2014
DOI: 10.3390/ijms15033671
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Nanotoxicity Overview: Nano-Threat to Susceptible Populations

Abstract: Due to the increasing applications of nanomaterials and nanotechnology, potential danger of nanoparticle exposure has become a critical issue. However, recent nanotoxicity studies have mainly focused on the health risks to healthy adult population. The nanotoxicity effects on susceptible populations (such as pregnant, neonate, diseased, and aged populations) have been overlooked. Due to the alterations in physiological structures and functions in susceptible populations, they often suffer more damage from the … Show more

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Cited by 90 publications
(61 citation statements)
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“…1 Nanomaterial-induced toxicity has been observed in human and other lives via mechanisms related to oxidative stress, 2 inflammatory response, 35 protein binding, 6 ion influx disturbance, 7 and dissolution and release of toxic ions. It is currently accepted that oxidative stress and inflammation are the major mechanisms of nanotoxicity.…”
Section: Introductionmentioning
confidence: 99%
“…1 Nanomaterial-induced toxicity has been observed in human and other lives via mechanisms related to oxidative stress, 2 inflammatory response, 35 protein binding, 6 ion influx disturbance, 7 and dissolution and release of toxic ions. It is currently accepted that oxidative stress and inflammation are the major mechanisms of nanotoxicity.…”
Section: Introductionmentioning
confidence: 99%
“…1,2 In particular, gold nanoparticles (AuNPs) are a potential candidate for the development of diagnostic and therapeutic methods, due to their unique physical, chemical, optical, and pharmacological properties. For example, gold cores are inert, stable, biocompatible, and have low toxicity.…”
Section: Introductionmentioning
confidence: 99%
“…Life stage in which NP exposure may occur seems a critical aspect in determining susceptibility to nanomaterial induced adverse health effects, particularly as concerns elderly and youth. Aging is a complex physiological process characterized by the decline of cellular and organic functions which may predispose elderly to certain metabolic, cardiovascular, respiratory, and neurological diseases which may be aggravated by NP exposures or in turn may increase the susceptibility to NP adverse effects (Li et al, 2014). Considering the aging of the active working population, the appropriate management of occupational risks in balance with emerging age-related functional limitations appears a challenging issue.…”
Section: Resultsmentioning
confidence: 99%