Nanotechnology Footsocks for Diabetic Foot

Piaggesi, Alberto; Iacopi, Elisabetta; Banchellini, Elisa; Nobili, Laura Ambrosini

doi:10.1201/b11775-24

Cited by 1 publication

(1 citation statement)

References 26 publications

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“…18 Recently, a biomedical application of nanotechnology (Difoprev ® system) has made it possible to design and realize an instrument which enables not only maximized moisturizing action but also the bypassing of patient compliance questions. In view of the optimal results obtained by this system in the treatment of preulcerative lesions of the shin and foot in diabetic patients, 15,16,19 and in view of the characteristics of the lesions frequently noted in elderly patients which are similar, it was decided that a test be conducted regarding the efficacy of this system also under these latter conditions (which may be defined or considered "paraphysiological"). Elderly persons, especially those who are not well off, or who are socially deprived, frequently neglect personal hygiene.…”

Section: Discussionmentioning

confidence: 99%

The Difoprev® system in treatment of the skin of the elderly: preliminary data obtained in patients with dryness and hyperkeratosis

Aluigi¹

2014

JVD

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Background: Aging brings with it a number of structural and functional modifications of the skin and adnexa, particularly in the lower extremities, which may determine a gradual reduction in elasticity, with associated functional alterations which may determine preulcerative lesions. The aim of this study was to test the efficacy of the Difoprev ® system, consisting in a sock functioning as a vehicle for microcapsules containing moisturizing agents (Pseudoalteromonas ferment extract, a glycoprotein synthesized by the bacterium, Pseudoalteromonas antarctica NF3). The system is already widely used for cutaneous treatment in cases of neuropathic diabetic foot, and in prevention/treatment of dryness and hyperkeratosis of the skin of the lower extremities in elderly persons (shin/foot). Methodology: Sixteen patients aged .70 years (group A) were treated with the Difoprev ® system for 8 weeks. This group was compared with 8 patients of the same age (group B) who wore the same type of sock without microcapsules. Following initial assessment at the time of recruitment, the patients underwent controls at 15, 30, and 60 days to assess the degree of hydration of the skin derived from an objective evaluation of degree of keratosis according to an arbitrary scale of seriousness ranging from 1 (absent) to 4 (marked). The changes were rated according to a scale ranging from 1 (no improvement) to 5 (marked improvement). A comparative study of all cases was conducted by means of photographs taken as the treatment commenced and on termination of treatment. Results: Most patients treated with Difoprev ® presented a reduction in the degree of keratosis of the skin (90%, of whom 15% had marked improvement), compared to the patients who wore only the sock with no microcapsules (10% with slight improvement). None of the patients undergoing Difoprev ® system treatment displayed signs of intolerance or untoward reactions. Conclusion: While the clinical assessment was conducted on a small number of patients, the results obtained nevertheless demonstrate that the Difoprev ® system is a safe, simple method for obtaining improvements to the skin of elderly people by reduction of the degree of keratosis through enhanced hydration.

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Section: Discussionmentioning

confidence: 99%

The Difoprev® system in treatment of the skin of the elderly: preliminary data obtained in patients with dryness and hyperkeratosis

Aluigi¹

2014

JVD

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Nanotechnology Footsocks for Diabetic Foot

Cited by 1 publication

References 26 publications

The Difoprev® system in treatment of the skin of the elderly: preliminary data obtained in patients with dryness and hyperkeratosis

The Difoprev® system in treatment of the skin of the elderly: preliminary data obtained in patients with dryness and hyperkeratosis

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Nanotechnology Footsocks for Diabetic Foot

Cited by 1 publication

References 26 publications

The Difoprev&reg; system in treatment of the skin of the elderly: preliminary data obtained in patients with dryness and hyperkeratosis

The Difoprev&reg; system in treatment of the skin of the elderly: preliminary data obtained in patients with dryness and hyperkeratosis

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The Difoprev® system in treatment of the skin of the elderly: preliminary data obtained in patients with dryness and hyperkeratosis

The Difoprev® system in treatment of the skin of the elderly: preliminary data obtained in patients with dryness and hyperkeratosis