Nanotoxicity: The Toxicity Research Progress of Metal and Metal- Containing Nanoparticles

Ding, Lingling; Liu, Zhidong; Aggrey, Mike Okweesi; Li, Chunhua; Chen, Jing; Tong, Ling

doi:10.2174/138955751507150424104334

Cited by 45 publications

(20 citation statements)

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“…Our recent work provides the first demonstration that autophagy activated by silver nanoparticles (AgNPs) in normal cells fails to trigger lysosomal degradation pathway and led to a toxicity phenomenon called defective autophagic flux or autophagy dysfunction, which is relevant to the accelerated cellular pathogenesis of diseases [18][19][20]. The toxic effects induced by AgNPs and some of the metal oxide NPs, such as ZnONPs, have been shown, either in vitro or in vivo, to be quite similar in terms of cytotoxicity, genotoxicity, hematotoxicity, immunotoxicity, hepatotoxicity, and embryotoxicity [19,21]. A more profound understanding of these toxicity mechanisms will facilitate the development of prevention and intervention policies against adverse outcomes induced by metal and metal oxide nanomaterials.…”

Section: Introductionmentioning

confidence: 99%

The Current Understanding of Autophagy in Nanomaterial Toxicity and Its Implementation in Safety Assessment-Related Alternative Testing Strategies

Chen

Liao

et al. 2020

IJMS

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Nanotechnology has rapidly promoted the development of a new generation of industrial and commercial products; however, it has also raised some concerns about human health and safety. To evaluate the toxicity of the great diversity of nanomaterials (NMs) in the traditional manner, a tremendous number of safety assessments and a very large number of animals would be required. For this reason, it is necessary to consider the use of alternative testing strategies or methods that reduce, refine, or replace (3Rs) the use of animals for assessing the toxicity of NMs. Autophagy is considered an early indicator of NM interactions with cells and has been recently recognized as an important form of cell death in nanoparticle-induced toxicity. Impairment of autophagy is related to the accelerated pathogenesis of diseases. By using mechanism-based high-throughput screening in vitro, we can predict the NMs that may lead to the generation of disease outcomes in vivo. Thus, a tiered testing strategy is suggested that includes a set of standardized assays in relevant human cell lines followed by critical validation studies carried out in animals or whole organism models such as C. elegans (Caenorhabditis elegans), zebrafish (Danio rerio), and Drosophila (Drosophila melanogaster)for improved screening of NM safety. A thorough understanding of the mechanisms by which NMs perturb biological systems, including autophagy induction, is critical for a more comprehensive elucidation of nanotoxicity. A more profound understanding of toxicity mechanisms will also facilitate the development of prevention and intervention policies against adverse outcomes induced by NMs. The development of a tiered testing strategy for NM hazard assessment not only promotes a more widespread adoption of non-rodent or 3R principles but also makes nanotoxicology testing more ethical, relevant, and cost- and time-efficient.

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Section: Introductionmentioning

confidence: 99%

The Current Understanding of Autophagy in Nanomaterial Toxicity and Its Implementation in Safety Assessment-Related Alternative Testing Strategies

Chen

Liao

et al. 2020

IJMS

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“…Since chemically synthesized nanovectors are known to induce toxicity [24][25][26][27], which is a major obstacle for clinical use, the approach combining PEI and GNVs as we demonstrated in this study could apply to nanotechnology in general to overcome the potential toxicity for clinical application.…”

