Nanotechnology, nanomedicine, and the development of new, effective therapies for cancer

Kawasaki, Ernest S.; Player, Audrey

doi:10.1016/j.nano.2005.03.002

Cited by 322 publications

(157 citation statements)

References 90 publications

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“…Nanomedicine is the application of nano technology to medicine, and the exploitation of nanoplatforms for cancer treatment holds great promise [8] due to the possibility of tai loring the synthesis of nanoparticles (NPs) in order to produce particles with narrow size distributions and cavities where drugs can be incorporated [9,10]. To date, there is a lot of evidence that these nanocarrier materials are capable of improving the efficiency of thera peutics through wellestablished targeted drug delivery (TDD) techniques [11].…”

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confidence: 99%

Targeted Delivery of Silver Nanoparticles and Alisertib: In Vitro and In Vivo Synergistic Effect Against Glioblastoma

et al. 2014

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Aim: Targeted biocompatible nanoplatforms presenting multiple therapeutic functions have great potential for the treatment of cancer. Materials & methods: Multifunctional nanocomposites formed by polymeric nanoparticles (PNPs) containing two cytotoxic agents -the drug alisertib and silver nanoparticles -were synthesized. These PNPs have been conjugated with a chlorotoxin, an active targeting 36-amino acid-long peptide that specifically binds to MMP-2, a receptor overexpressed by brain cancer cells. Results:The individual and synergistic activity of these two cytotoxic agents against glioblastoma multiforme was tested both in vitro and in vivo. The induced cytotoxicity in a human glioblastoma-astrocytoma epithelial-like cell line (U87MG) was studied in vitro through a trypan blue exclusion test after 48 and 72 h of exposure. Subsequently, the PNPs' biodistribution in healthy animals and their effect on tumor reduction in tumor-bearing mice were studied using PNPs radiolabeled with 99m Tc. Conclusion: Tumor reduction was achieved in vivo when using silver/alisertib@PNPs-chlorotoxin.

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confidence: 99%

Targeted Delivery of Silver Nanoparticles and Alisertib: In Vitro and In Vivo Synergistic Effect Against Glioblastoma

et al. 2014

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“…7 Using different surface modification, nanoparticles can be used as targeted delivery vehicles to carry chemotherapeutic agents or radiosensitizers to malignant cells. 8 Nanoparticles are widely used to treat cancer. For instance, Abraxane (Abraxis Bioscience) uses nanoscaled particles of albumin to bind paclitaxel.…”

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confidence: 99%

Enhanced radiation sensitivity in prostate cancer by gold-nanoparticles

Zhang

Jin²,

Chen³

et al. 2008

CIM

144

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Clin Invest Med 2008; 31 (3): E160-E167. AbstractPurpose: Nanotechnology is an emerging field with significant translational potential in medicine. In this study, we applied gold nanoparticles (GNP) to enhance radiation sensitivity and growth inhibition in radiation-resistant human prostate cancer cells. Methods: Gold nanoparticles (GNPs) were synthesized using HAuCl4 as the gold particle source and NaBH4 as the reductant. Either thio-glucose or sodium citrate was then added to the solution separately to bind the GNPs to form thio-glucose-capped gold nanoparticles (Glu-GNP) and neutral gold nanoparticles (TGS-GNPs). Human prostate carcinoma DU-145 cells were exposed to vehicle, irradiation, 15nM TGS-GNPs, or 15nM Glu-GNPs, or GNPs plus irradiation. The uptake assays of GNP were performed using hemocytometer to count cells and the mass spectrometry was applied to calculate gold mass. The cytotoxicity induced by GNPs, irradiation, or GNPs plus irradiation was measured using a standard colorimetric MTT assay. Results: Exposure to Glu-GNPs resulted in a three times increase of nanoparticle uptake compared to that of TGSGNPs in each target cell (p<0.005). Cytoplasmic intracellular uptake of both TGS-GNPs and Glu-GNPs resulted in a growth inhibition by 30.57% and 45.97% respectively, comparing to 15.88% induced by irradiation alone, in prostate cancer cells after exposure to the irradiation. GluGNPs showed a greater enhancement, 1.5 to 2 fold increases within 72 hours, on irradiation cytotoxicity compared to TGS-GNPs. Tumour killing, however, did not appear to correlate linearly with nanoparticle uptake concentrations. Conclusion: These results showed that functional glucosebound gold nanoparticles enhanced radiation sensitivity and toxicity in prostate cancer cells. In vivo studies will be followed to verify our research findings.ORIGINAL RESEARCH

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“…For example, huge improvements have been made in developing many new anti-angiogenesis medicies have been developed [1][2][3][4][5] or nano technology has been involved in developing more selective medicines for cancer patients. [6][7][8][9][10][11][12] . However, the outcomes are not as predicted.…”

Section: Introductionmentioning

confidence: 99%

How Human Lung Adenocarcinoma Cells React Towards Long-term Metabolic Stress; A Follow Up

Nakhjavani¹,

Shirazi²

2017

IJPER

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Introduction: A key challenge in fighting against cancer is cancer recurrence and resistance. Apart from the advances in the field of cancer treatment, the outcome is not still as high as expected. This may be partly due to the poor understanding about the true biology of a tumour. Tumour is a complex tissue and cells in its central parts bear nutrition deficiency and poor angiogenesis. Objective: The main aim of this study was to investigate the effect of long-term serum starvation on an in vitro model of human lung adenocarcinoma, A549 cell line. Methods: The cells bore serum starvation for 6 days and at 24-hour intervals, their proliferation, size, mitochondrial function and protein content was studied. Also, at 24-hour intervals and following at least 1 day of starvation, the cells were released in a 10% serum supplemented media and their reactions were studied as above. Results: The results demonstrated that despite the harsh conditions around the starved cells, they still proliferate and show increased mitochondrial function and protein content. Upon re-exposure to favourable conditions, this increase is more obvious. These observations were not recorded in control cells. Conclusion: It was concluded that following a long-term metabolic stress, these cells do not die, but become stronger and that can be a plausible explanation behind the difficulty in treatment of recurrent cancers.

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Nanotechnology, nanomedicine, and the development of new, effective therapies for cancer

Cited by 322 publications

References 90 publications

Targeted Delivery of Silver Nanoparticles and Alisertib: In Vitro and In Vivo Synergistic Effect Against Glioblastoma

Targeted Delivery of Silver Nanoparticles and Alisertib: In Vitro and In Vivo Synergistic Effect Against Glioblastoma

Enhanced radiation sensitivity in prostate cancer by gold-nanoparticles

How Human Lung Adenocarcinoma Cells React Towards Long-term Metabolic Stress; A Follow Up

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