Nanotechnology for the Detection and Therapy of Stroke

Kyle, Stuart; Saha, Sikha

doi:10.1002/adhm.201400009

Cited by 62 publications

(48 citation statements)

References 184 publications

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“…CTX is a small peptide that has passed rigorous preclinical safety tests and entered a phase I clinical trials 40 . Therefore, it is likely that, compared to most other formulations previously reported 41 , PLGA-CTX/LEX NPs reported in this study have a more favorable safety profile. We evaluated the interaction of PLGA-CTX/LEX NPs with erythrocytes and found they did not show detectable hemolysis effects at the tested doses (Figure S3).…”

Section: Discussionmentioning

confidence: 82%

Targeted drug delivery to ischemic stroke via chlorotoxin-anchored, lexiscan-loaded nanoparticles

Han

Cai

Tian

et al. 2016

Nanomedicine: Nanotechnology, Biology and Medicine

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Ischemic stroke is a leading cause of disability and death worldwide. Current drug treatment for stroke remains inadequate due to the existence of the blood-brain barrier. We proposed an innovative nanotechnology-based autocatalytic targeting approach, in which the blood-brain barrier modulator lexiscan is encapsulated in nanoparticles to enhance blood-brain barrier permeability and autocatalytically augment the brain stroke-targeting delivery efficiency of chlorotoxin-anchored nanoparticles. The nanoparticles efficiently and specifically accumulated in the brain ischemic microenvironment and the targeting efficiency autocatalytically increased with subsequent administrations. When Nogo-66 receptor antagonist peptide NEP1-40, a potential therapeutic agent for ischemic stroke, was loaded, nanoparticles significantly reduced infarct volumes and enhanced survival. Our findings suggest that the autocatalytic targeting approach is a promising strategy for drug delivery to the ischemic microenvironment inside the brain. Nanoparticles developed in this study may serve as a new approach for the clinical management of stroke.

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Section: Discussionmentioning

confidence: 82%

Targeted drug delivery to ischemic stroke via chlorotoxin-anchored, lexiscan-loaded nanoparticles

Han

Cai

Tian

et al. 2016

Nanomedicine: Nanotechnology, Biology and Medicine

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“…CNTs are electrically and thermally conductive and have ultralight weight. They are highly flexible, very strong, and inert but can undergo chemical modification with various functional groups depending on their intended use [8][9][10]. CNTs structural backbone consists of carbon atoms which exhibit thermal and electronic conductivity including great strength.…”

Section: Carbon Nanotubes In the Diagnosis And Treatment Of Central Nmentioning

confidence: 99%

“…It is a cerebrovascular disorder whereby the brain is deprived of oxygen, nutrients, and glucose as a result of obstruction of the vessels supplying the brain [8,9]. Symptoms are usually sudden, within seconds to hours, and can include unilateral weakness or numbness of the face, arms, or legs, aphasia, visual impairment, dysarthria, confusion, loss of balance and coordination, difficulty with walking, and, in severe cases, even death.…”

Section: Introductionmentioning

confidence: 99%

Diagnosis and Treatment of Neurological and Ischemic Disorders Employing Carbon Nanotube Technology

Komane

Choonara

Toit

et al. 2016

Journal of Nanomaterials

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Extensive research on carbon nanotubes has been conducted due to their excellent physicochemical properties. Based on their outstanding physicochemical properties, carbon nanotubes have the potential to be employed as theranostic tools for neurological pathologies such as Alzheimer’s disease and Parkinson’s disease including ischemic stroke diagnosis and treatment. Stroke is currently regarded as the third root cause of death and the leading source of immobility around the globe. The development and improvement of efficient and effective procedures for central nervous system disease diagnosis and treatment is necessitated. The main aim of this review is to discuss the application of nanotechnology, specifically carbon nanotubes, to the diagnosis and treatment of neurological disorders with an emphasis on ischemic stroke. Areas covered include the conventional current diagnosis and treatment of neurological disorders, as well as a critical review of the application of carbon nanotubes in the diagnosis and treatment of ischemic stroke, covering areas such as functionalization of carbon nanotubes and carbon nanotube-based biosensors. A broad perspective on carbon nanotube stimuli-responsiveness, carbon nanotube toxicity, and commercially available carbon nanotubes is provided. Potential future studies employing carbon nanotubes have been discussed, evaluating their extent of advancement in the diagnosis and treatment of neurological and ischemic disorders.

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“…Remarkable developments in physics and chemistry provide novel opportunities to collect and convert chemical information into signals that can be detected through convenient modalities: optical (e.g., from quantum dots), electrical (e.g., from carbon nanotubes) or magnetic (e.g., from iron oxide nanoparticles) …”

Section: Sensors To Acquire Chemical Informationmentioning

confidence: 99%

Fusing Sensor Paradigms to Acquire Chemical Information: An Integrative Role for Smart Biopolymeric Hydrogels

Kim

Liu

Ben‐Yoav

et al. 2016

Adv Healthcare Materials

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The Information Age transformed our lives but it has had surprisingly little impact on the way chemical information (e.g., from our biological world) is acquired, analyzed and communicated. Sensor systems are poised to change this situation by providing rapid access to chemical information. This access will be enabled by technological advances from various fields: biology enables the synthesis, design and discovery of molecular recognition elements as well as the generation of cell-based signal processors; physics and chemistry are providing nano-components that facilitate the transmission and transduction of signals rich with chemical information; microfabrication is yielding sensors capable of receiving these signals through various modalities; and signal processing analysis enhances the extraction of chemical information. The authors contend that integral to the development of functional sensor systems will be materials that (i) enable the integrative and hierarchical assembly of various sensing components (for chemical recognition and signal transduction) and (ii) facilitate meaningful communication across modalities. It is suggested that stimuli-responsive self-assembling biopolymers can perform such integrative functions, and redox provides modality-spanning communication capabilities. Recent progress toward the development of electrochemical sensors to manage schizophrenia is used to illustrate the opportunities and challenges for enlisting sensors for chemical information processing.

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Nanotechnology for the Detection and Therapy of Stroke

Cited by 62 publications

References 184 publications

Targeted drug delivery to ischemic stroke via chlorotoxin-anchored, lexiscan-loaded nanoparticles

Targeted drug delivery to ischemic stroke via chlorotoxin-anchored, lexiscan-loaded nanoparticles

Diagnosis and Treatment of Neurological and Ischemic Disorders Employing Carbon Nanotube Technology

Fusing Sensor Paradigms to Acquire Chemical Information: An Integrative Role for Smart Biopolymeric Hydrogels

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