Nanotherapeutics: An insight into healthcare and multi-dimensional applications in medical sector of the modern world

Prasad, Minakshi; Lambe, Upendra P.; Brar, Basanti; Shah, Ikbal; Manimegalai, J; Ranjan, Koushlesh; Rao, Rekha; Kumar, Sunil; Mahant, Sheefali; Khurana, Sandip Kumar; Iqbal, Hafiz M.N.; Dhama, Kuldeep; Misri, Jyoti; Prasad, Gaya

doi:10.1016/j.biopha.2017.11.026

Cited by 252 publications

(120 citation statements)

References 191 publications

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“…However, the limited survival rate of transplanted cells retarded the application of the stem cell therapy technology. One way to address this challenge is using suitable scaffolds to boost the viability of stem cells …”

Section: Discussionmentioning

confidence: 99%

PGS Scaffolds Promote the In Vivo Survival and Directional Differentiation of Bone Marrow Mesenchymal Stem Cells Restoring the Morphology and Function of Wounded Rat Uterus

Xiao

Yang

Lei

et al. 2019

Adv Healthcare Materials

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Intrauterine adhesion (IUA) causing infertility and recurrent miscarriage of reproductive female mammals usually results from endometrium injury. Nevertheless, there is no efficient therapeutic method to avoid IUA. Bone marrow derived mesenchymal stem cells (BMSCs) are an important cell source for tissue regeneration. This study designs and explores the ability of BMSC‐loaded elastic poly(glycerol sebacate) (PGS) scaffold to prevent IUA and compares the effect of PGS with poly(lactic‐co‐glycolic acid) (PLGA) and collagen scaffolds in resumption of damaged rat uteruses. The 3D architecture provided by PGS scaffolds favors the attachment and growth of rat BMSCs. In vivo bioluminescence imaging shows that compared with direct BMSC intrauterine injection, PLGA, and collagen scaffolds, the PGS scaffold significantly prolongs the retention time of BMSCs in a wounded rat uterus model. More importantly, BMSCs can directly differentiate into endometrial stromal cells after transplantation of PGS/BMSCs constructs, but not PLGA/BMSCs and collagen/BMSCs. It is found that the level of transforming growth factor β1 (TGF‐β1), basic fibroblast growth factor (bFGF), vascular endothelial growth factor, and insulin‐like growth factors in the injured endometrium adjacent to PGS/BMSCs constructs is higher than those of rats receiving PLGA/BMSCs, collagen/BMSCs, or BMSCs intrauterine transplantation. Besides, transplantation of PGS/BMSCs leads to better morphology recovery of the damaged uterus than PLGA/BMSCs and collagen/BMSCs. The receptive fertility of PGS/BMSCs is 72.2 ± 6.4%, similar to the one of collagen/BMSCs, but significantly higher than 42.3 ± 3.9% in PLGA/BMSCs. Taken together, PGS/BMSCs may be a promising candidate for preventing IUA.

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Section: Discussionmentioning

confidence: 99%

PGS Scaffolds Promote the In Vivo Survival and Directional Differentiation of Bone Marrow Mesenchymal Stem Cells Restoring the Morphology and Function of Wounded Rat Uterus

Xiao

Yang

Lei

et al. 2019

Adv Healthcare Materials

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“…Multiple beneficial health applications including the potent antimicrobial properties, medicinal and therapeutic values of Emblica officinalis need to be promoted and propagated with more researches and clinical trials, validation studies, promotional activities along with exploration of advances in biotechnology, pharmacology, pharmaceuticals, nanotechnology based approaches for developing effective drugs and medicines utilizing Amla 6, [15][16][17]24,75,139,[163][164][165] . Particularly, in the scenario of rising drug resistance, higher incidences of emerging and reemerging pathogenic microbes, the antimicrobial efficacy of Emblica officinalis can be exploited for important microbial pathogens including food-borne zoonotic bacteria such as Salmonella, Arcobacters, Camyplobacters, and emerging viral pathogens like Zika, Ebola, Nipah virus and others, so as to lessen their high incidences, devastating effects and public health effects; since various other herbs and plant metabolites / extracts have shown promising results against such pathogens 5,6,[166][167][168][169] .…”

Section: Other Potential Health Applications Of Amlamentioning

confidence: 99%

Emblica officinalis (Amla) with a Particular Focus on Its Antimicrobial Potentials: A Review

Khurana¹,

Tiwari²,

Sharun³

et al. 2019

J Pure Appl Microbiol

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“…Nano-systems are often used or presented as nanometric platforms with a backbone made of various elements such as vesicles (lipidic, micellar, polymeric or exosomes), linear polymers, metals (Au, Gd, graphene), carbon dots, nano-implants, dendrimers [7], inside or at the surface of which are inserted both active anti-GBM principles such as immune cells, chemotherapeutic/anti-angiogenic drugs or sensitizers, as well as moieties, which either target GBM cellular receptors/angiogenic blood vessels or open the BBB, and therefore help the active principles to reach GBM tumor cells [8]. These nano-systems can also be associated with fluorescent/radioactive compounds to enable their localization in the organism [9].…”

Section: Different Types Of Nano-systems For Gbm Treatmentmentioning

confidence: 99%

Nano-Therapies for Glioblastoma Treatment

Alphandéry

2020

Cancers

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Traditional anti-cancer treatments are inefficient against glioblastoma, which remains one of the deadliest and most aggressive cancers. Nano-drugs could help to improve this situation by enabling: (i) an increase of anti-glioblastoma multiforme (GBM) activity of chemo/gene therapeutic drugs, notably by an improved diffusion of these drugs through the blood brain barrier (BBB), (ii) the sensibilization of radio-resistant GBM tumor cells to radiotherapy, (iii) the removal by surgery of infiltrating GBM tumor cells, (iv) the restoration of an apoptotic mechanism of GBM cellular death, (v) the destruction of angiogenic blood vessels, (vi) the stimulation of anti-tumor immune cells, e.g., T cells, NK cells, and the neutralization of pro-tumoral immune cells, e.g., Treg cells, (vii) the local production of heat or radical oxygen species (ROS), and (viii) the controlled release/activation of anti-GBM drugs following the application of a stimulus. This review covers these different aspects.

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Nanotherapeutics: An insight into healthcare and multi-dimensional applications in medical sector of the modern world

Cited by 252 publications

References 191 publications

PGS Scaffolds Promote the In Vivo Survival and Directional Differentiation of Bone Marrow Mesenchymal Stem Cells Restoring the Morphology and Function of Wounded Rat Uterus

PGS Scaffolds Promote the In Vivo Survival and Directional Differentiation of Bone Marrow Mesenchymal Stem Cells Restoring the Morphology and Function of Wounded Rat Uterus

Emblica officinalis (Amla) with a Particular Focus on Its Antimicrobial Potentials: A Review

Nano-Therapies for Glioblastoma Treatment

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