Nanotechnology for angiogenesis: opportunities and challenges

Kargozar, Saeid; Baino, Francesco; Hamzehlou, Sepideh; Hamblin, Michael R.; Mozafari, Masoud

doi:10.1039/c8cs01021h

Cited by 141 publications

(89 citation statements)

References 533 publications

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“…Apart from these molecules, enhanced neovascularization could be achieved by adding inorganic elements (e.g., cerium and europium) to electrospun scaffolds [44][45][46]. Although there are several inorganic elements with the potential ability to induce angiogenesis, the risk of cytotoxicity and genotoxicity still limits their extensive use in tissue engineering applications [47]. In order to overcome this restriction, highly controlled doping of angiogenic elements to the structure of bioceramics (e.g., calcium phosphates and bioactive glasses) is suggested.…”

Section: Fiber Orientationmentioning

confidence: 99%

Electrospun Nanofibers for Improved Angiogenesis: Promises for Tissue Engineering Applications

et al. 2020

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Angiogenesis (or the development of new blood vessels) is a key event in tissue engineering and regenerative medicine; thus, a number of biomaterials have been developed and combined with stem cells and/or bioactive molecules to produce three-dimensional (3D) pro-angiogenic constructs. Among the various biomaterials, electrospun nanofibrous scaffolds offer great opportunities for pro-angiogenic approaches in tissue repair and regeneration. Nanofibers made of natural and synthetic polymers are often used to incorporate bioactive components (e.g., bioactive glasses (BGs)) and load biomolecules (e.g., vascular endothelial growth factor (VEGF)) that exert pro-angiogenic activity. Furthermore, seeding of specific types of stem cells (e.g., endothelial progenitor cells) onto nanofibrous scaffolds is considered as a valuable alternative for inducing angiogenesis. The effectiveness of these strategies has been extensively examined both in vitro and in vivo and the outcomes have shown promise in the reconstruction of hard and soft tissues (mainly bone and skin, respectively). However, the translational of electrospun scaffolds with pro-angiogenic molecules or cells is only at its beginning, requiring more research to prove their usefulness in the repair and regeneration of other highly-vascularized vital tissues and organs. This review will cover the latest progress in designing and developing pro-angiogenic electrospun nanofibers and evaluate their usefulness in a tissue engineering and regenerative medicine setting.

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Section: Fiber Orientationmentioning

confidence: 99%

Electrospun Nanofibers for Improved Angiogenesis: Promises for Tissue Engineering Applications

et al. 2020

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“…Angiogenic factors promote the generation of new blood vessels and increase blood flow in damaged tissue in the ischemic state. 48 Successful angiogenesis is highly dependent on delivery of vascular endothelial growth factor (VEGF) to an ischemic site.…”

Section: Liposome Applications In Medicinementioning

confidence: 99%

Liposomes: Biomedical Applications

Kim

Jeong

2021

Chonnam Med J

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Liposomes, with their flexible physicochemical and biophysical properties, continue to be studied as an important potential a critical drug delivery system. Liposomes have overcome the challenges of conventional free drug therapy by encapsulating therapeutic agents, thereby improving in vivo biodistribution and reducing systemic toxicity. New imaging modalities and interpretation techniques, as well as new techniques for targetable system formulation technique, and tumor environmental information, have affected the search for a means of overcoming the difficulties of conventional liposome formulation. In this review, we briefly discuss how liposomal formulation has been applied across the biomedical field, particularly as a therapy, and the role it may play in the future, when paired with new developments in diagnosis and theranostics. The biological challenges that still remain and the translational obstacles are discussed.

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“…The environmental pH, reactive oxygen species (ROS) generation, and intracellular oxygen concentration determine the pro- or antiangiogenic behavior of CNPs. Reproduced from [ 86 ].…”

Section: Figurementioning

confidence: 99%

Cerium Oxide Nanoparticles (Nanoceria): Hopes in Soft Tissue Engineering

et al. 2020

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Several biocompatible materials have been applied for managing soft tissue lesions; cerium oxide nanoparticles (CNPs, or nanoceria) are among the most promising candidates due to their outstanding properties, including antioxidant, anti-inflammatory, antibacterial, and angiogenic activities. Much attention should be paid to the physical properties of nanoceria, since most of its biological characteristics are directly determined by some of these relevant parameters, including the particle size and shape. Nanoceria, either in bare or functionalized forms, showed the excellent capability of accelerating the healing process of both acute and chronic wounds. The skin, heart, nervous system, and ophthalmic tissues are the main targets of nanoceria-based therapies, and the other soft tissues may also be evaluated in upcoming experimental studies. For the repair and regeneration of soft tissue damage and defects, nanoceria-incorporated film, hydrogel, and nanofibrous scaffolds have been proven to be highly suitable replacements with satisfactory outcomes. Still, some concerns have remained regarding the long-term effects of nanoceria administration for human tissues and organs, such as its clearance from the vital organs. Moreover, looking at the future, it seems necessary to design and develop three-dimensional (3D) printed scaffolds containing nanoceria for possible use in the concepts of personalized medicine.

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Nanotechnology for angiogenesis: opportunities and challenges

Abstract: The progress, opportunities, and challenges of nanotechnology-based strategies for angiogenesis inhibition, angiogenesis stimulation, theranostic and imaging purposes are summarized.

Cited by 141 publications

References 533 publications

Electrospun Nanofibers for Improved Angiogenesis: Promises for Tissue Engineering Applications

Electrospun Nanofibers for Improved Angiogenesis: Promises for Tissue Engineering Applications

Liposomes: Biomedical Applications

Cerium Oxide Nanoparticles (Nanoceria): Hopes in Soft Tissue Engineering

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