Nanotheranostics: Molecular Diagnostics and Nanotherapeutic Evaluation by Photoacoustic/Ultrasound Imaging in Small Animals

Dhamija, Piyush; Mehata, Abhishesh Kumar; Setia, Aseem; Priya, Vishnu; Malik, Ankit Kumar; Bonlawar, Jyoti; Verma, Nidhi; Badgujar, Paresh; Randhave, Nandini; Muthu, Madaswamy S.

doi:10.1021/acs.molpharmaceut.3c00708

Cited by 6 publications

(4 citation statements)

References 168 publications

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“…Nanotheranostics made of polymer-drug conjugates are the subject of active research involving a wide range of polymers 89 . Their potential for use in nanotheranostic applications is enhanced by the fact that the polymer chain contains free functional groups that can be linked with various agents, including imaging, targeting, and therapeutic moieties 90 . When making PDCs, a combination of natural and synthetic polymers is utilised.…”

Section: Nanotheranostics Of Anticancer Drug Induced Cardiac Toxicitymentioning

confidence: 99%

Nanomedicine And Nanotheranostics: Special Focus on Imaging of Anticancer Drugs Induced Cardiac Toxicity

Setia,

Challa,

Vallamkonda

et al. 2024

Nanotheranostics

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Section: Nanotheranostics Of Anticancer Drug Induced Cardiac Toxicitymentioning

confidence: 99%

Nanomedicine And Nanotheranostics: Special Focus on Imaging of Anticancer Drugs Induced Cardiac Toxicity

Setia,

Challa,

Vallamkonda

et al. 2024

Nanotheranostics

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“…The application of nanotheranostics to drug delivery has several benefits, including in vivo imaging, combinatory therapy, systemic controlled release, synergistic multimodality therapies, stimuli-responsive release, etc. 35 , 36 . When it comes to the translational examination of the safety and therapeutic characteristics of nanomedicines, animal models implemented in living creatures play an extremely important function 37 .…”

Section: Introductionmentioning

confidence: 99%

Targeted Nanotheranostics: Integration of Preclinical MRI and CT in the Molecular Imaging and Therapy of Advanced Diseases

Bonlawar,

Setia,

Challa

et al. 2024

Nanotheranostics

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The integration of preclinical magnetic resonance imaging (MRI) and computed tomography (CT) methods has significantly enhanced the area of therapy and imaging of targeted nanomedicine. Nanotheranostics, which make use of nanoparticles, are a significant advancement in MRI and CT imaging. In addition to giving high-resolution anatomical features and functional information simultaneously, these multifunctional agents improve contrast when used. In addition to enabling early disease detection, precise localization, and personalised therapy monitoring, they also enable early disease detection. Fusion of MRI and CT enables precise in vivo tracking of drug-loaded nanoparticles. MRI, which provides real-time monitoring of nanoparticle distribution, accumulation, and release at the cellular and tissue levels, can be used to assess the efficacy of drug delivery systems. The precise localization of nanoparticles within the body is achievable through the use of CT imaging. This technique enhances the capabilities of MRI by providing high-resolution anatomical information. CT also allows for quantitative measurements of nanoparticle concentration, which is essential for evaluating the pharmacokinetics and biodistribution of nanomedicine. In this article, we emphasize the integration of preclinical MRI and CT into molecular imaging and therapy for advanced diseases.

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“…Herbal research has been revolutionised by multifunctional preparations called "Theranostics" that combine herbal chemicals with multimodal imaging. Several people in the scientific community are interested in finding novel nanotheranostics 19 , 20 . The subject of theranostics nanomedicine is still in its early stages, but multimodal preparations combining phytochemicals with diagnostic agents have the potential to become NPs with magical properties and multiple uses 21 - 23 .…”

Section: Introductionmentioning

confidence: 99%

Herbal Theranostics: Controlled, Targeted Delivery and Imaging of Herbal Molecules

Setia,

Vallamkonda,

Challa

et al. 2024

Nanotheranostics

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Modern medicine relies on a small number of key biologics, which can be found in nature but require further characterization and purification before they can be used. Since the herbal remedy is given through a dated and ineffective method of drug administration, its effectiveness is diminished. The novel form of medicine delivery has the potential to increase the effectiveness of herbal substances while decreasing their side effects. This is the main idea behind utilising different ways of drug delivery in herbal treatments. Several benefits arise from novel formulations of herbal compounds as compared to their conventional counterparts. These include enhanced penetrating ability into tissues, constant delivery of effective doses, and resistance to physical and chemical degradation. Controlled and targeted delivery that include herbal components allow for more traditional dosing while simultaneously increasing their efficacy. Enhancing the biodistribution and target site accumulation of systemically administered herbal medicines is the goal of nanomedicine formulations. The field of nanotheranostics has made significant advancements in the development of herbal compounds by combining diagnostic and therapeutic functions on a single nanoscale platform. It is critically important to create a theranostic nanoplatform that is derived from plants and is intrinsically "all-in-one" for single molecules. In addition to examining the mechanistic approach to nanoparticle synthesis, this review highlights the therapeutic effects of nanoscale phytochemical delivery systems. Furthermore, we have evaluated the scope for future advancements in this field, discussed several nanoparticles that have been developed recently for herbal imaging, and provided experimental evidence that supports their usage.

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Nanotheranostics: Molecular Diagnostics and Nanotherapeutic Evaluation by Photoacoustic/Ultrasound Imaging in Small Animals

Cited by 6 publications

References 168 publications

Nanomedicine And Nanotheranostics: Special Focus on Imaging of Anticancer Drugs Induced Cardiac Toxicity

Nanomedicine And Nanotheranostics: Special Focus on Imaging of Anticancer Drugs Induced Cardiac Toxicity

Targeted Nanotheranostics: Integration of Preclinical MRI and CT in the Molecular Imaging and Therapy of Advanced Diseases

Herbal Theranostics: Controlled, Targeted Delivery and Imaging of Herbal Molecules

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