Nanotheranostics: Nanoparticles Applications, Perspectives, and Challenges

Ojha, Atul Kumar; Rajasekaran, Ragavi; Pandey, Anurag Kumar; Dutta, Abir; Seesala, Venkata Sundeep; Das, Subrata; Chaudhury, Koel; Dhara, Santanu

doi:10.1007/978-981-16-2782-8_14

Cited by 5 publications

(5 citation statements)

References 136 publications

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“…This model didn't consider various factors such as vascular density, distribution of the blood vessel in the tumor, the thickness of stromal cells, and the presence of macrophages. Each of these factors plays a distinctive role in intertumoral drug distribution and each tumor should be treated as a separate organ [108,109]. In general, all tumors are considered to be highly vascular organs but there is a lot of variation in different types of tumors regarding vascularity [110].…”

Section: Future Challenges and Problemsmentioning

confidence: 99%

Current status of Cancer Nanotheranostics: Emerging strategies for cancer management

Chavda¹,

Khadela²,

Shah³

et al. 2023

Nanotheranostics

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Cancer diagnosis and management have been a slow-evolving area in medical science. Conventional therapies have by far proved to have various limitations. Also, the concept of immunotherapy which was thought to revolutionize the management of cancer has presented its range of drawbacks. To overcome these limitations nanoparticulate-derived diagnostic and therapeutic strategies are emerging. These nanomaterials are to be explored as they serve as a prospect for cancer theranostics. Nanoparticles have a significant yet unclear role in screening as well as therapy of cancer. However, nanogels and Photodynamic therapy is one such approach to be developed in cancer theranostics. Photoactive cancer theranostics is a vivid area that might prove to help manage cancer. Also, the utilization of the quantum dots as a diagnostic tool and to selectively kill cancer cells, especially in CNS tumors. Additionally, the redox-sensitive micelles targeting the tumor microenvironment of the cancer are also an important theranostic tool. This review focuses on exploring various agents that are currently being studied or can further be studied as cancer theranostics.

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Section: Future Challenges and Problemsmentioning

confidence: 99%

Current status of Cancer Nanotheranostics: Emerging strategies for cancer management

Chavda¹,

Khadela²,

Shah³

et al. 2023

Nanotheranostics

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“…For example, at translation at the clinical and preclinical stage. The effectiveness of theranostic drugs is dependent upon heterogeneity at the cell-specified target and is not recommended for a broader range of patients due to its nature of personalised treatment (Ojha, 2021). In addition, nanoparticles can have toxic effects on the body which require thorough evaluation, and their distribution throughout the body can be difficult due to the autoimmune response (defence system) of the human body (Ojha, 2021).…”

Section: Research Gapmentioning

confidence: 99%

“…The effectiveness of theranostic drugs is dependent upon heterogeneity at the cell-specified target and is not recommended for a broader range of patients due to its nature of personalised treatment (Ojha, 2021). In addition, nanoparticles can have toxic effects on the body which require thorough evaluation, and their distribution throughout the body can be difficult due to the autoimmune response (defence system) of the human body (Ojha, 2021). Furthermore, the interaction of nanotheranostics with biomolecules such as proteins and nucleic acids can affect their performance due to factors such as surface properties and patterns.…”

Section: Research Gapmentioning

confidence: 99%

Revolutionising Cancer Diagnosis and Treatment: A Review on Advancements in Nanomaterial-based Theranostics

Jabarkhil,

Azizi,

Imam

et al. 2023

IJEMM

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The persistent struggle against cancer has given rise to the development of nanotheranostics, a domain that integrates therapeutic and diagnostic capabilities within nanoscale structures. This paper explores advancements in nanomaterials and nanoparticles for cancer nanotheranostics, focusing on their design, significance, and applications. The incorporation of biocompatible nanoparticles in cancer therapy offers personalised, targeted approaches while minimising side effects. The use of nanomaterials such as metals, polymers, and lipids enable precise drug delivery and imaging. Various imaging modalities, including ultrasound and fluorescence, complement therapeutic strategies for enhanced precision. Critical parameters for nanomaterial selection and design are discussed, emphasising biocompatibility, targeting efficiency, and drug delivery capacity. Biocompatibility ensures safe interactions within biological systems, requiring mitigation of toxicological concerns through strategies like anti-inflammatory peptides or ligand-functionalization. Targeting efficiency combines passive and active targeting to enhance specificity, reshaping cancer diagnostics and therapy. Drug delivery capacity is achieved through engineered core-shell structures with distinct properties, including liposomes, micelles, and dendrimers, each tailored for targeted therapy and imaging. This paper also discusses the advancements in the field of cancer treatment using nanotheranostics and its economic impact on the Canadian healthcare systems while following the ethical guidelines towards patients’ consent, privacy, and the proper use of emerging technologies.

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“…78 , 79 However, the use of QDs in bioimaging is limited due to their low specificity and inability to detect early-stage cancer tumors. 80 Produced QDs by biological sources make these QDs biocompatible in bioimaging and anti-cancer drug applications. In fact, different metals may normally be non-toxic in the body but become toxic when their structure is at the quantum level.…”

Section: Diagnosis and Treatment Of Cancermentioning

confidence: 99%

Biosynthesis of Quantum Dots and Their Therapeutic Applications in the Diagnosis and Treatment of Cancer and SARS-CoV-2

et al. 2022

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Quantum dots (QDs) are semiconductor materials that range from 2 to 10 nanometers. These nanomaterials (NMs) are smaller and have more unique properties compared to conventional nanoparticles (NPs). One of the unique properties of QDs is their special optoelectronic properties, making it possible to apply these NMs in bioimaging. Different size and shape QDs, which are used in various fields such as bioimaging, biosensing, cancer therapy, and drug delivery, have so far been produced by chemical methods. However, chemical synthesis provides expensive routes and causes serious environmental and health issues. Therefore, various biological systems such as bacteria, fungi, yeasts, algae, and plants are considered as potent eco-friendly green nanofactories for the biosynthesis of QDs, which are both economic and environmentally safe. The review aims to provide a descriptive overview of the various microbial agents for the synthesis of QDs and their biomedical applications for the diagnosis and treatment of cancer and SARS-CoV-2.

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Nanotheranostics: Nanoparticles Applications, Perspectives, and Challenges

Cited by 5 publications

References 136 publications

Current status of Cancer Nanotheranostics: Emerging strategies for cancer management

Current status of Cancer Nanotheranostics: Emerging strategies for cancer management

Revolutionising Cancer Diagnosis and Treatment: A Review on Advancements in Nanomaterial-based Theranostics

Biosynthesis of Quantum Dots and Their Therapeutic Applications in the Diagnosis and Treatment of Cancer and SARS-CoV-2

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