Nanotechnology for Cancer Imaging: Advances, Challenges, and Clinical                     Opportunities

Liu, Christina; Grodzinski, Piotr

doi:10.1148/rycan.2021200052

Cited by 14 publications

(8 citation statements)

References 93 publications

(92 reference statements)

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“…The use of NPs in imaging applications were discussed in some other recent reviews in details, and we refer the readers to these papers. [131][132][133][134][135]…”

Section: Imaging Using Peptide-modified Nanoparticlesmentioning

confidence: 99%

“…They performed multimodal photoacoustic microscopy (PAM) and optical coherence tomography (OCT) in 12 living rabbits to visualize newly developed blood vessels in the sub‐retinal pigment epithelium (RPE) space of the retina. The use of NPs in imaging applications were discussed in some other recent reviews in details, and we refer the readers to these papers [131–135] …”

Section: Imaging Using Peptide‐modified Nanoparticlesmentioning

confidence: 99%

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Peptide‐conjugated Nanoparticle Platforms for Targeted Delivery, Imaging, and Biosensing Applications

Ilieş,

Yildiz,

Abbas

2024

ChemBioChem

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Peptides have become an indispensable tool in engineering of multifunctional nanostructure platforms for biomedical applications such as targeted drug and gene delivery, imaging and biosensing. They can be covalently incorporated into a variety of nanoparticles (NPs) including polymers, metallic nanoparticles, and others. Using different bioconjugation techniques, multifunctional peptide‐modified NPs can be formulated to produce therapeutical and diagnostic platforms offering high specificity, lower toxicity, biocompatibility, and stimuli responsive behavior. Targeting peptides can direct the nanoparticles into specific tissues for targeted drug and gene delivery and imaging applications due to their specificity towards certain receptors. Furthermore, due to their stimuli‐responsive features, they can offer controlled release of therapeutics into desired sites of disease. In addition, peptide‐based biosensors and imaging agents can provide non‐invasive detection and monitoring of diseases including cancer, infectious diseases, and neurological disorders. In this review, we covered the design and formulation of recent peptide‐based NP platforms, as well as their utilization in in vitro and in vivo applications such as targeted drug and gene delivery, targeting, sensing, and imaging applications. In the end, we provided the future outlook to design new peptide conjugated nanomaterials for biomedical applications.

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“…The use of NPs in imaging applications were discussed in some other recent reviews in details, and we refer the readers to these papers. [131][132][133][134][135]…”

Section: Imaging Using Peptide-modified Nanoparticlesmentioning

confidence: 99%

Section: Imaging Using Peptide‐modified Nanoparticlesmentioning

confidence: 99%

Peptide‐conjugated Nanoparticle Platforms for Targeted Delivery, Imaging, and Biosensing Applications

Ilieş,

Yildiz,

Abbas

2024

ChemBioChem

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“…It can be a good choice to solve the low bioavailability and pharmacokinetics of insoluble drugs. Nanoemulsions are prepared by combining surfactants, oils, hydrophilic solvents, and co-solvents that have the unique ability to form fine colloidal dispersions of oil in water [ 153 , 154 , 155 , 156 , 157 ]. Therefore, the use of nanotechnology offers a considerable advantage to the pharmacological potential of flavonoids, which have low solubility, rapid metabolism, and poor absorption in the gastrointestinal tract [ 156 ].…”

Section: Naringenin and Hesperidin: An Overviewmentioning

confidence: 99%

Naringenin and Hesperidin as Promising Alternatives for Prevention and Co-Adjuvant Therapy for Breast Cancer

et al. 2023

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Citrus (genus Citrus L.) fruits are essential sources of bioactive compounds with antioxidant properties, such as flavonoids. These polyphenolic compounds are divided into subclasses, in which flavanones are the most prominent. Among them, naringenin and hesperidin are emerging compounds with anticancer potential, especially for breast cancer (BC). Several mechanisms have been proposed, including the modulation of epigenetics, estrogen signaling, induction of cell death via regulation of apoptotic signaling pathways, and inhibition of tumor invasion and metastasis. However, this information is sparse in the literature and needs to be brought together to provide an overview of how naringenin and hesperidin can serve as therapeutic tools for drug development and as a successful co-adjuvant strategy against BC. This review detailed such mechanisms in this context and highlighted how naringenin and hesperidin could interfere in BC carcinogenesis and be helpful as potential alternative therapeutic sources for breast cancer treatment.

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“…And, antioxidant enzymes, miscellaneous antioxidants or vitamins E and C are used to inhibit the formation of ROS or scavenge reactive species to protect liver injury in clinical ( Galaris et al, 2006 ). However, because of the short blood circulation time and serious side effects of these drugs, the clinical effect is not good ( Liu and Grodzinski, 2021 ). In recent years, with the development of optical technology, it is gradually moving towards medicine.…”

Section: Light Therapy Based On Oxidative Stress-mediated Hirimentioning

confidence: 99%

The application of optical technology in the diagnosis and therapy of oxidative stress-mediated hepatic ischemia-reperfusion injury

Wang

Shao²,

Chen³

et al. 2023

Front. Bioeng. Biotechnol.

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Hepatic ischemia-reperfusion injury (HIRI) is defined as liver tissue damage and cell death caused by reperfusion during liver transplantation or hepatectomy. Oxidative stress is one of the important mechanisms of HIRI. Studies have shown that the incidence of HIRI is very high, however, the number of patients who can get timely and efficient treatment is small. The reason is not hard to explain that invasive ways of detection and lack of timely of diagnostic methods. Hence, a new detection method is urgently needed in clinic application. Reactive oxygen species (ROS), which are markers of oxidative stress in the liver, could be detected by optical imaging and offer timely and effective non-invasive diagnosis and monitoring. Optical imaging could become the most potential tool of diagnosis of HIRI in the future. In addition, optical technology can also be used in disease treatment. It found that optical therapy has the function of anti-oxidative stress. Consequently, it has possibility to treat HIRI caused by oxidative stress. In this review, we mainly summarized the application and prospect of optical techniques in oxidative stress-induced by HIRI.

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Nanotechnology for Cancer Imaging: Advances, Challenges, and Clinical Opportunities

Cited by 14 publications

References 93 publications

Peptide‐conjugated Nanoparticle Platforms for Targeted Delivery, Imaging, and Biosensing Applications

Peptide‐conjugated Nanoparticle Platforms for Targeted Delivery, Imaging, and Biosensing Applications

Naringenin and Hesperidin as Promising Alternatives for Prevention and Co-Adjuvant Therapy for Breast Cancer

The application of optical technology in the diagnosis and therapy of oxidative stress-mediated hepatic ischemia-reperfusion injury

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