Nanotechnology‐Based Strategies to Evaluate and Counteract Cancer Metastasis and Neoangiogenesis

Şen, Özlem; Emanet, Melis; Ciofani, Gianni

doi:10.1002/adhm.202002163

Cited by 16 publications

(15 citation statements)

References 266 publications

(417 reference statements)

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“…Wound healing, ovulation, and embryonic development, are just a few of the numerous processes in which it plays an important part. In addition, it is a crucial factor in the pathogenesis of a great number of disorders (including cancer metastasis and arthritis) [ 230 , 231 , 241 ]. Because nutrients and an appropriate oxygen supply are necessary for the survival of metastatic cells and the development of tumors, metastatic cells need to remain in close proximity to blood capillaries to maintain direct contact with the circulatory network [ 157 ].…”

Section: Pro-angiogenic Factors and Anti-angiogenic Therapy For Eradi...mentioning

confidence: 99%

Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process

et al. 2022

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Angiogenesis is a vital biological process involving blood vessels forming from pre-existing vascular systems. This process contributes to various physiological activities, including embryonic development, hair growth, ovulation, menstruation, and the repair and regeneration of damaged tissue. On the other hand, it is essential in treating a wide range of pathological diseases, such as cardiovascular and ischemic diseases, rheumatoid arthritis, malignancies, ophthalmic and retinal diseases, and other chronic conditions. These diseases and disorders are frequently treated by regulating angiogenesis by utilizing a variety of pro-angiogenic or anti-angiogenic agents or molecules by stimulating or suppressing this complicated process, respectively. Nevertheless, many traditional angiogenic therapy techniques suffer from a lack of ability to achieve the intended therapeutic impact because of various constraints. These disadvantages include limited bioavailability, drug resistance, fast elimination, increased price, nonspecificity, and adverse effects. As a result, it is an excellent time for developing various pro- and anti-angiogenic substances that might circumvent the abovementioned restrictions, followed by their efficient use in treating disorders associated with angiogenesis. In recent years, significant progress has been made in different fields of medicine and biology, including therapeutic angiogenesis. Around the world, a multitude of research groups investigated several inorganic or organic nanoparticles (NPs) that had the potential to effectively modify the angiogenesis processes by either enhancing or suppressing the process. Many studies into the processes behind NP-mediated angiogenesis are well described. In this article, we also cover the application of NPs to encourage tissue vascularization as well as their angiogenic and anti-angiogenic effects in the treatment of several disorders, including bone regeneration, peripheral vascular disease, diabetic retinopathy, ischemic stroke, rheumatoid arthritis, post-ischemic cardiovascular injury, age-related macular degeneration, diabetic retinopathy, gene delivery-based angiogenic therapy, protein delivery-based angiogenic therapy, stem cell angiogenic therapy, and diabetic retinopathy, cancer that may benefit from the behavior of the nanostructures in the vascular system throughout the body. In addition, the accompanying difficulties and potential future applications of NPs in treating angiogenesis-related diseases and antiangiogenic therapies are discussed.

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Section: Pro-angiogenic Factors and Anti-angiogenic Therapy For Eradi...mentioning

confidence: 99%

Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process

et al. 2022

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“…Nanomedicine is the application of nanotechnology, which is related to materials belonging to the size range of 1–100 nm, in the medical field [ 172 , 173 ]. Nanotechnology plays an extensive and important role in the diagnosis [ 174 ], detection of metastasis and treatment of cancer [ 175 ]. For example, NPs could not only outline the primary and metastatic OSCC but could show a therapeutical effect [ 176 ], and could be used as a probe for the infrared fluorescence imaging of OSCC [ 177 ].…”

Section: Nanoparticles In Mitochondria-targeted Therapy In Osccmentioning

confidence: 99%

Roles of Mitochondria in Oral Squamous Cell Carcinoma Therapy: Friend or Foe?

Bai

Wang

et al. 2022

Cancers

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Oral squamous cell carcinoma (OSCC) therapy is unsatisfactory, and the prevalence of the disease is increasing. The role of mitochondria in OSCC therapy has recently attracted increasing attention, however, many mechanisms remain unclear. Therefore, we elaborate upon relative studies in this review to achieve a better therapeutic effect of OSCC treatment in the future. Interestingly, we found that mitochondria not only contribute to OSCC therapy but also promote resistance, and targeting the mitochondria of OSCC via nanoparticles is a promising way to treat OSCC.

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“…Numerous tumor-targeting nanoparticles have been developed for use in cancer applications as a result of the growing interest in applying nanotechnology to cancer detection and treatment [ 4 , 5 ]. In order to address a synergistic strategy to combat metastatic tumors, nanomedicines are currently being used to entrap traditional therapeutics and diagnostic equipment [ 6 , 7 , 8 ]. According to the current circumstances, developing new delivery systems that are quick and simple to prepare, affordable, have high drug loading efficiency, are stable under biological conditions, encourage drug retention in tissues, and are tailored for the delivery of already-approved FDA-approved drugs is the quickest and most practical way to improve the cancer treatment regimen [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Neguț

Biţă

2023

Pharmaceutics

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Concurrent developments in anticancer nanotechnological treatments have been observed as the burden of cancer increases every year. The 21st century has seen a transformation in the study of medicine thanks to the advancement in the field of material science and nanomedicine. Improved drug delivery systems with proven efficacy and fewer side effects have been made possible. Nanoformulations with varied functions are being created using lipids, polymers, and inorganic and peptide-based nanomedicines. Therefore, thorough knowledge of these intelligent nanomedicines is crucial for developing very promising drug delivery systems. Polymeric micelles are often simple to make and have high solubilization characteristics; as a result, they seem to be a promising alternative to other nanosystems. Even though recent studies have provided an overview of polymeric micelles, here we included a discussion on the “intelligent” drug delivery from these systems. We also summarized the state-of-the-art and the most recent developments of polymeric micellar systems with respect to cancer treatments. Additionally, we gave significant attention to the clinical translation potential of polymeric micellar systems in the treatment of various cancers.

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Nanotechnology‐Based Strategies to Evaluate and Counteract Cancer Metastasis and Neoangiogenesis

Cited by 16 publications

References 266 publications

Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process

Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process

Roles of Mitochondria in Oral Squamous Cell Carcinoma Therapy: Friend or Foe?

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

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