Section: Discussionmentioning

confidence: 97%

Grapefruit-derived Nanovectors Delivering Therapeutic miR17 Through an Intranasal Route Inhibit Brain Tumor Progression

et al. 2016

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The lack of access to the brain is a major obstacle for central nervous system drug development. In this study, we demonstrate the capability of a grapefruit-derived nanovector (GNV) to carry miR17 for therapeutic treatment of mouse brain tumor. We show that GNVs coated with folic acid (FA-GNVs) are enhanced for targeting the GNVs to a folate receptor-positive GL-26 brain tumor. Additionally, FA-GNV-coated polyethylenimine (FA-pGNVs) not only enhance the capacity to carry RNA, but the toxicity of the polyethylenimine is eliminated by the GNVs. Intranasal administration of miR17 carried by FA-pGNVs led to rapid delivery of miR17 to the brain that was selectively taken up by GL-26 tumor cells. Mice treated intranasally with FA-pGNV/miR17 had delayed brain tumor growth. Our results demonstrate that this strategy may provide a noninvasive therapeutic approach for treating brain-related disease through intranasal delivery.

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“…The second group received conventional iron oxide 15 mg/kg intraperitoneally (ip) for 16 days (10). The third group received iron oxide nanoparticles 5 mg/kg ip for 16 days (nano 5) (4).…”

Section: Animal Groupingmentioning

confidence: 99%

“…More chemical reaction of nanomaterials leads to increase of the generation of free radicals such as reactive oxygen species (ROS), which damage cell membranes and these radicals lead to inflammation and death of cells by increasing lipid peroxidation. ROS production is observed in the diverse range of nanomaterials including metal oxide nanoparticles (9,10). Although several studies are done on the impact of iron oxide on different tissue and oxidative stress, limited resources are available to evaluate the impact of iron oxide and conventional iron nanoparticles on body tissue including reproductive organs.…”

Section: Introductionmentioning

confidence: 99%

Accumulation of Iron Oxide Nanoparticle and Conventional Iron Oxide in Rat Ovary and Oxidative Stress Caused by It

Poormoosavi

Morovvati

Varzi

et al. 2018

Iran Red Crescent Med J

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Background: Iron is one of the most essential elements of life that plays a major role in structure of the most cells of body and is potentially toxic and dangerous, because it easily participates in oxidation-reduction reactions and produces reactive oxygen species, which leads to oxidative stress; nanomaterials such as iron nanoparticles found in environmental pollution and can also be dangerous. Objectives:The current study aimed at evaluating and comparing the effects of accumulation of conventional iron oxide and iron oxide nanoparticles in rat ovary and its relationship with serum oxidative stress. Methods:The current experimental study was conducted on 5 groups of female rats, control, iron oxide (15 mg/kg), and iron oxide nanoparticles (5, 15, and 45 mg/kg). All rats were treated intraperitoneally for 16 days. Then, they were euthanized and their ovarian tissue was removed, and iron accumulation in the ovaries was measured by atomic absorption. Malondialdehyde (MDA), carbonyl protein, thiol protein, and total antioxidant activity were also measured in rats serum samples.Results: According to the current study findings, iron accumulation increased significantly (P = 0.046) in the group that received conventional iron oxide, as compared with the control group. Also, the mean of total antioxidant activity (4.4 ± 294.31 µM/L) and thiol protein (3.3 ± 381.09 µm/mL) showed a significant (P ≤ 0.05) differences in group that received conventional iron oxide, compared with the other groups, MDA and protein carbonyl had no significant (P ≥ 0.05) difference. Conclusions:According to the findings, conventional iron oxide particle induced more accumulation and more oxidative stress than nanoparticles.

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Nanotoxicity: The Toxicity Research Progress of Metal and Metal- Containing Nanoparticles

Cited by 45 publications

References 0 publications

The Current Understanding of Autophagy in Nanomaterial Toxicity and Its Implementation in Safety Assessment-Related Alternative Testing Strategies

The Current Understanding of Autophagy in Nanomaterial Toxicity and Its Implementation in Safety Assessment-Related Alternative Testing Strategies

Grapefruit-derived Nanovectors Delivering Therapeutic miR17 Through an Intranasal Route Inhibit Brain Tumor Progression

Accumulation of Iron Oxide Nanoparticle and Conventional Iron Oxide in Rat Ovary and Oxidative Stress Caused by It

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