHPs, although they had a preferable molecular weight and lipophilicity to cross the BBB by passive transport [107]; therefore, investigation into the background of the poor BBB permeability could help optimize radioligands for HDAC imaging in the brain. Besides the radioligands with binding affinity for multiple HDACs, the development of isoform-specific ligands is also awaited because disease-related changes in HDAC expression may be isoform specific.…”

“…Although current results demonstrate promise for this hybrid ligand, the BFC version must be evaluated before any conclusions can be made regarding its utility in 89 Zr-immuno-PET applications. Taking cues from Guerard et al [98], Patra and coworkers, reported the DFO analog, DFO* (19), which was easily synthesized from the DFO-mesylate salt and the protected hydroxamic acid precursor ( Figure 6) [107]. While derivatization to introduce functional groups for bioconjugation into 19 was facile, preparing and characterizing the Nat Zr-19 complex was challenging due to its poor solubility.…”

Radiolabeled Nanoparticles in Nuclear Oncology

“…These NPs were pegylated and labeled with 223 Ra by ion exchange with the sodium. Results showed efficient targeting of glioma cells and satisfactory retention of the radioisotope in the NPs [122].…”