Nanotransducers for wireless neuromodulation

Li, Xiuying; Xiong, Hejian; Rommelfanger, Nicholas J.; Xu, Xueqi; Youn, Jonghae; Slesinger, Paul A.; Hong, Guosong; Qin, Zhenpeng

doi:10.1016/j.matt.2021.02.012

Cited by 23 publications

(26 citation statements)

References 167 publications

(215 reference statements)

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“…However, despite the vast applications for deep-penetrating and transcranial optical theranostics, [21][22][23][24][25][26] the NIR-II light has not been investigated for transcranial nongenetic neuromodulation. [27] On the other hand, precise spatiotemporal-controlled neuromodulation is the intrinsic pursuit in neurological research. [1][2][3][4] Classical strategies such as optogenetics can dissect specific neural circuits by selectively modulating the neuron subtypes.…”

Section: Introductionmentioning

confidence: 99%

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Transcranial Nongenetic Neuromodulation via Bioinspired Vesicle‐Enabled Precise NIR‐II Optical Stimulation

et al. 2022

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Regulating the activity of specific neurons is essentially important in neurocircuit dissection and neuropathy therapy. As a recently developed strategy, nanomaterial‐enabled nongenetic neuromodulations that realize remote physical stimuli have made vast progress and shown great clinical potential. However, minimal invasiveness and high spatiotemporal resolution are still challenging for nongenetic neuromodulation. Herein, a second near‐infrared (NIR‐II)‐light‐induced transcranial nongenetic neurostimulation via bioinspired nanovesicles is reported. The rationally designed vesicles are obtained from vesicle‐membrane‐confined enzymatic reactions. This study demonstrates that the vesicle‐enabled NIR‐II photothermal stimuli can elicit neuronal signaling dynamics with precise spatiotemporal control and thus evoke defined neural circuits in nontransgenic mice. Moreover, the vesicle‐mediated NIR‐II optical stimulation can regulate mouse motor behaviors with minimal invasiveness by eliminating light‐emitting implants. Furthermore, the biological modulation is integrated with photoacoustic brain imaging, realizing navigational, and efficient neuromodulation. Such transcranial and precise NIR‐II optical neuromodulation mediated by bioinspired vesicles shows the potential for the optical‐theranostics of neurological diseases in nontransgenic organisms.

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Section: Introductionmentioning

confidence: 99%

“…However, despite the vast applications for deep‐penetrating and transcranial optical theranostics, [ 21–26 ] the NIR‐II light has not been investigated for transcranial nongenetic neuromodulation. [ 27 ]…”

Section: Introductionmentioning

confidence: 99%

Transcranial Nongenetic Neuromodulation via Bioinspired Vesicle‐Enabled Precise NIR‐II Optical Stimulation

et al. 2022

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“…[8][9][10] However, their low up-conversion emission efficiency (<9%) restricts their full potential. 2,7,9,11 To overcome this disadvantage, great efforts have been made, including the use of different host matrices, such as single crystals, glasses, and glass-ceramic materials. Host matrices with low phonon energy (e.g., NaYF 4 -350 cm À1 , ZBLAN -330 cm À1 , chalcogenide glasses -300 cm À1 , uoroindate glasses -510 cm À1 ) have been found to enhance the up-conversion emission process because of the suppression of non-radiative losses.…”

Section: Introductionmentioning

confidence: 99%

“…8–10 However, their low up-conversion emission efficiency (<9%) restricts their full potential. 2,7,9,11…”

Section: Introductionmentioning

confidence: 99%

Highly efficient green up-conversion emission from fluoroindate glass nanoparticles functionalized with a biocompatible polymer

et al. 2022

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“…For this problem, exploring novel brain modulation techniques that satisfy the requirements of research and clinical application should be explored. Ideal brain stimulation targeting deep brain regions should be noninvasive or minimally invasive and have a high spatiotemporal resolution and negligible inflammatory or complications in different animal models, including rodents, large mammals, non-human primates, and humans (Li et al, 2021 ). Great advances have been achieved by neuromodulation studies in the past decade, driven by improvements in methods and devices.…”

Section: Introductionmentioning

confidence: 99%

Review of Noninvasive or Minimally Invasive Deep Brain Stimulation

Liu

Qiu

Hou

et al. 2022

Front. Behav. Neurosci.

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Brain stimulation is a critical technique in neuroscience research and clinical application. Traditional transcranial brain stimulation techniques, such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), and deep brain stimulation (DBS) have been widely investigated in neuroscience for decades. However, TMS and tDCS have poor spatial resolution and penetration depth, and DBS requires electrode implantation in deep brain structures. These disadvantages have limited the clinical applications of these techniques. Owing to developments in science and technology, substantial advances in noninvasive and precise deep stimulation have been achieved by neuromodulation studies. Second-generation brain stimulation techniques that mainly rely on acoustic, electronic, optical, and magnetic signals, such as focused ultrasound, temporal interference, near-infrared optogenetic, and nanomaterial-enabled magnetic stimulation, offer great prospects for neuromodulation. This review summarized the mechanisms, development, applications, and strengths of these techniques and the prospects and challenges in their development. We believe that these second-generation brain stimulation techniques pave the way for brain disorder therapy.

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Nanotransducers for wireless neuromodulation

Cited by 23 publications

References 167 publications

Transcranial Nongenetic Neuromodulation via Bioinspired Vesicle‐Enabled Precise NIR‐II Optical Stimulation

Transcranial Nongenetic Neuromodulation via Bioinspired Vesicle‐Enabled Precise NIR‐II Optical Stimulation

Highly efficient green up-conversion emission from fluoroindate glass nanoparticles functionalized with a biocompatible polymer

Review of Noninvasive or Minimally Invasive Deep Brain Stimulation

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