Nanotechnology based strategies for HIV-1 and HTLV-1 retroviruses gene detection

Mozhgani, Sayed‐Hamidreza; Kermani, Hanie Ahmadzade; Norouzi, Mehdi; Arabi, Mohsen; Soltani, Saber

doi:10.1016/j.heliyon.2020.e04048

Cited by 17 publications

(14 citation statements)

References 119 publications

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“…Fluorescence-based nucleic acid assay is widely used due to its high sensitivity, diversity, and ease of operation [ 80 ]. Fluorescence occurs when a valence electron of molecule or atom is excited from its ground state and causes the emission of a photon when the excited electron returns to its original ground state [ 81 ].…”

Section: The Development Of Optical and Electrochemical Metal Nanoparticles-based Biosensors For The Detection Of Viral Rnamentioning

confidence: 99%

A Review on the Development of Gold and Silver Nanoparticles-Based Biosensor as a Detection Strategy of Emerging and Pathogenic RNA Virus

Ibrahim

Jamaluddin

Tan

et al. 2021

Sensors

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The emergence of highly pathogenic and deadly human coronaviruses, namely SARS-CoV and MERS-CoV within the past two decades and currently SARS-CoV-2, have resulted in millions of human death across the world. In addition, other human viral diseases, such as mosquito borne-viral diseases and blood-borne viruses, also contribute to a higher risk of death in severe cases. To date, there is no specific drug or medicine available to cure these human viral diseases. Therefore, the early and rapid detection without compromising the test accuracy is required in order to provide a suitable treatment for the containment of the diseases. Recently, nanomaterials-based biosensors have attracted enormous interest due to their biological activities and unique sensing properties, which enable the detection of analytes such as nucleic acid (DNA or RNA), aptamers, and proteins in clinical samples. In addition, the advances of nanotechnologies also enable the development of miniaturized detection systems for point-of-care (POC) biosensors, which could be a new strategy for detecting human viral diseases. The detection of virus-specific genes by using single-stranded DNA (ssDNA) probes has become a particular interest due to their higher sensitivity and specificity compared to immunological methods based on antibody or antigen for early diagnosis of viral infection. Hence, this review has been developed to provide an overview of the current development of nanoparticles-based biosensors that target pathogenic RNA viruses, toward a robust and effective detection strategy of the existing or newly emerging human viral diseases such as SARS-CoV-2. This review emphasizes the nanoparticles-based biosensors developed using noble metals such as gold (Au) and silver (Ag) by virtue of their powerful characteristics as a signal amplifier or enhancer in the detection of nucleic acid. In addition, this review provides a broad knowledge with respect to several analytical methods involved in the development of nanoparticles-based biosensors for the detection of viral nucleic acid using both optical and electrochemical techniques.

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Section: The Development Of Optical and Electrochemical Metal Nanoparticles-based Biosensors For The Detection Of Viral Rnamentioning

confidence: 99%

A Review on the Development of Gold and Silver Nanoparticles-Based Biosensor as a Detection Strategy of Emerging and Pathogenic RNA Virus

Ibrahim

Jamaluddin

Tan

et al. 2021

Sensors

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“…Then the tunneling current is in response to the distance from the tip to the surface, and the localized AuNPs produce a pulse current peak at the localization position. The frequency of the peak current was used to quantify the number of HIV particles according to the immune response associated with Au NPs (Mozhgani et al, 2020).…”

Section: Application Of Nanotechnology In Virus Detectionmentioning

confidence: 99%

Applications of nanotechnology in virus detection, tracking, and infection mechanisms

