Nanotoxicological evaluation of oxidative responses in rat nephrocytes induced by cadmium

Trabelsi, H.; Azzouz, Inès; Ferchichi, Soumaya; Tebourbi, Olfa; Sakly, Mohsen; Abdelmelek, Hafedh

doi:10.2147/ijn.s49323

Cited by 38 publications

(26 citation statements)

References 51 publications

(64 reference statements)

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“…According to this ratio, the decrease in MDA level is concomitant to the increase in the (ZnX) nanoparticle number. A similar result was previously described by Trabelsi et al 13 …”

supporting

confidence: 91%

“…Images were obtained with 40× enlargement. 13 Powder samples preparation and X-ray diffraction (XrD) measurements At 14 days postintraperitoneal injection, the control and treated groups were sacrificed and their livers harvested. The tissues were weighed, rinsed with ice-cold deionized water and dried with filter paper.…”

Section: Fluorescence Microscopymentioning

confidence: 99%

“…Trabelsi et al reported that the interaction of Cd with some kidneys elements could generate red fluorescent quantum dots like CdS and/or CdSe. 13 Fluorescence microscopy images showed that cotreatment with zinc and selenium enhanced the intensity of the red fluorescence signal in rat liver compared to the zinc-group. The origin of these fluorescence signals can be explained by the biosynthesis of ZnS and/or ZnSe nanoparticles in rat liver.…”

mentioning

confidence: 95%

“…10,11 Recently, Trabelsi et al demonstrated that subacute exposure to cadmium (Cd) generates nanocomplexes (CdS and/or CdSe) at cellular levels in the liver and kidneys. 12,13 The authors reported that Se decreases the oxidative responses by enhancing the biosynthesis of nanocomplexes (CdSe and/or CdS) in rat nephrocytes. This biosynthesis may represent a detoxification pathway after Cd treatment.…”

Section: Introductionmentioning

confidence: 99%

“…Hence, the biosynthesis of nanoparticles ameliorates the oxidative responses and decreases damage caused by cadmium in hepatocytes. 13 The aim of this study was to investigate the eventual interaction between Zn and sulfur (S) and/or Se at cellular levels in the liver. These interactions could be understood in terms of nanocomplex biosynthesis and the modulation of oxidative responses.…”

Section: Introductionmentioning

confidence: 99%

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Interaction between nanoparticles generated by zinc chloride treatment and oxidative responses in rat liver

Azzouz¹,

Trabelsi²,

Hanini³

et al. 2013

IJN

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The aim of the present study was to investigate the interaction of zinc chloride (3 mg/kg, intraperitoneally [ip]) in rat liver in terms of the biosynthesis of nanoparticles. Zinc treatment increased zinc content in rat liver. Analysis of fluorescence revealed the presence of red fluorescence in the liver following zinc treatment. Interestingly, the co-exposure to zinc (3 mg/kg, ip) and selenium (0.20 mg/L, per os [by mouth]) led to a higher intensity of red fluorescence compared to zinc-treated rats. In addition, X-ray diffraction measurements carried out on liver fractions of zinc-treated rats point to the biosynthesis of zinc sulfide and/or selenide nanocomplexes at nearly 51.60 nm in size. Moreover, co-exposure led to nanocomplexes of about 72.60 nm in size. The interaction of zinc with other mineral elements (S, Se) generates several nanocomplexes, such as ZnS and/or ZnSe. The nanocomplex ZnX could interact directly with enzyme activity or indirectly by the disruption of mineral elements’ bioavailability in cells. Subacute zinc or selenium treatment decreased malondialdehyde levels, indicating a drop in lipid peroxidation. In addition, antioxidant enzyme assays showed that treatment with zinc or co-treatment with zinc and selenium increased the activities of glutathione peroxidase, catalase, and superoxide dismutase. Consequently, zinc complexation with sulfur and/or selenium at nanoscale level could enhance antioxidative responses, which is correlated to the ratio of number of ZnX nanoparticles (X=sulfur or X=selenium) to malondialdehyde level in rat liver.

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“…According to this ratio, the decrease in MDA level is concomitant to the increase in the (ZnX) nanoparticle number. A similar result was previously described by Trabelsi et al 13 …”

supporting

confidence: 91%

Section: Fluorescence Microscopymentioning

confidence: 99%

mentioning

confidence: 95%