Nanovehicles for co-delivery of anticancer agents

Zeinali, Mahdi; Abbaspour‐Ravasjani, Soheil; Ghorbani, Marjan; Babazadeh, Afshin; Soltanfam, Tannaz; Santos, Ana Cláudia; Hamishehkar, Hamed; Hamblin, Michael R.

doi:10.1016/j.drudis.2020.06.027

Cited by 81 publications

(43 citation statements)

References 108 publications

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“…By measuring the absorbance of loaded GO spectrophotometrically (Ultrospec 2000, Pharmacia Biotech, UK) at 319 nm, the amount of entrapped GO was determined 49 . Following the EE% and DLC% were calculated using the following equations (1).…”

Section: Rungratanawanich Et Al Investigated the Cellular Antioxidant Activity Of Go And Its Relatedmentioning

confidence: 99%

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Prevention of UV-induced skin cancer in mice by gamma oryzanol-loaded nanoethosomes

et al. 2021

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Section: Rungratanawanich Et Al Investigated the Cellular Antioxidant Activity Of Go And Its Relatedmentioning

confidence: 99%

“…Cancer is one of the serious human health problems globally, and its treatment is always associated with a variety of challenges 1 . Skin is the important and largest organ in the human body 2 which, undergoes the most exposure to the environment, including ultraviolet (UV) radiation from sunlight.…”

Section: Introductionmentioning

confidence: 99%

Prevention of UV-induced skin cancer in mice by gamma oryzanol-loaded nanoethosomes

et al. 2021

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“…Following the rapid progression of nanotechnology, drugs incorporating nanoparticles have been examined to prolong blood circulation time, increase therapeutic tumor accumulation, promote anti-cancer activity, reduce undesirable side effects, and overcome multidrug resistance [ 3 , 4 ]. Several drug delivery systems with multiple mechanistic functions have been reported [ 5 ]. For example, polymers, dendrimers, and lipid-based delivery systems have demonstrated encouraging therapeutic activities in both in vitro and in vivo conditions [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Silencing of HMGA2 by siRNA Loaded Methotrexate Functionalized Polyamidoamine Dendrimer for Human Breast Cancer Cell Therapy

Gaballu

Cho

Dehghan

et al. 2021

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The transcription factor high mobility group protein A2 (HMGA2) plays an important role in the pathogenesis of some cancers including breast cancer. Polyamidoamine dendrimer generation 4 is a kind of highly branched polymeric nanoparticle with surface charge and highest density peripheral groups that allow ligands or therapeutic agents to attach it, thereby facilitating target delivery. Here, methotrexate (MTX)- modified polyamidoamine dendrimer generation 4 (G4) (G4/MTX) was generated to deliver specific small interface RNA (siRNA) for suppressing HMGA2 expression and the consequent effects on folate receptor (FR) expressing human breast cancer cell lines (MCF-7, MDA-MB-231). We observed that HMGA2 siRNA was electrostatically adsorbed on the surface of the G4/MTX nanocarrier for constructing a G4/MTX-siRNA nano-complex which was verified by changing the final particle size and zeta potential. The release of MTX and siRNA from synthesized nanocomplexes was found in a time- and pH-dependent manner. We know that MTX targets FR. Interestingly, G4/MTX-siRNA demonstrates significant cellular internalization and gene silencing efficacy when compared to the control. Besides, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay demonstrated selective cell cytotoxicity depending on the folate receptor expressing in a dose-dependent manner. The gene silencing and protein downregulation of HMGA2 by G4/MTX-siRNA was observed and could significantly induce cell apoptosis in MCF-7 and MDA-MB-231 cancer cells compared to the control group. Based on the findings, we suggest that the newly developed G4/MTX-siRNA nano-complex may be a promising strategy to increase apoptosis induction through HMGA2 suppression as a therapeutic target in human breast cancer.

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“…Encouragingly, recent studies have depicted nanotechnology in the improvement of drug efficacy against amoebae (Anwar et al 2019a, b, c, d;Mungroo et al 2020;Rajendran et al 2019;Walvekar et al 2020). Moreover, nanovehicles have high loading capacity, enhanced permeability, and the possibility to encompass several agents within one carrier, which have retention effects that are useful in active and passive targeting of parasites (Zeinali et al 2020). Indeed, one of the advantages of using nanovehicles is that the system can encompass more than one agent; thus, there is the possibility of synergistic effects being induced (Zeinali et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Nanovehicles in the improved treatment of infections due to brain-eating amoebae

et al. 2021

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Pathogenic free-living amoebae are known to cause fatal central nervous system infections with extremely high mortality rates. High selectivity of the blood-brain barrier hampers delivery of drugs and untargeted delivery of drugs can cause severe side effects. Nanovehicles can be used for targeted drug delivery across the blood-brain barrier. Inorganic nanoparticles have been explored as carriers for various biomedical applications and can be modified with various ligands for efficient targeting and cell selectivity while lipid-based nanoparticles have been extensively used in the development of both precision and colloidal nanovehicles. Nanomicelles and polymeric nanoparticles can also serve as nanocarriers and may be modified so that responsiveness of the nanoparticles and release of the loads are linked to specific stimuli. These nanoparticles are discussed here in the context of the treatment of central nervous system infections due to pathogenic amoebae. It is anticipated that these novel strategies can be utilized in tandem with novel drug leads currently in the pipeline and yield in the development of much needed treatments against these devastating parasites.

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Nanovehicles for co-delivery of anticancer agents

Cited by 81 publications

References 108 publications

Prevention of UV-induced skin cancer in mice by gamma oryzanol-loaded nanoethosomes

Prevention of UV-induced skin cancer in mice by gamma oryzanol-loaded nanoethosomes

Silencing of HMGA2 by siRNA Loaded Methotrexate Functionalized Polyamidoamine Dendrimer for Human Breast Cancer Cell Therapy

Nanovehicles in the improved treatment of infections due to brain-eating amoebae

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