Kang

Tahir

Wang

et al. 2021

WIREs Nanomed Nanobiotechnol

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Viruses are among the most infectious pathogens, responsible for the highest death toll around the world. Lack of effective clinical drug for most of the viruses emphasizes the rapid and accurate diagnosis at early stages of infection to prevent rapid spread of the pathogens. Nanotechnology is an emerging field with applications in various domains, where nano‐biomedical science has many significant contributions such as effective delivery of drugs/therapeutic molecules to specific organs, imaging, sensitive detection of virus, and their accurate tracking in host cells. The nanomaterials reported for virus detection and tracking mainly include magnetic and gold NPs, ZnO/Pt‐Pd, graphene, and quantum dots (QDs). In addition, the single virus tracking technology (SVT) allowed to track the life cycle stages of an individual virus for better understanding of their dynamics within the living cells. Inorganic as well as non‐metallic fluorescent materials share the advantages of high photochemical stability, a wide range of light absorption curves and polychromatic emission. Hence, are considered as potential fluorescent nano‐probes for SVT. However, there are still some challenges: (i) clinical false positive rate of some detection methods is still high; (ii) in the virus tracking process, less adaptability of QDs owing to larger size, flicker, and possible interference with virus function; and (iii) in vivo tracking of a single virus, in real time needs further refinement. In the future, smaller, non‐toxic, and chemically stable nanomaterials are needed to improve the efficiency and accuracy of detection, and monitoring of virus infections to curb the mortalities. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease Biology‐Inspired Nanomaterials > Protein and Virus‐Based Structures

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“…They are infectious agents, mostly in nanoscale capable of causing various diseases. 82 MOFs have been used as biosensors during epidermic and pandemic outbreaks.…”

Section: Mofs As Biosensing Materials In Pandemic Outbreaksmentioning

confidence: 99%

“…The retrovirus is a RNA virus whereby its DNA is integrated into its host chromosomal DNA. 8 , 82 Detection at the early stage of infection may be difficult due to the rare proviral DNA expression in the infected host. 99 The Human Immunodeficiency Virus (HIV), which belongs to the genus Lentivirus within the family of Retroviridae and subfamily Orthoretrovirinae 99 is a human retrovirus.…”

Section: Mofs As Biosensing Materials In Pandemic Outbreaksmentioning

confidence: 99%

“…4 Examples of such routine test are the western blot and enzyme-linked immunosorbent assay (ELISA) assay. 82 Nevertheless, because of reaction of samples with one or more of the antigens, these methods suffer from some false positive and negative outcomes. 82 Researchers have taken advantage of large specific surface area, high porosity, fluorescence quenching, high loading efficiency, easy functionalization, and tunable pore properties of MOFs to deploy them in biosensing applications including the biosensing of HIV.…”

Section: Mofs As Biosensing Materials In Pandemic Outbreaksmentioning

confidence: 99%

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Metal Organic Frameworks as Biosensing Materials for COVID-19

2021

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The novel coronavirus disease (COVID-19) pandemic outbreak is the most startling public health crises with attendant global socio-economic burden ever experienced in the twenty-first century. The level of devastation by this outbreak is such that highly impacted countries will take years to recover. Studies have shown that timely detection based on accelerated sample testing and accurate diagnosis are crucial steps to reducing or preventing the spread of any pandemic outbreak. In this opinionated review, the impacts of metal organic frameworks (MOFs) as a biosensor in a pandemic outbreak is investigated with reference to COVID-19. Biosensing technologies have been proven to be very effective in clinical analyses, especially in assessment of severe infectious diseases. Polymerase chain reactions (PCR, RT-PCR, CRISPR) - based test methods predominantly used for SARS-COV-2 diagnoses have serious limitations and the health scientists and researchers are urged to come up with a more robust and versatile system for solving diagnostic problem associated with the current and future pandemic outbreaks. MOFs, an emerging crystalline material with unique characteristics will serve as promising biosensing materials in a pandemic outbreak such as the one we are in. We hereby highlight the characteristics of MOFs and their sensing applications, potentials as biosensors in a pandemic outbreak and draw the attention of researchers to a new vista of research that needs immediate action.

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Nanotechnology based strategies for HIV-1 and HTLV-1 retroviruses gene detection

Cited by 17 publications

References 119 publications

A Review on the Development of Gold and Silver Nanoparticles-Based Biosensor as a Detection Strategy of Emerging and Pathogenic RNA Virus

A Review on the Development of Gold and Silver Nanoparticles-Based Biosensor as a Detection Strategy of Emerging and Pathogenic RNA Virus

Applications of nanotechnology in virus detection, tracking, and infection mechanisms

Metal Organic Frameworks as Biosensing Materials for COVID-19

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