Nanotechnology for tissue engineering: Need, techniques and applications

Kingsley, J. Danie; Ranjan, Shivendu; Dasgupta, Nandita; Saha, Proud

doi:10.1016/j.jopr.2013.02.021

Cited by 67 publications

(39 citation statements)

References 40 publications

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“…The growth factors attached onto nanofibers through heparin were advantageous as compared with absorbed growth factor. The heparin conjugated scaffold with bFGF and EGF helps to preserve their bioactivity and increase their half‐life and also significantly promotes neural differentiation and axon growth for neural tissue regeneration . In addition to physical cues and macromolecular cues, chemical cues were also studied for their role in cellular activity of stem cells.…”

Section: Nanotechnology For Stem Cellsmentioning

confidence: 99%

“…The heparin conjugated scaffold with bFGF and EGF helps to preserve their bioactivity and increase their half-life and also significantly promotes neural differentiation and axon growth for neural tissue regeneration. [117,118] In addition to physical cues and macromolecular cues, chemical cues were also studied for their role in cellular activity of stem cells. For example, Li et al demonstrated that positively (amine) charged gold nanoparticles (AuNPs) increased proliferation of hMSCs with increased expression of FGF-2 in comparison with negatively (COOH) charged AuNPs.…”

Section: Nanotechnology and Stem Cell Microenvironmentmentioning

confidence: 99%

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Engineering Concepts in Stem Cell Research

Narayanan

Mishra

Singh

et al. 2017

Biotechnology Journal

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The field of regenerative medicine integrates advancements made in stem cells, molecular biology, engineering, and clinical methodologies. Stem cells serve as a fundamental ingredient for therapeutic application in regenerative medicine. Apart from stem cells, engineering concepts have equally contributed to the success of stem cell based applications in improving human health. The purpose of various engineering methodologies is to develop regenerative and preventive medicine to combat various diseases and deformities. Explosion of stem cell discoveries and their implementation in clinical setting warrants new engineering concepts and new biomaterials. Biomaterials, microfluidics, and nanotechnology are the major engineering concepts used for the implementation of stem cells in regenerative medicine. Many of these engineering technologies target the specific niche of the cell for better functional capability. Controlling the niche is the key for various developmental activities leading to organogenesis and tissue homeostasis. Biomimetic understanding not only helped to improve the design of the matrices or scaffolds by incorporating suitable biological and physical components, but also ultimately aided adoption of designs that helped these materials/devices have better function. Adoption of engineering concepts in stem cell research improved overall achievement, however, several important issues such as long-term effects with respect to systems biology needs to be addressed. Here, in this review the authors will highlight some interesting breakthroughs in stem cell biology that use engineering methodologies.

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Section: Nanotechnology For Stem Cellsmentioning

confidence: 99%

Section: Nanotechnology and Stem Cell Microenvironmentmentioning

confidence: 99%

Engineering Concepts in Stem Cell Research

Narayanan

Mishra

Singh

et al. 2017

Biotechnology Journal

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“…These shortcomings led to evolution of a new field of TE. With the advancement of TE, it was aimed to develop 3‐D scaffolds or such biomaterials that should mimic the natural extracellular matrix (ECM) of tissues so that the cells could easily attach and proliferate to regain the normal function after being seeded onto these TE biomaterials . TE deals with combination of organ transplantation, material science, and engineering discipline which aided in development of regenerative medicines .…”

Section: Introductionmentioning

confidence: 99%

“…With the advancement of TE, it was aimed to develop 3-D scaffolds or such biomaterials that should mimic the natural extracellular matrix (ECM) of tissues so that the cells could easily attach and proliferate to regain the normal function after being seeded onto these TE biomaterials. 4 TE deals with combination of organ transplantation, material science, and engineering discipline which aided in development of regenerative medicines. 5 In view of all these advancements, there is still need for synthesis of better materials as the typical scaffolds that were proposed to mimic the natural environment have some limitations such as these are not biocompatible, have low mechanical strength and these do not provide proper vascularization required for the growing cells.…”

Section: Introductionmentioning

confidence: 99%

Nanomaterials as potential and versatile platform for next generation tissue engineering applications

et al. 2019

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Tissue engineering (TE) is an emerging field where alternate/artificial tissues or organ substitutes are implanted to mimic the functionality of damaged or injured tissues. Earlier efforts were made to develop natural, synthetic, or semisynthetic materials for skin equivalents to treat burns or skin wounds. Nowadays, many more tissues like bone, cardiac, cartilage, heart, liver, cornea, blood vessels, and so forth are being engineered using 3‐D biomaterial constructs or scaffolds that could deliver active molecules such as peptides or growth factors. Nanomaterials (NMs) due to their unique mechanical, electrical, and optical properties possess significant opportunities in TE applications. Traditional TE scaffolds were based on hydrolytically degradable macroporous materials, whereas current approaches emphasize on controlling cell behaviors and tissue formation by nano‐scale topography that closely mimics the natural extracellular matrix. This review article gives a comprehensive outlook of different organ specific NMs which are being used for diversified TE applications. Varieties of NMs are known to serve as biological alternatives to repair or replace a portion or whole of the nonfunctional or damaged tissue. NMs may promote greater amounts of specific interactions stimulated at the cellular level, ultimately leading to more efficient new tissue formation. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2433–2449, 2019.

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“…Of this diverse precinct, tissue engineering and nanotechnology plays an elemental role, as these two study areas have revolutionised current therapies to repair, replace cells, tissues and organs with the aid of various active molecules [1].…”

Section: Introductionmentioning

confidence: 99%

Autologous Gene Therapy - A Proactive Approach to Cancer Critique

Ahmad¹

2014

J Cancer Sci Ther

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Gene therapy has a vast range of applications not only restricted to AbstractCancer is one of the most prevalent diseases that affect the major population with each year the frequency is increasing exponentially. Patients with diagnosed cancer are generally treated with the conventional therapies like radiation therapy, chemotherapy. However the survival rate and the life span are known to prolonged, these therapies are quite problematic let alone their detrimental side effects. Gene therapy on the other hand is quite promising since the body's immune response is not compromised while targeting the cancerous cell. While getting further insights into the complex pathways and mechanisms associated with the development of malignant cells has led to the identification more sophisticated and specified cancer therapies, it nevertheless remains imperative to execute the conventional therapies and the associated anticancer drug molecules. Various characteristic features like less toxicity and ability to induce an immune response make the therapy quite probable for various cancers like pancreatic, ovarian and Glioblastoma. Based on the results obtained from pre-clinical studies in model animals, it has set stage for the commercialization of the human trials. The advantages associated with this therapy for the treatment has started attracting focus to further modify and optimize the procedures for better results.

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Nanotechnology for tissue engineering: Need, techniques and applications

Cited by 67 publications

References 40 publications

Engineering Concepts in Stem Cell Research

Engineering Concepts in Stem Cell Research

Nanomaterials as potential and versatile platform for next generation tissue engineering applications

Autologous Gene Therapy - A Proactive Approach to Cancer Critique

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