Nanotechnology in Cancer Medicine

Grossman, Jennifer; McNeil, Scott E.

doi:10.1063/pt.3.1678

Cited by 134 publications

(101 citation statements)

References 18 publications

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“…For the calculation the thermochemical cycle is used [17]. It includes the following steps: 1) LPAAm + H 2 O (excess) = LPAAm dilute solution + ΔH 1 2) FeOx + H 2 O (excess) = FeOx ferrofluid + ΔH 2 3) LPAAm/FeOx + H 2 O (excess) = = LPAAm solution in ferrofluid + ΔH 3 4) LPAAm solution + ferrofluid = = LPAAm solution in ferrofluid + ΔH 4 Combination of these steps gives the following equation for the formation of the composite from the components:…”

Section: Results and Their Discussionmentioning

confidence: 99%

“…Considering the practical application in biomedicine and bioengineering it is important to ensure well controlled shape of iron oxide particles and a large single batch of their production. The fabrication techniques providing enhanced batch sizes [4,5] attract special attention as the properties of MNPs can vary from batch to batch. One of the methods of MNPs synthesis providing a high production rate is the physical method of the laser target evaporation (LTE) [6][7][8][9]: it provides 10 to 50 nm spherical MNPs at ca.…”

Section: Introductionmentioning

confidence: 99%

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Interaction of iron oxide nanoparticles synthesized by laser target evaporation with polyacrylamide in composites and ferrogels

2017

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Iron oxide magnetic nanoparticles (MNPs) with average diameter 11.7 nm synthesized by laser target evaporation were used for the synthesis of composites and ferrogels based on polyacrylamide network. The chemical composition of MNPs corresponded to maghemite. It was shown that intact MNPs strongly interacted with polyacrylamide polymeric network, while the adsorption of electrostatic stabilizer on the surface of MNPs efficiently prevents such interaction. Synthesis of ferrogels was performed by the radical polymerization of acrylamide in electrostatically stabilized suspensions of MNPs in water. It was shown that the molecular structure, water uptake, and compression modulus can be controlled by the concentration of monomer taken in the synthesis.

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Section: Results and Their Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Interaction of iron oxide nanoparticles synthesized by laser target evaporation with polyacrylamide in composites and ferrogels

2017

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“…This would open the way to design the methodology for closing the gap in free energy of cancer cell. We propose Nano technology as a reasonable way for delivery of necessary modifying measures such as nanotubes with inherent vibratory potential to the site of action (Caraglia et al, 2012;Grossman and McNeil, 2012;Medhe et al, 2013). We also suggest that it is critically important to identify the exact location of the pathological lesion inside the cell.…”

Section: Discussionmentioning

confidence: 99%

Free Energy Measurement Distinguishes Normal From Cancer Cell, Offering a New Perspective for Curing Cancer

Afrasiabi

Melekh-Shalom

2013

OnLine Journal of Biological Sciences

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The interplay of the second law of thermodynamics with the normal state and the methodology needed for the measurement of free energy of normal and malignant cells and its practical implications has not been clearly addressed in current literature. The second law of thermodynamics is one of the most fundamental laws governing the known universe at all levels. A normal cell has an exceptional ability to minimize the speed of rise in entropy to saturation of the limits of the second law. By virtue of this law, any normal resting cell is at a maximum allowable free energy. In this regard mitosis could be viewed as an attempt to maximize the lowered cellular free energy. Here we present the result of our first series of measurements, which show a significant measurable difference between the free energy of normal and malignant cells using an Olympus 510 Argon laser to calculate a diffusion correlation as well as direct visualization of motion of malignant and normal cells cultured overnight in collagen mesh. We found a significantly higher vibratory motion of the normal cells after correction for confounding factors. We also propose a new way to increase the free energy of the malignant cell to match that of its normal counterpart. This could offer hope for cure by conversion of distorted energetics of the malignant cell.

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“…The altered lymphatic drainage of the tumor contributes to this effect [15]. This type of passive targeting is known as "EPR" (enhanced permeation and retention) [16,17] (Fig. 1).…”

Section: Passive Targeting By Nanoparticlesmentioning

confidence: 99%

Nanotechnology in Cancer Diagnosis and Treatment

El-Karim¹,

El-Zahar²,

Anwar³

2015

JPP

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Nanotechnology refers to research and technology development at the atomic, molecular, and macromolecular scale, leading to the controlled manipulation and study of structures and devices with length scales in the 1-100 nanometers range. Objects at this scale, such as "nanoparticles," take on novel properties and functions that differ markedly from those seen in the bulk scale. The small size, surface tailor ability, improved solubility, and multifunctional of nanoparticles open many new research avenues for biologists. Nanoparticles are classified into inorganic nanoparticles such as gold nanoparticles and organic nanoparticles such as carbon nanotubes and dendrimers. Different types of nanoparticals such as nanocrystals, liposomes, polymeric nanoparticles, dendrimers, quantum dots and superparamagnetic nanoparticles illustrated different examples of promising nanoparticles for cancer treatment and imaging.

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Nanotechnology in Cancer Medicine

Abstract: Because of a previously unexploited weakness in tumor architecture, nanomaterials may offer a way to treat cancer without doing too much damage to healthy tissue. The weakness isn’t really a property of the tumors themselves but of the blood vessels that feed them.

Cited by 134 publications

References 18 publications

Interaction of iron oxide nanoparticles synthesized by laser target evaporation with polyacrylamide in composites and ferrogels

Interaction of iron oxide nanoparticles synthesized by laser target evaporation with polyacrylamide in composites and ferrogels

Free Energy Measurement Distinguishes Normal From Cancer Cell, Offering a New Perspective for Curing Cancer

Nanotechnology in Cancer Diagnosis and Treatment

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