Nanotechnology in the Treatment of Diabetic Complications: A Comprehensive Narrative Review

He, Yujing; Al-Mureish, Abdulrahman; Wu, Na

doi:10.1155/2021/6612063

Cited by 27 publications

(24 citation statements)

References 60 publications

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“…Nanotechnology is widely employed in the treatment of diabetic retinopathy (DR) and has progressed to a new stage, where it is being used in clinical practice. With a rising number of diabetic patients, diabetic retinopathy (DR) has become the leading cause of blindness in those aged 16 to 64 [24]. Diabetes predisposing factors are quite complicated, including hypertension, hereditary factors, and so on.…”

Section: Effect Of Nanoparticles On the Occurrence Of Complications C...mentioning

confidence: 99%

Nanoparticles application as a therapeutic strategy for diabetes mellitus management

Ojo¹,

Oni²,

Rotimi³

et al. 2022

Ukr.Biochem.J.

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The prevalence of diabetes, as reported by the World Health Organization and the International Diabetes Federation, has raised many eyebrows about the dangers of diabetes mellitus to society, leading to the development of various therapeutic techniques, including nanotechnological, in the management of this disease. This review discusses silver, gold, ceramic, alloy, magnetic, silica, polymeric nanoparticles and their various applications in diabetes management which may help to reduce the incidence of diabetes and its complication.

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Section: Effect Of Nanoparticles On the Occurrence Of Complications C...mentioning

confidence: 99%

Nanoparticles application as a therapeutic strategy for diabetes mellitus management

Ojo¹,

Oni²,

Rotimi³

et al. 2022

Ukr.Biochem.J.

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show abstract

“…Nanotechnology has been particularly important in the diagnosis and treatment of diabetes in the past few years. It also has a clear track record for detecting and treating diabetic complications [4] .…”

Section: Introductionmentioning

confidence: 99%

Anti-Diabetic Activity of Silver Nanoparticles Synthesized from the Hydroethanolic Extract of Myristica fragrans Seeds

Perumalsamy

Krishnadhas

2022

Appl Biochem Biotechnol

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Myristica fragrans, also known as nutmeg is a spice that cures various diseases. This study aimed to synthesize silver nanoparticles from a hydroethanolic extract of Myristica fragrans seeds (MFHE) and evaluate their anti-diabetic properties. To MFHE, AgNO 3 solution was added and exposed to sunlight to produce silver nanoparticles from hydroethanolic seed extract of Myristica fragrans (MFHENP). The MFHENP was characterized by numerous techniques. UV-visible spectroscopy con rmed the formation of silver nanoparticles by the absorption peak at 430nm. Scanning electron microscopy (SEM) studies revealed the shape and size of the particles at the range of 50-60nm. Energy-dispersive X-ray spectroscopy (EDX) disclosed the presence of silver ions. X-ray diffraction spectrum con rmed the crystalline nature of silver nanoparticles by the peak at 39 o . FTIR analysis revealed the functional groups present in MFHE as well as in MFHENP and Zeta potential analysis was found to be 14mV. Furthermore, in-vitro anti-diabetic activity was investigated. MFHENP showed signi cant e ciency against the inhibition of alpha-amylase and alpha-glucosidase enzymes and also MFHENP retarded the glucose transport across the membrane which is analyzed by glucose diffusion and glucose uptake assays.Acarbose is used as a standard for all these methods and MFHENP e ciency proves their therapeutic potential for the treatment of diabetes mellitus.

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“…One of the highly recommended drug delivery systems, nanoemulsion, consists of oil, surfactant, and water in relevant ratios. Nanoemulsion bears an average atom size of 1–100 nm ( 68 ). These are widely used ( 88 ).…”

Section: Novel Approaches For Targeting the Dorsal Root Ganglion In M...mentioning

confidence: 99%

“…Hence, incorporating them into nanocarriers greatly enhanced their efficacy and reduced their toxicity. In addition, many side effects were accounted for with traditional treatment such as lack of specificity and adverse effects such as light-headedness, languidness, and multiple daily doses ( 68 ). The latest treatments do not provide adequate pain relief for about half of the patients and offer many undesired side effects such as somnolence and dizziness and the requirement of a complex dose regimen to reduce patient compliance.…”

Section: Introductionmentioning

confidence: 99%

Novel Nanotechnological Approaches for Targeting Dorsal Root Ganglion (DRG) in Mitigating Diabetic Neuropathic Pain (DNP)

2022

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Diabetic neuropathy is the most entrenched complication of diabetes. Usually, it affects the distal foot and toes, which then gradually approaches the lower part of the legs. Diabetic foot ulcer (DFU) could be one of the worst complications of diabetes mellitus. Long-term diabetes leads to hyperglycemia, which is the utmost contributor to neuropathic pain. Hyperglycemia causing an upregulation of voltage-gated sodium channels in the dorsal root ganglion (DRG) was often observed in models of neuropathic pain. DRG opening frequency increases intracellular sodium ion levels, which further causes increased calcium channel opening and stimulates other pathways leading to diabetic peripheral neuropathy (DPN). Currently, pain due to diabetic neuropathy is managed via antidepressants, opioids, gamma-aminobutyric acid (GABA) analogs, and topical agents such as capsaicin. Despite the availability of various treatment strategies, the percentage of patients achieving adequate pain relief remains low. Many factors contribute to this condition, such as lack of specificity and adverse effects such as light-headedness, languidness, and multiple daily doses. Therefore, nanotechnology outperforms in every aspect, providing several benefits compared to traditional therapy such as site-specific and targeted drug delivery. Nanotechnology is the branch of science that deals with the development of nanoscale materials and products, even smaller than 100 nm. Carriers can improve their efficacy with reduced side effects by incorporating drugs into the novel delivery systems. Thus, the utilization of nanotechnological approaches such as nanoparticles, polymeric nanoparticles, inorganic nanoparticles, lipid nanoparticles, gene therapy (siRNA and miRNA), and extracellular vesicles can extensively contribute to relieving neuropathic pain.

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Nanotechnology in the Treatment of Diabetic Complications: A Comprehensive Narrative Review

Cited by 27 publications

References 60 publications

Nanoparticles application as a therapeutic strategy for diabetes mellitus management

Nanoparticles application as a therapeutic strategy for diabetes mellitus management

Anti-Diabetic Activity of Silver Nanoparticles Synthesized from the Hydroethanolic Extract of Myristica fragrans Seeds

Novel Nanotechnological Approaches for Targeting Dorsal Root Ganglion (DRG) in Mitigating Diabetic Neuropathic Pain (DNP)

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