Nanotechnology-based drug delivery systems

Suri, Sarabjeet Singh; Fenniri, Hicham; Singh, Baljit

doi:10.1186/1745-6673-2-16

Cited by 571 publications

(262 citation statements)

References 47 publications

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“…and can be used to treat several types of parasitic infections [29][30][31][32][33]. Obviously it is very important to understand nature of biological and cellular membranes at target site, distribution and presence of drug receptors and enzymes responsible for drug metabolism.…”

Section: Introductionmentioning

confidence: 99%

Present status of nanoparticle research for treatment of Tuberculosis

2011

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-Nanotechnology has offered enormous improvement in field of therapeutics by means of designing of drug delivery systems and opened the possibility of controlling infections at the molecular level. Nanocarriers can cross biological barriers and are able to target cellular reservoirs of Mycobacterium tuberculosis (M. tuberculosis). Nanoparticle-based systems have significant potential for treatment and prevention of tuberculosis (TB). A variety of nanocarriers have been widely evaluated as potential drug delivery systems for various administration routes. Targeting the drugs to certain physiological sites such as the lymph nodes has emerged as a promising strategy in treating TB with improved drug bioavailability and reduction of the dosing frequency. Nanotechnology based rational targeting may improve therapeutic success by limiting adverse drug effects and requiring less frequent administration regimes, ultimately resulting in more patients compliance and thus attain higher adherence levels. The development of nanoparticle based aerosol vaccine is undergoing which could serve as new platform for immunization. Present article compiles the general physiological aspects of the infection along with new research uptades on nanocarriers used in prevention of tuberculosis. _______________________________________________________________________________________

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Section: Introductionmentioning

confidence: 99%

Present status of nanoparticle research for treatment of Tuberculosis

2011

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“…The high dose of puerarin, therefore, should not be a major constraint in exploring its future potential as an antifertility agent. However, NP holds tremendous potential as an efficient drug delivery system (Suri et al 2007). PN is reported to have excellent stability, enhanced intestinal absorption and increased bioavailability after oral administration (Liu et al 2009, Wu et al 2009.…”

Section: Discussionmentioning

confidence: 99%

“…There is a need to develop a new oral delivery system to overcome the limitations of puerarin and enhance its overall effectiveness. Nanoparticles (NP) hold tremendous potential as an efficient drug delivery system (Suri et al 2007). NP-mediated drug delivery may be more efficient owing to the sustained release of the drug that prolongs the contact time with the target tissue(s).…”

Section: Introductionmentioning

confidence: 99%

Molecular cues to the anti-implantation effect of nano-puerarin in rats

et al. 2016

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Puerarin, a selective oestrogen receptor modulator, intercepts implantation in rats, albeit at unacceptably higher doses. We developed poly lactic-co-glycolic acid-encapsulated nano-puerarin (PN) and mapped the molecular pathway underlying its anti-implantation effects. Smooth-surfaced and spherical PN having a mean diameter of ~147 nm was obtained with good yield, efficient encapsulation, and optimum drug loading. In culture, PN slowly and steadily released puerarin, which was readily taken up by the decidual cells. PN exerted a dose-dependent anti-implantation effect. As marked by attenuated expression of stromal cell desmin, alkaline phosphatase, IGFBP1, and decidual prolactin-related protein, the anti-implantation effect of PN seemed secondary to compromised decidualization. Using in vivo (pregnant and pseudopregnant rats) and in vitro (endometrial stromal cell culture) treatment models, we document that PN enforced inhibition of uterine expression of Hbegf and Hoxa10 and their downstream signalling molecules, Cyclin D3 (CCND3)/CDK4. PN also efficiently ablated the Ihh-Nr2f2-Bmp2 signalling pathway and invited the loss of uterine potential for decidualization. There was a dose-dependent up-regulation of RHOA and its effector protein kinase, ROCK1, leading to the promotion of MLC phosphorylation and actin-myosin interaction. PN also down-regulated the stromal cell activation of ERK½ and expression of MMP9. These effects acting together stabilized the stroma and inhibited the stromal cell migration. Central to this array of events was the adversely altered endometrial expression of oestrogen receptor subtypes and repression of progesterone receptor that indulged endless proliferation of luminal epithelia and distorted the precisely choreographed stroma-epithelia crosstalk. Thus, PN dismantles the endometrial bed preparation and prevents implantation.Reproduction (2016) 151 693-707

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“…Their surface to improve their application of NPs [17]. In order to consider the size and shape of NPs, decreasing factors, etc., have been used in the preparation of NPs [18]. The most of important dramatical feature of Zno nanoparticles is their small size and large surface area of the material that cause to increase the chemical and biological properties and the antimicrobial activities [19].…”

Section: Introductionmentioning

confidence: 99%

The Antibacterial Effects of Zno Nanoparticles on Patients with Urinary Tract Infection Isolated From Alzahra Hospital in Isfahan, Iran

Torabi

2017

Zahedan J Res Med Sci

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Background: Urinary tract infection (UTI) is a kind of disease in kidneys that often caused by Escherichia coli bacteria, especially in women. Objectives: We studied the antibacterial effects of ZnO nanoparticles On patients with urinary tract infection that isolated from Alzahra hospital in Isfahan, Iran. It is hoped that by the research community's attention to this great problem of multi drug resistance E. coli treatment by ZnO NPs. Methods: In this experimental study, urine samples of multi drug resistance E. coli bacteria, Also colloidal ZnO nanoparticles prepared in size 20 nm, spherical shape and a concentration of 200 ppm were used .The methods of research were wells and disk agar diffusion in nutriant agar & LB medium and was evaluated antibacterial properties of the nanoparticles ,then incubated for 72 hours and the diameter of inhibitory zone of growth was measured, The data were analyzed by spss 16 version software. Results: The highest resistance of E. coli to antibiotics belongs to cefazolin and cefexime. The results showed that ZnO NPs in size 20 nm and spherical shape after 72 hours at 37°C can be used to treat Urinary infections caused by E. coli, it is recommended that further research considered the effects of different infections of Urinary tract infection in In vitro condition. Conclusions: Using ZnO nanoparticles with 20 nm diameters have acceptable antibacterial effect on Escherichia coli isolated from Urinary tract infection. The current study suggests that ZnO NPs could be a good candidate for an effective antibacterial agent against E. coli.

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Nanotechnology-based drug delivery systems

Cited by 571 publications

References 47 publications

Present status of nanoparticle research for treatment of Tuberculosis

Present status of nanoparticle research for treatment of Tuberculosis

Molecular cues to the anti-implantation effect of nano-puerarin in rats

The Antibacterial Effects of Zno Nanoparticles on Patients with Urinary Tract Infection Isolated From Alzahra Hospital in Isfahan, Iran

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