Nanovesicular Photodynamic Clinical Treatment of Resistant Plantar Warts

Fadel, Maha; Kassab, Kawser; Samy, Nevien; Abdelfadeel, Doaa; Yassin, Ghada E.; Nasr, Maha

doi:10.2174/1567201817666200324142221

Cited by 17 publications

(6 citation statements)

References 37 publications

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“…In this case study, we used transfersomes as it was proved that transfersomes were superior to liposomes in the dermal and transdermal delivery [ 16 ]. The presence of edge activator, as SDC, in their lipid membrane improved the membrane deformability and flexibility, permits the passage of the vesicles between the narrow skin pores, thus delivering the drug to deeper skin layers without being cracked [ 17 ].…”

Section: Resultsmentioning

confidence: 99%

Transfersomal eosin topical delivery assisted by fractional CO2 laser for photodynamic treatment of palmar hyperhidrosis: case study

Fadeel

Fadel

Tawfik

et al. 2022

Drug Deliv. and Transl. Res.

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Hyperhidrosis is a condition in which the cholinergic receptors on the eccrine glands are overstimulated, resulting in excessive sweating. It is considered a serious cosmetic and psychological problem that affects the patient’s quality of life. Searching for novel treatment modalities is required to minimize the side effects and to attain better patient satisfaction.Photodynamic therapy (PDT), using eosin as a photosensitizer, is developed as a promising modality of the treatment of palmar and axillary hyperhidrosis. In this study, we treated six cases suffering palmar hyperhidrosis by applying the fractional CO2 laser prior to PDT session. For PDT, a hydrogel of eosin loaded in a transfersomes as a nano-delivery carrier was applied for 5 min, followed by irradiation by intense pulsed light (IPL). The prepared transfersomes loaded by eosin were spherical in shape with encapsulation efficiency of 33 ± 3.5%, particle size 305.5 ± 5.7 nm, average zeta potential of − 54 ± 7.6 mV with 80 ± 4% of the loaded eosin was released after 3 h. Two cases achieved 90% improvement after four sessions, three patients needed six sessions to show 75% improvement, while one patient showed only 25% improvement after six sessions. This resulted in shortening the time of PS application and decreasing the number of sessions required to achieve acceptable improvement. More clinical studies on large number of patients are required to optimize the results. Graphical abstract

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Section: Resultsmentioning

confidence: 99%

Transfersomal eosin topical delivery assisted by fractional CO2 laser for photodynamic treatment of palmar hyperhidrosis: case study

Fadeel

Fadel

Tawfik

et al. 2022

Drug Deliv. and Transl. Res.

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“…Modifying the delivery vehicle of the photosensitizer may also enhance outcomes; PDT with methylene blue delivered within a transferosome nano-vesicular system had a higher rate of complete resolution of plantar warts relative to free methylene gel (86.67% vs 53.57%) and required a lower number of cycles (2.2 vs 4.14). 109…”

Section: Emerging Indicationsmentioning

confidence: 99%

A Review of the Dermatologic Clinical Applications of Topical Photodynamic Therapy

Luo,

Bose,

Bawazir

et al. 2024

J Cutan Med Surg

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Topical photodynamic therapy is a widely approved therapy for actinic keratoses and low-risk nonmelanoma skin cancers with a rapidly growing range of emerging indications for other cutaneous diseases. This review summarizes the best-available evidence to provide a clinical update for dermatologists on the approved and emerging indications of photodynamic therapy. The body of evidence suggests that photodynamic therapy is superior or noninferior to other available treatment modalities for actinic keratoses, low-risk basal cell carcinomas, Bowen’s disease, skin field cancerization, chemoprevention of keratinocyte carcinomas in organ transplant recipients, photoaging, acne vulgaris, and cutaneous infections including verrucae, onychomycosis, and cutaneous leishmaniasis. There is emerging evidence that photodynamic therapy plays a role in the management of actinic cheilitis, early-stage mycosis fungoides, extramammary Paget disease, lichen sclerosis, and folliculitis decalvans but there are no comparative studies with other active treatment modalities. Common barriers to topical photodynamic therapy include procedural pain, costs, and the time required for treatment delivery. There is significant heterogeneity in the photodynamic therapy protocols reported in the literature, including different photosensitizers, light sources, number of treatments, time between treatments, and use of procedural analgesia. Topical photodynamic therapy should be considered in the management of a spectrum of inflammatory, neoplastic, and infectious dermatoses. However, more comparative research is required to determine its role in the treatment algorithm for these dermatologic conditions and more methodological research is required to optimize photodynamic therapy protocols to improve the tolerability of the procedure for patients.

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“…Plantar warts were treated at the clinical level using MB encapsulated within a nanovesicular form known as transferosome [56]. Transfersomes are highly elastic and deformable version of the liposomes that can easily penetrate through tight pores and thus are well suited for topical applications [57].…”

Section: Reported Clinical Trials Using Nano Ps‐pdtmentioning

confidence: 99%

Nanotechnology and photodynamic therapy from a clinical perspective

Gaber

Fadel

2022

Transl Biophotonics

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Photodynamic therapy (PDT) is currently applied clinically in many medical centers worldwide. The clinical outcomes are from one side satisfying and from the other side highlighting the areas of further development. Issues like hydrophobicity of the photosensitizer (PS), uncontrolled distribution and limited tissue penetration of the accompanying light sources triggered the interest of many research groups. Nanotechnology outstood among the various suggested enhancement solutions. In this review, the rationale behind using nanotechnology is discussed. Light is shed on the status of nanotechnology from approval for clinical use. Clinical studies of PS‐loaded nanoparticles are summarized and the challenges facing the progress of those systems are enumerated.

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Nanovesicular Photodynamic Clinical Treatment of Resistant Plantar Warts

Cited by 17 publications

References 37 publications

Transfersomal eosin topical delivery assisted by fractional CO2 laser for photodynamic treatment of palmar hyperhidrosis: case study

Transfersomal eosin topical delivery assisted by fractional CO2 laser for photodynamic treatment of palmar hyperhidrosis: case study

A Review of the Dermatologic Clinical Applications of Topical Photodynamic Therapy

Nanotechnology and photodynamic therapy from a clinical perspective

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