Nanotechnology

Ingle, Avinash P.; Golińska, Patrycja; Yadav, Alka; Razzaghi‐Abyaneh, Mehdi; Patel, Mrunali R.; Patel, Rashmin B.; Plekhanova, Yu. V.; Решетилов, А. Н.; Rai, Mahendra

doi:10.1002/9781119671732.ch1

Cited by 4 publications

(2 citation statements)

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“…Theranostic imaging is a rapidly growing medical field driven by advances in various fields of materials science, synthetic chemistry, and molecular imaging. The term "theranostics" describes the fusion of diagnosis and treatment 4 , 5 . In the field of nanomedicine, the term theranostics is used to refer treatment where imaging agents and therapeutic molecules are co-loaded in a single nanoparticle.…”

Section: Application Of Iron Oxide Nanoparticles In Disease Diagnosis...mentioning

confidence: 99%

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Magnetic Resonance Imaging and Iron-oxide Nanoparticles in the era of Personalized Medicine

Rahman

2023

Nanotheranostics

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Medical imaging is an important factor for diagnosis. It can be used to diagnose patients, differentiate disease stages, and monitor treatment regimens. Although different imaging technologies are available, MRI is sensitive over other imaging modalities as it is capable of deep tissue penetration allowing to image the anatomical, structural, and molecular level of diseased organs. Thus, it can be used as screening tool for disease staging. One of the important components of imaging is contrast agents which are used to increase the sensitivity of MRI technology. While different types of contrast agents are available, iron-oxide based nanoparticles (IONPS) are widely used as these are easy to formulate, functionalize, biocompatible and cost effective. In addition to its use as contrast agents, these have been used as drug carriers for the treatment of different types of diseases ranging from cancer, cardiovascular diseases, neurological disorders, autoimmune diseases, and infectious diseases. For the last two decades, there has been advancement in nanotheranostics, where IONPs are formulated to carry drug and be used as contrast agents in one system so that these can be used for image-guided therapy and monitor real-life treatment response in diseased tissue. This technology can be used to stratify patients into responders and non-responders and reduce adverse drug toxicity and lead to a tailored treatment. However, success of nanotheranostics depends on several factor, including identification of disease associated biomarkers that can be targeted on IONPs during formulation. While many challenges exist for the clinical translation of nanotheranostics, it still has the potential to be implemented in personalized treatment strategy. In this review article, we discussed the use of MRI technology and IONPs in relation to their application in disease diagnosis and nanotheranostics application in personalized medicine.

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Section: Application Of Iron Oxide Nanoparticles In Disease Diagnosis...mentioning

confidence: 99%

“…Imaging additionally plays an important role in monitoring, follow-up planning, and targeting of non-invasive treatment regimens in patient-tailored manner. This is expected to bring changes in clinical practice, research and for future professionals of the imaging community 4 , 5 .…”

Section: Introductionmentioning

confidence: 99%