Nanotube-formed Ti substrates coated with silicate/silver co-doped hydroxyapatite as prospective materials for bone implants

Huang, Yong; Xu, Zhiwei; Zhang, Xuejiao; Chang, Xiaotong; Zhang, Xiaoyun; Li, Yichao; Ye, Ting; Han, Rui; Han, Shuguang; Gao, Yuan; Du, Xuan; Yang, Haijian

doi:10.1016/j.jallcom.2016.12.139

Cited by 76 publications

(55 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Titanium (Ti) is widely applied in the clinic, however, due to it being bio-inert, various approaches had been applied to fabricate biofunctional Ti implants with immobilized bioactive components including hydroxylapatite (HA), silicate or strontium/sliver doped HA, antibiotics, trace elements, and antimicrobial peptides (AMPs). [1][2][3][4][5] Among them, AMPs are a new class of antibiotics. Unlike traditional antibiotics, they have broad-spectrum antimicrobial ability with lower cytotoxicity and accordingly, they have the potential to replace the use of antibiotics.…”

Section: Introductionmentioning

confidence: 99%

A comparative analysis of antibacterial properties and inflammatory responses for the KR-12 peptide on titanium and PEGylated titanium surfaces

Nie

Long

et al. 2017

RSC Adv.

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

A comparative analysis of antibacterial properties and inflammatory responses for the KR-12 peptide on titanium and PEGylated titanium surfaces

Nie

Long

et al. 2017

RSC Adv.

View full text Add to dashboard Cite

show abstract

“…16,17 The TN arrays were prepared by the standard two-electrode anodization at room temperature in the potentiostatic mode. The cathode was a platinum plate, and the anode was the Ti sample.…”

Section: Methodsmentioning

confidence: 99%

“…16 The electrochemical measurement process was explained elsewhere. 17 The MC3T3-E1 mouse preosteoblasts (Cell Bank of Chinese Academy of Sciences, Shanghai, China) were incubated at 37°C in a 5% CO 2 environment in α-minimum essential medium with 10% fetal bovine serum and 1% streptomycin/ penicillin.…”

Section: Methodsmentioning

confidence: 99%

“…Thereafter, the unattached cells were removed through gentle washing with phosphate-buffered saline at 37°C; then, the adhering cells were immersed in a 4% paraformaldehyde solution for 10 min and were then stained using phalloidin (5 μg/mL; Sigma-Aldrich Co., St Louis, MO, USA) and 4′,6-diamidino-2-phenylindole. Fluorescence images of the adhering cells were obtained by a stereomicroscope (model SMZ745/745T; Nikon Corporation, Tokyo, Japan) (for the details on the assay processes of cell morphology and alkaline phosphatase [ALP] activity, refer Huang et al 16,17 ).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Biofunctional Sr- and Si-loaded titania nanotube coating of Ti surfaces by anodization-hydrothermal process

Huang¹,

Shen²,

Qiao³

et al. 2018

IJN

Self Cite

View full text Add to dashboard Cite

Background Two frequent problems associated with titanium (Ti) surfaces of bone/dental implants are their corrosion and lack of native tissue integration. Methods Here, we present an anodization-hydrothermal method for coating Ti surfaces with a layer of silicon (Si)- and strontium (Sr)-loaded titania nanotubes (TNs). The Ti surfaces coated with such a layer (Si–Sr-TNs) were characterized with different techniques. Results The results indicate that the Si 4+ and Sr 2+ ions were evenly incorporated into the TNs and that the Si–Sr-TN layer provides good protection against corrosive media like simulated body fluid. The excellent cytocompatibility of the coating was confirmed in vitro by the significant growth and differentiation of MC3T3-E1 osteoblastic cells. Conclusion Being easily and economically fabricated, the Si–Sr-TN surfaces may find their niche in clinical applications, thanks to their excellent biological activity and corrosion resistance.

show abstract

“…The third is fabrication of graphene-metal contacts for various devices [2,4,19,21], and the fourth is application of graphene-metal composites as catalysts [18,19,25]. Additional motivation for the studying of graphene/metal interfaces is the production of biocompatible stable nanoparticles [27,28] and its further functionalization for tearapeutic and drug delivery applications. However, further developments in the area of graphene-metal interfaces require understanding the influences of the quality of metallic substrate on the electronic structure of graphene and its stability.…”

Section: Introductionmentioning

confidence: 99%

Atomic and electronic structure of a copper/graphene interface as prepared and 1.5 years after

Boukhvalov

Bazylewski

Kukharenko

et al. 2017

Applied Surface Science

View full text Add to dashboard Cite

We report the results of X-ray spectroscopy and Raman measurements of as-prepared graphene on a high quality copper surface and the same materials after 1.5 years under different conditions (ambient and low humidity). The obtained results were compared with density functional theory calculations of the formation energies and electronic structures of various structural defects in graphene/Cu interfaces. For evaluation of the stability of the carbon cover, we propose a two-step model. The first step is oxidation of the graphene, and the second is perforation of graphene with the removal of carbon atoms as part of the carbon dioxide molecule. Results of the modeling and experimental measurements provide evidence that graphene grown on high-quality copper substrate becomes robust and stable in time (1.5 years). However, the stability of this interface depends on the quality of the graphene and the number of native defects in the graphene and substrate. The effect of the presence of a metallic substrate with defects on the stability and electronic structure of graphene is also discussed.

show abstract

Nanotube-formed Ti substrates coated with silicate/silver co-doped hydroxyapatite as prospective materials for bone implants

Cited by 76 publications

References 77 publications

A comparative analysis of antibacterial properties and inflammatory responses for the KR-12 peptide on titanium and PEGylated titanium surfaces

A comparative analysis of antibacterial properties and inflammatory responses for the KR-12 peptide on titanium and PEGylated titanium surfaces

Biofunctional Sr- and Si-loaded titania nanotube coating of Ti surfaces by anodization-hydrothermal process

Atomic and electronic structure of a copper/graphene interface as prepared and 1.5 years after

Contact Info

Product

Resources

About